A5020156881- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Cardiac Arrest and Resuscitation
- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Fibrosis and Remodeling
- Cardiac Structural Anomalies and Repair
- Cardiomyopathy and Myosin Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Lipoproteins and Cardiovascular Health
- Cardiac electrophysiology and arrhythmias
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peptidase Inhibition and Analysis
- Heart Rate Variability and Autonomic Control
- Cardiac Health and Mental Health
- Mitochondrial Function and Pathology
- Potassium and Related Disorders
- Heart rate and cardiovascular health
- Traumatic Brain Injury and Neurovascular Disturbances
- Takotsubo Cardiomyopathy and Associated Phenomena
- Public Administration and Political Analysis
- Immune Cell Function and Interaction
- Diabetes Treatment and Management
- Metabolism and Genetic Disorders
Kyushu University
2019-2025
Massachusetts General Hospital
2024
Broad Institute
2024
RIKEN Center for Integrative Medical Sciences
2024
Teikyo University Chiba Medical Center
2024
Japanese Circulation Society
2023
Society for Vascular Surgery
2023
Amyloidosis Foundation
2021
Research Network (United States)
2021
Aso Iizuka Hospital
2015-2017
Ischemia-reperfusion (I/R) injury is a promising therapeutic target to improve clinical outcomes after acute myocardial infarction. Ferroptosis, triggered by iron overload and excessive lipid peroxides, reportedly involved in I/R injury. However, its significance mechanistic basis remain unclear. Here, we show that glutathione peroxidase 4 (GPx4), key endogenous suppressor of ferroptosis, determines the susceptibility Importantly, ferroptosis major mode cell death injury, distinct from...
Mitochondrial DNA (mtDNA)-induced myocardial inflammation is intimately involved in cardiac remodeling. ZBP1 (Z-DNA binding protein 1) a pattern recognition receptor positively regulating response to mtDNA inflammatory cells, fibroblasts, and endothelial cells. However, the role of remodeling remains unclear. The aim this study was elucidate mtDNA-induced cardiomyocytes failing hearts.mtDNA administrated into isolated cardiomyocytes. Myocardial infarctionwas conducted wild type knockout...
Background:With aging population, the prevalence and incidence of heart failure (HF) have been increasing worldwide. However, characteristics outcomes patients with HF in an era are not well established Japan.
Dipeptidyl peptidase-4 (DPP-4) inhibitors have been shown to exert pleiotropic effects on heart failure (HF) in animal experiments.This study sought investigate the impact of DPP-4 HF patients with diabetes mellitus (DM).We analyzed hospitalized and DM enrolled JROADHF (Japanese Registry Of Acute Decompensated Heart Failure) registry, a nationwide registry acute decompensated HF. Primary exposure was use inhibitor. The primary outcome composite cardiovascular death or hospitalization during...
Abstract Aims Individual risk stratification is a fundamental strategy in managing patients with heart failure (HF). Artificial intelligence, particularly machine learning (ML), can develop superior models for predicting the prognosis of HF patients, and administrative claim data (ACD) are suitable ML analysis because ACD structured database. The objective this study was to analyse using an algorithm, predict 1 year mortality HF, finally easy‐to‐use prediction model high accuracy top...
Advances in catheter ablation (CA) for atrial fibrillation (AF) have improved the prognosis of patients with heart failure (HF) and AF. However, its optimal timing remains to be fully elucidated.The aim this study was investigate prognostic impact early CA HF AF hospitalized worsening HF.From JROADHF (Japanese Registry Acute Decompensated Heart Failure) (n = 13,238), who underwent within 90 days after admission (early CA; n 103) those did not (control; 2,683) were identified. Mortality...
Abstract Aims Atrial fibrillation (AF) type (paroxysmal, persistent, or permanent) is important in determining therapeutic management; however, clinical outcomes by AF are largely unknown for hospitalized patients with heart failure (HF). Methods and results The Japanese Registry Of Acute Decompensated Heart Failure a retrospective, multicenter, nationwide registry of acute HF Japan. Follow-up data were collected up to 5 years after hospitalization. Patients divided based on diagnosis into 3...
Moderate/severe anemia [hemoglobin (Hb) < 10 g/dL] is recommended to be treated in patients with renal anemia. However, the optimal therapeutic target for Hb levels heart failure (HF) unknown. This study aimed investigate impact of severity anemia, especially moderate/severe associated dysfunction (RD: eGFR 60 mL/min/1.73 m2) HF patients. We analyzed 1,608 from Japanese Cardiac Registry Heart Failure Cardiology (JCARE-CARD) database. Patients were classified based on admission...
Abstract Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) and nuclear factor-kappa B (NF-κB) play crucial roles in pathogenesis of doxorubicin (DOX)-induced cardiomyopathy. Their activities are regulated by intracellular . We hypothesized that blockade L-type channel (LTCC) could attenuate DOX-induced cardiomyopathy regulating CaMKII NF-κB. DOX activated NF-κB through their phosphorylation increased cleaved caspase 3 cardiomyocytes. Pharmacological or gene knockdown LTCC nifedipine...
