A5079301007- Cardiac Imaging and Diagnostics
- Cardiovascular and exercise physiology
- Prostate Cancer Treatment and Research
- Meat and Animal Product Quality
- Coronary Interventions and Diagnostics
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Hemodynamic Monitoring and Therapy
- Obstructive Sleep Apnea Research
- Heart Failure Treatment and Management
- Hormonal and reproductive studies
- Animal Nutrition and Physiology
- Cardiac electrophysiology and arrhythmias
- Acute Myeloid Leukemia Research
- Nitric Oxide and Endothelin Effects
- Uterine Myomas and Treatments
- Infective Endocarditis Diagnosis and Management
- Acute Myocardial Infarction Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematological disorders and diagnostics
- Cardiac Valve Diseases and Treatments
- Heart Rate Variability and Autonomic Control
- Aortic Disease and Treatment Approaches
- Gout, Hyperuricemia, Uric Acid
- Aortic aneurysm repair treatments
Yokohama National University
2024
Fukui-ken Saiseikai Hospital
2013-2024
City of Hope
2006-2024
Wakayama Medical University
2012-2024
Tohoku University
2024
City Of Hope National Medical Center
2018-2024
Beijing Obstetrics and Gynecology Hospital
2019
Presbyterian Hospital
2018
NewYork–Presbyterian Hospital
2018
Cornell University
2018
SUMMARY To study the effects of glycolysis on tenderness poultry breast meat, premortem and postmortem in muscle tissue was controlled either by epinephrine administration at suitable intervals time before slaughtering or allowing birds to struggle freely just during slaughtering. Premortem glycolysis, occurring as a result death 1‐2 hr slaughtering, lowered pH meat caused toughness. Minimization more than 5 increased ultimate tenderness. The results indicate that value above 6.2 after an...
Background — Oxidative stress and inflammation are potentially involved in the pathogenesis of heart failure (HF). We examined whether antioxidant antiinflammatory treatment with probucol decreases myocardial oxidative attenuates progression left ventricular (LV) dysfunction remodeling (dilatation) tachycardia-induced HF. Methods Results studied 3 groups dogs: a sham-operated control group 2 other that underwent pacing at 240 bpm without (100 mg/kg IP per week) for 4 weeks. Dogs weeks...
Abstract Introduction Dotinurad is a newer urate-lowering agent that selectively inhibits urate transporter 1 in the renal proximal tubule and increases urinary excretion. Currently, little known about clinical efficacies of dotinurad patients with hyperuricemia hypertension. The aim this study was to assess effects selective reabsorption inhibitor on serum uric acid (SUA) levels relevant vascular markers treated Methods This investigator-initiated, multicenter, prospective, single-arm,...
Recent evidence suggests the possibility that enhanced inactivation of endothelium-derived nitric oxide (NO) by oxygen free radical (OFR) may cause endothelial dysfunction in heart failure (HF). To test this hypothesis, we examined effect antioxidant therapy on endothelium-dependent vasodilation coronary circulation a canine model tachycardia-induced HF. Endothelium-dependent was less than controls, and OFR formation arterial myocardial tissues greater HF dogs those controls. The...
This report describes our experience with reduced intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (HCT) using matched sibling and unrelated donors (MUDs) for treatment of myelofibrosis (MF). Nine patients MF (median age, 54 years) were treated RIC HCT MUDs 7 the 9 2 patients. By Lille classification, 4 characterized as having high risk, intermediate 1 low risk. The regimen consisted fludarabine a single dose total body irradiation first patient...
α 1 -Adrenergic stimulation, coupled to G q , has been shown promote heart failure. However, the role of -adrenergic signaling in regulation myocardial contractility failing myocardium is still poorly understood. To investigate this, we observed 1) effect phenylephrine on myofibrillar Ca 2+ sensitivity α-toxin-skinned cardiomyocytes, and 2) protein expression RhoA, myosin light chain phosphorylation using tachypacing-induced canine hearts. Phenylephrine significantly increased but not normal...
Abstract Background Although the prognosis of core‐binding factor ( CBF ) acute myeloid leukemia AML is better than other subtypes , 30% patients still relapse and may require allogeneic hematopoietic cell transplantation (allo HCT ). However, there no validated widely accepted scoring system to predict patient subsets with higher risk relapse. Methods Eleven centers in US Europe evaluated 247 t(8;21)(q22;q22). Results Complete remission CR rate was high (92.7%), yet occurred 27.1% patients....
Abstract Rupture of renal artery aneurysm associated with pregnancy is an uncommon condition. It known that almost all previously reported cases have occurred during pregnancy. We experienced a case rupture the early post‐partum period which was diagnosed by computed tomography and treated angiographic embolization. To our knowledge, only two been in English‐language published work. An diagnosis very challenging because clinical symptoms this condition are acute abdominal, flank or back...
Postoperative delirium in intensive care is common and associated with mortality, cognitive impairment, prolonged hospital stays high costs. We evaluate whether a nurse-led orientation program could reduce the incidence of unit after cardiovascular surgery.
Abstract BACKGROUND Hormone refractoriness is a lethal event for advanced prostate cancer patients, but the mechanisms of disease are not well elucidated, especially so‐called “outlaw” pathways androgen receptor (AR)‐dependent, androgen‐independent hormone‐refractory cancer. METHODS Androgen‐dependent LNCaP cells were treated with bicalutamide under an androgen‐depleted condition to obtain refractory cells. In obtained cell line, LNCaP‐CS10, we analyzed effects and on growth...
Saphenous vein grafts (SVGs) sometimes occur as graft stenosis or failure in coronary artery bypass grafting. The purpose of this study was to detect the factors affecting atherosclerosis. We performed two analysis. In first analysis, we enrolled 120 using conventionally harvested saphenous (C-SVG) and followed-up with multiple computed tomography angiography (CCTA). examined that contribute atherosclerosis defined by at subsequent CCTA substantial progression (a decrease ≥0.6 mm diameter)....
Recent evidence suggests that increased inactivation of endothelium-derived nitric oxide (NO) by oxygen free radical (OFR) formation is involved in the pathogenesis endothelial dysfunction heart failure (HF). However, it unclear whether OFR limits coronary flow reserve HF. To test this hypothesis, we examined effects antioxidant therapy on a canine model tachycardia-induced The (percent increase blood flow) to adenosine or 20-s ischemia was less and (electron-spin resonance spectroscopy)...
Abstract BACKGROUND Castration‐resistant prostate cancer (CRPC) is still dependent on androgen receptor (AR) signaling. We previously reported that a novel nonsteroidal AR pure antagonist, CH4933468, which thiohydantoin derivative with sulfonamide side chain, provided in vitro proof of concept but did not vivo. METHODS developed other derivatives, CH5137291, CH5138514, and CH5166623, their pharmacological properties were compared CH4933468 bicalutamide. Agonist/antagonist activities...
Resistance of prostate cancer to castration is currently an unavoidable problem. The major mechanisms underlying such resistance are androgen receptor (AR) overexpression, androgen-independent activation AR, and AR mutation. To address this problem, we developed pure antagonist, CH5137291, with nuclear translocation-inhibiting activity, compared its activity characteristics that bicalutamide. Cell lines corresponding the were used: LNCaP-BC2 having overexpression LNCaP-CS10 activation. VCaP...