A5083049128- Lipoproteins and Cardiovascular Health
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Cardiac pacing and defibrillation studies
- Coronary Interventions and Diagnostics
- Pharmaceutical Economics and Policy
- Cardiac electrophysiology and arrhythmias
- Health Systems, Economic Evaluations, Quality of Life
- Venous Thromboembolism Diagnosis and Management
- Diabetes Treatment and Management
- Biotechnology and Related Fields
- Computational Drug Discovery Methods
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Inflammatory Biomarkers in Disease Prognosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Telomeres, Telomerase, and Senescence
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Cardiovascular and exercise physiology
- Infrared Thermography in Medicine
Kobe Medical Center
2023
National Hospital Organization
2023
Saga University
2015-2021
Imperial College London
2018-2021
Saga-Ken Medical Centre Koseikan
2021
Edogawa Hospital
2009-2013
Sustained reductions in low-density lipoprotein cholesterol (LDL-C) with lipid-lowering therapies that require frequent dosing are reliant on patient adherence, and poor adherence is associated worse clinical outcomes.To determine whether inclisiran, a small interfering RNA, reduces mean LDL-C exposure an infrequent regimen.Prespecified analysis of randomized, double-blind, placebo-controlled multicenter phase 2 trial. Participants were followed up monthly for levels proprotein convertase...
An excessive inflammatory response after myocardial infarction (MI) increases injury. The toll-like receptor (TLR)-4 is activated by the recognition of endogenous ligands and proinflammatory when there tissue apoptosis inhibitor macrophage (AIM) known to provoke an efflux saturated free fatty acids (FFA) due lipolysis, which causes inflammation via TLR-4 pathway. Therefore, this study investigated hypothesis that AIM a MI.The left anterior descending coronary artery was ligated induce MI in...
Abstract Background Glucagon-like peptide-1 (GLP-1) reduces cardiovascular events in diabetic patients; however, its counter-protective effects have also been suggested patients with heart failure and the clear explanation for mechanisms not yet offered. Methods The of GLP-1 analog on cardiac function energy metabolism, especially glycemic lipid metabolisms were elucidated using non-diabetic J2N-k hamsters which showed spontaneous dilated cardiomyopathy. treated PBS (HF group), low-dose...
Recently, calcium channel blockers (CCBs) have been reported to reduce atherosclerosis with anti-inflammatory or antiatherosclerotic effects in vivo. It is well established that monocytes and macrophages play important roles promoting atherosclerosis. However, the of CCBs on macrophage activation remain unclear. The aim this study was evaluate azelnidipine, a dihydropyridine L-type CCB, clarify mechanisms atherosclerosis.THP-1 monocytes, human leukemic cell line, were stimulated 50 ng/mL...
Abstract 2-Cl-C.OXT-A (COA-Cl) is a novel nucleic acid analogue that promotes tube-forming activity of human umbilical vein endothelial cells (HUVEC) through vascular growth factor (VEGF). The development coronary collateral circulation critical to rescue the ischemic myocardium and prevent subsequent irreversible injury. We evaluated whether COA-Cl can promote angiogenesis in tissue, reduce infarct size preserve cardiac contractility vivo . Mice received or placebo daily for three days...
Background: In-hospital bleeding is associated with poor prognosis in patients acute myocardial infarction (AMI). We sought to investigate whether a combination of pre-procedural blood tests could predict the incidence in-hospital major AMI.Methods and Results: A total 1684 consecutive AMI who underwent primary percutaneous coronary intervention (PCI) were recruited randomly divided into derivation (n=1010) validation (n=674) cohorts. risk-score model was created based on parameters assessed...
Objective: The diabetes mellitus is one of high risk factors for the acute coronary syndrome. dipeptidyl-peptidase 4(DPP-4) inhibitors antihyperglycemic agents with possible protective effects cardiovascular system. It was reported that Glucagon-like peptide-1 had improved left ventricular systolic function, and DPP-4 attenuated post-infarct myocardial remodeling. In contrast, rate hospitalization heart failure increased by saxagliptin in SAVOR-TIMI 53 trial. purpose this study evaluating on...
Objective: The persistent inflammation response after myocardial infarction increases injury, and causes heart failure due to cardiac dysfunction remodeling. Toll-like receptors (TLR)-4 was activated by the recognition of not only pathogen-associated molecular patterns but also endogenous ligands it serves as proinflammatory function in circumstances involving tissue injury. Whereas, reported apoptosis inhibitor macrophage (AIM) provoke an efflux saturated free fatty acid (FFA), one TLR4...