A5051437482- Heart Rate Variability and Autonomic Control
- Non-Invasive Vital Sign Monitoring
- Mitochondrial Function and Pathology
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Fibrosis and Remodeling
- Helicobacter pylori-related gastroenterology studies
- Cardiac electrophysiology and arrhythmias
- Pancreatitis Pathology and Treatment
- Cardiovascular Health and Disease Prevention
- Respiratory Support and Mechanisms
- Cardiac Ischemia and Reperfusion
- Obstructive Sleep Apnea Research
- Cardiac Imaging and Diagnostics
- Liver Disease Diagnosis and Treatment
- Neural Networks and Applications
- Mechanical Circulatory Support Devices
- Pancreatic function and diabetes
- Atrial Fibrillation Management and Outcomes
- Gastrointestinal disorders and treatments
- Pharmacogenetics and Drug Metabolism
- ATP Synthase and ATPases Research
- Cardiac Arrest and Resuscitation
- Erythrocyte Function and Pathophysiology
- Organ Donation and Transplantation
- Coronary Interventions and Diagnostics
Iwate Medical University
2025
University of Ottawa
2019-2023
Institute of Electrical and Electronics Engineers
2021
University of Catania
2021
Kracie (Japan)
2018
Kyushu University
1990-2017
Saiseikai Kumamoto Hospital
2014-2017
Fukui-ken Saiseikai Hospital
2010-2013
Kyushu University Hospital
2013
YKK (Japan)
2011
Mitochondrial DNA (mtDNA) is highly susceptible to injury induced by reactive oxygen species (ROS). During aging, mutations of mtDNA accumulate induce dysfunction the respiratory chain, resulting in enhanced ROS production. Therefore, age-dependent memory impairment may result from oxidative stress derived chain. transcription factor A (TFAM) now known have roles not only replication but also its maintenance. We herein report that an overexpression TFAM HeLa cells significantly inhibited...
To determine whether the corneal arcus affects sealing of clear incision (CCI) in cataract surgery. This study was a retrospective cohort study. The patients were divided into two groups based on stromal hydration required to close CCI. classified according its degree as none, partial (if < 180 degrees), and circumferential ≥ degrees). Multiple logistic regression conducted identify independent variables such age at surgery, sex, laterality, surgical time, associated with CCI sealing. Among...
It has been shown that renal responses to atrial natriuretic peptide (ANP) are markedly attenuated in patients with heart failure. This study aimed determine if vasodilative response ANP is altered In failure (n = 7) and age-matched normal subjects 7), forearm blood flow was measured using a strain-gauge plethysmograph during intra-arterial infusion of alpha-human (50, 100, 200, 400 ng/min) or nitroglycerin (100, 400, 600 ng/min). Forearm vasodilatation evoked considerably less (p than 0.01)...
Fas ligand (FasL), either in the membrane bound form or soluble form, has cytotoxic activity against Fas‐expressing cells. We report a case of nasal lymphoma accompanied by liver damage and pancytopenia. The serum level FasL (sFasL) was very high on admission, but rapidly decreased to normal levels after chemotherapy for lymphoma. Liver pancytopenia also improved with decrease sFasL. Since is expressed both hepatocytes haemopoietic cells, these facts suggest that cells directly associated...
Plasma concentrations of free fatty acids are increased in metabolic syndrome, and the may cause cellular damage via induction oxidative stress. The present study was designed to determine whether increase can modify sulfhydryl group position 34 albumin (Cys34) enhance redox‐cycling activity copper–albumin complex high‐fat diet‐induced obese mice. mice were fed with commercial normal diet or water ad libitum for 3 months. diet‐fed developed obesity, hyperlipemia, hyperglycemia. plasma...
Phospholipase A2 (PLA2) has been suggested to play an important role in the pathogenesis of acute pancreatitis, part through PLA2-generated phospholipid by-products, most notably lysophosphatidylcholine (lyso-PC). The effects lyso-PC on pancreatic acinar cells, other than induction necrosis, are poorly characterized. Here we examined apoptosis rat AR42J cells. Lyso-PC induced a dose-dependent manner at 10 and 25 μM, but cell lysis ≥50 μM. Lyso-PC–induced (at μM) was not blocked by protein...