Nox4 (NADPH [Nicotinamide adenine dinucleotide phosphate] oxidase 4) is a major source of oxidative stress and intimately involved in cardiac hypertrophy. DPP (Dipeptidyl peptidase)-4 inhibitor has been reported to regulate expression adipose tissues. However, its effects on hypertrophy are still unclear. We investigated whether DPP-4 could ameliorate by regulating downstream targets. Ang II (Angiotensin II; 1.44 mg/kg per day) or saline was continuously infused into C57BL/6J mice with...
Abstract Heart failure (HF) occurs frequently among older individuals, and dysfunction of cardiac mitochondria is often observed. We here show the cardiac-specific downregulation a certain mitochondrial component during chronological aging mice, which detrimental to heart. MitoNEET outer membrane protein, encoded by CDGSH iron sulfur domain 1 (CISD1). Expression mitoNEET was specifically downregulated in heart kidney chronologically aged mice. Mice with constitutive deletion CISD1 on...
Abstract Aims Despite advances in therapies, the disease burden of heart failure (HF) has been rising globally. International comparisons HF management and outcomes may reveal care patterns that improve outcomes. Accordingly, we examined clinical patient older adults hospitalized for acute United States (US) Japan. Methods We identified patients aged >65 who were 2013 using US Medicare data Japanese Registry Acute Decompensated Heart Failure (JROADHF). described characteristics,...
Background Withdrawal of optimal medical therapy has been reported to relapse cardiac dysfunction in patients with dilated cardiomyopathy (DCM) whose function had improved. However, it is unknown whether beta‐blockers can prevent deterioration those patients. We examined the effect on left ventricular ejection fraction (LVEF) recovered DCM. Methods and Results analyzed clinical personal record DCM, a national database Japanese Ministry Health, Labor Welfare, between 2003 2014. Recovered DCM...
Background Although a tool for sharing patient prognosis among all medical staff is desirable in heart failure (HF) cases, only few simple HF prognostic scores are available. We previously presented the A 2 B score, user‐friendly risk and validated it small single‐center cohort. In present study, we larger nationwide Methods Results examined 2‐year mortality relation to 3483 patients from Japanese cohort attempted stratify their prognoses according scores. The score was determined by...
Spironolactone has been shown to improve outcomes in patients with heart failure (HF) reduced ejection fraction (EF). We investigated whether the discharge use of spironolactone could be associated better long-term among HF mid-range EF (HFmrEF).
Molecular mechanisms mediating cardiac hypertrophy by glucose metabolism are incompletely understood. Hexosamine biosynthesis pathway (HBP), an accessory of glycolysis, is known to be involved in the attachment O-linked N-acetylglucosamine motif (O-GlcNAcylation) proteins, a post-translational modification. We here demonstrate that glutamine-fructose-6-phosphate amidotransferase 2 (GFAT2), critical HBP enzyme, major isoform GFAT heart and increased response several hypertrophic stimuli,...
Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) have been shown to prevent left ventricular remodeling improve outcomes of patients with heart failure (HF). This study aimed investigate whether the use ACEi/ARB could be associated HF recovered ejection fraction (HFrecEF) in dilated cardiomyopathy (DCM).
Background: The impact of early implementation cardiac rehabilitation (CR) in heart failure (HF) patients remains to be elucidated. This study sought determine whether CR during HF hospitalization could improve prognostic outcomes with acute decompensated HF. Methods: We analyzed enrolled the JROADHF (Japanese Registry Acute Decompensated Heart Failure) registry, a retrospective, multicenter, nationwide registry hospitalized for Eligible were divided into 2 groups according hospitalization....
The present study aimed to clarify the regional variations in clinical practice and prognosis of patients with heart failure reduced ejection fraction (HFrEF) Japan using Japanese Registry Acute Decompensated Heart Failure (JROADHF).
Doxorubicin (DOX)-induced cardiomyopathy has poor prognosis, and myocardial inflammation is intimately involved in its pathophysiology. The role of invariant natural killer T (iNKT) cells not been fully determined this disease. We here demonstrated that activation iNKT by α-galactosylceramide (GC) attenuated DOX-induced cardiomyocyte death cardiac dysfunction. αGC increased interferon (IFN)-γ phosphorylation signal transducers activators transcription 1 (STAT1) extracellular signal-regulated...
Angiotensin-converting enzyme inhibitors (ACEis) or angiotensin II receptor blockers (ARBs) have been shown to be associated with recovery of cardiac function in patients dilated cardiomyopathy (DCM). The aim this study was assess comparative effectiveness ACEis vs. ARBs on left ventricular ejection fraction (LVEF) among DCM.We analysed the clinical personal records DCM, a national database Japanese Ministry Health, Labour and Welfare, from 2003 2014. Patients LVEF < 40% either were...
The delayed administration of epinephrine has been proven to worsen the neurological outcomes patients with out-of-hospital cardiac arrest (OHCA) and shockable rhythm or asystole. We aimed investigate whether might also witnessed OHCA initial pulseless electrical activity (PEA).The JAAM-OHCA Registry is a multicentre registry including between 2014 2017. Patients emergency medical services (EMS)-treated PEA were included. primary exposure was time from EMS call epinephrine. secondary...