A5069724614- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Gout, Hyperuricemia, Uric Acid
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Cardiac electrophysiology and arrhythmias
- Nutrition and Health in Aging
- Inflammatory Biomarkers in Disease Prognosis
- Peripheral Artery Disease Management
- Venous Thromboembolism Diagnosis and Management
- Obstructive Sleep Apnea Research
- Cardiovascular Disease and Adiposity
- Tracheal and airway disorders
- Food Allergy and Anaphylaxis Research
- Contact Dermatitis and Allergies
- Sepsis Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Cardiac Arrhythmias and Treatments
- Heart rate and cardiovascular health
- Genetics and Neurodevelopmental Disorders
Saga University
2015-2025
University of Miyazaki Hospital
2019-2023
Cardiac function declines with age, impairing exercise tolerance and negatively impacting healthy aging. Here, we observed inactivation of mitochondrial biogenesis in hearts aged mice a reduction mass. We also showed that activity the BAF chromatin remodeling complex is repressed by HINT1, whose expression heart increases leading to decreased transcription Tfam, which promotes biogenesis. Interestingly, calorie restriction (CR) not only suppressed age-related cardiac but blocked concomitant...
Frailty is characterized by reduced biological reserves and weakened resistance to stressors, common in older adults. This study evaluated the prognostic implications of frailty at hospitalization elderly patients with acute myocardial infarction (AMI) who undergo percutaneous coronary intervention (PCI).We prospectively analysed 546 AMI aged ≥80 years undergoing PCI from 2009 2017. was classified based on impairment walking (unassisted, assisted, wheelchair/non-ambulatory), cognition...
Abstract Introduction Dotinurad is a newer urate-lowering agent that selectively inhibits urate transporter 1 in the renal proximal tubule and increases urinary excretion. Currently, little known about clinical efficacies of dotinurad patients with hyperuricemia hypertension. The aim this study was to assess effects selective reabsorption inhibitor on serum uric acid (SUA) levels relevant vascular markers treated Methods This investigator-initiated, multicenter, prospective, single-arm,...
Abstract Aims Previous studies have suggested that low serum albumin (LSA) at admission for acute myocardial infarction (AMI) is associated with adverse in‐hospital outcomes. The aim of this study was to investigate whether LSA in the remote phase after AMI prognostic long‐term Methods and results This a single‐centre, retrospective consecutive patients admitted from 2008 2016. Serum concentrations were measured serially 1 year discharge Japanese patients. Occurrence composite...
Low serum albumin (LSA) on admission for acute myocardial infarction (AMI) is related to adverse in-hospital outcomes. However, the relationship between LSA and long-term post-AMI cardiovascular outcomes unknown. A single-center, non-randomized, retrospective study was performed investigate prognostic impact of at AMI death or newly developed HF in remote phase after AMI. Admission tertiles (<3.8, 3.8–4.2, ≥4.2 g/dL) were used divide 2253 consecutive from February 2008 January 2016...
Introduction We sought to investigate the prognostic impact of incident left ventricular (LV) systolic dysfunction at chronic phase acute myocardial infarction (AMI). Materials and methods Among 2,266 consecutive patients admitted for AMI, 1,330 with LV ejection fraction (LVEF) ≥ 40% during hospitalization who had LVEF data 6 months after AMI were analyzed. Patients divided into three subgroups based on months: reduced-LVEF (&lt;40%), mid-range-LVEF (≥ &lt; 50%) preserved-LVEF 50%)....
This study aimed to investigate the clinical impact of pre-procedural left atrial strain (LAS) in patients undergoing permanent pacemaker implantation (PPI).
The high post-discharge mortality rate of acute myocardial infarction (AMI) survivors is concerning, indicating a need for reliable, easy-to-use risk prediction tools. We aimed to examine if combined pre-procedural blood testing model predicts one-year in AMI survivors. Overall, 1355 consecutive patients who received primary coronary revascularization were divided into derivation (n = 949) and validation 406) cohorts. A risk-score parameters from routine on admission was generated. In the...
Background: In-hospital bleeding is associated with poor prognosis in patients acute myocardial infarction (AMI). We sought to investigate whether a combination of pre-procedural blood tests could predict the incidence in-hospital major AMI.Methods and Results: A total 1684 consecutive AMI who underwent primary percutaneous coronary intervention (PCI) were recruited randomly divided into derivation (n=1010) validation (n=674) cohorts. risk-score model was created based on parameters assessed...
Background: CREDO-Kyoto bleeding risk score was developed to predict the post-discharge events in patients with percutaneous coronary intervention. However, there were limited reports of effectiveness this in-hospital acute syndrome (ACS). Methods: We evaluated 562 consecutive ACS Saga university hospital between 2014 and 2019. Primary outcome major during hospitalization. Major defined as GUSTO moderate/severe bleeding. Patients classified into three groups according (low, intermediate...
Aims: To determine the prognostic impact of left ventricular ejection fraction (LVEF) trajectories from acute to chronic phase myocardial infarction (AMI). Materials and methods: Among 2,266 consecutive patients admitted for AMI February 2008 January 2016, 1,330 survivors with LV ≥40% during hospitalization who had LVEF data at 6 months after were analyzed. Patients divided into three subgroups based on months: reduced-LVEF (<40%), mildly-reduced-LVEF (≥40% <50%) preserved-LVEF (≥50%)....