Mucosa-associated lymphoid tissue (MALT) lymphomas are localized primarily in the gastrointestinal tract and characterized by an indolent nature favorable outcome with specific therapy. Gastric MALT closely linked to Helicobacter pylori (H. pylori) infection, for which eradication therapy is recognized as effective primary treatment disease. However, there little information about long-term outcomes after In present study, we elucidated of 74 patients (70 H. pylori-positive 4 negative cases)...
Introduction Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-activated transcription factor that controls growth, differentiation, and inflammation in different tissues. Roles of PPAR-γ activation pancreatic acinar cells are poorly characterized. Aims To examine the effects on induction apoptosis rat AR42J cells. Methodology were treated with ligands PPAR-γ, was evaluated by cell viability, DNA-fragmentation, flow cytometry. Results Treatment (15-deoxy-▵12,14-prostaglandin...
Reactive oxygen species (ROS) is increased in myocardium after myocardial infarction (MI), which may play a causal role cardiac remodelling. However, there scant direct and longitudinal evidence that systemic oxidative stress enhanced accompanying an increase of ROS myocardium. The authors conducted comprehensive investigation markers by simultaneously sampling urine, blood vivo ESR for the heart at different stages post-MI remodelling mouse with permanent occlusion left coronary artery....
Background In detecting coronary artery disease (CAD), fusion images obtained by combining myocardial perfusion imaging (MPI) and computed tomography angiography (CTCA) have shown a higher accuracy clinical usefulness than these modalities used separately or simple comparison of individual images. However, the use has been restricted necessity obtaining with an integral type device devices made same manufacturer. Thus, we evaluated detection hemodynamically significant CAD created newly...
Helicobacter pylori adheres to gastric epithelial cells and stimulates interleukin-8 production. Ceramide, a lipid second messenger, has become known as an important mediator of some actions several cytokines. We have recently reported that H. pylori-dependent ceramide production may activate nuclear factor-kappaB mediate expression in human cancer cell lines. In this study, we evaluated the effect rebamipide, antigastritis antiulcer agent, on subsequent Kato III cells. Rebamipide inhibited...
Initiating and weaning procedure of noninvasive positive pressure ventilation (NIPPV) on acute cardiogenic pulmonary edema (ACPE) has been determined empirically, the total time its use sometimes prolonged unnecessarily. A simple protocol for may facilitate initiation avoids prolongation NIPPV treatment. We designed a step-wise retrospectively examined clinical outcome our in 45 patients with ACPE. Almost all recovered from respiratory distress successfully. There was no intubation nor...
Changes in the biomechanical functions of artery serve as important indicators for prediction cardiovascular disease. One challenges ultrasonic arterial measurement is compression due to weight a conventional ultrasound probe employed and/or undesired motion, resulting artifacts on results. An approach address this issue with low-cost consideration use flexible, lightweight wearable sensor which could reduce or avoid deformation interest beneath during measurement. A flexible was constructed...
We report a case of large intra-aortic thrombosis in an 83-year-old woman concurrent with metastatic mediastinal leiomyosarcoma. Imaging studies incidentally detected malignant tumour metastasising to bilateral adrenals and extensive mass that was suspected be thrombosis. One month later massive embolism developed the lower limb her condition deteriorated rapidly resulting death. Autopsy revealed diffused proliferation highly pleomorphic atypical cells accompanied by necrosis mediastinum...
Central baroreflex failure in patients with spinal cord injury results serious orthostatic hypotension. We examined if transcutaneous electrical stimulation regulates arterial pressure those patients. identified skin regions capable of increasing and determined respective transfer function. Using the function, we designed feedback regulator (i.e., bionic system) to control pressure. Orthostatic stress decreased profoundly. Activation restored maintained at pre-specified levels. conclude that...