A5005970957- Atrial Fibrillation Management and Outcomes
- Cardiac Fibrosis and Remodeling
- Cardiac Arrhythmias and Treatments
- Heart Failure Treatment and Management
- Potassium and Related Disorders
- Diabetes Treatment and Management
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac pacing and defibrillation studies
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Immune Cell Function and Interaction
- Takotsubo Cardiomyopathy and Associated Phenomena
- Glycosylation and Glycoproteins Research
- Mitochondrial Function and Pathology
- Organ Transplantation Techniques and Outcomes
- Neuroblastoma Research and Treatments
- Cardiovascular Function and Risk Factors
- Cancer, Hypoxia, and Metabolism
- NF-κB Signaling Pathways
- Signaling Pathways in Disease
- Lymphatic Disorders and Treatments
- Pericarditis and Cardiac Tamponade
- Infective Endocarditis Diagnosis and Management
- Cardiac Ischemia and Reperfusion
- Balance, Gait, and Falls Prevention
Japanese Red Cross Fukuoka Hospital
2023-2024
Kyushu University
2017-2023
Matsuyama Red Cross Hospital
2016-2017
Morishita Jintan (Japan)
2011
Augsburg University
2011
Ischemia-reperfusion (I/R) injury is a promising therapeutic target to improve clinical outcomes after acute myocardial infarction. Ferroptosis, triggered by iron overload and excessive lipid peroxides, reportedly involved in I/R injury. However, its significance mechanistic basis remain unclear. Here, we show that glutathione peroxidase 4 (GPx4), key endogenous suppressor of ferroptosis, determines the susceptibility Importantly, ferroptosis major mode cell death injury, distinct from...
Mitochondrial DNA (mtDNA)-induced myocardial inflammation is intimately involved in cardiac remodeling. ZBP1 (Z-DNA binding protein 1) a pattern recognition receptor positively regulating response to mtDNA inflammatory cells, fibroblasts, and endothelial cells. However, the role of remodeling remains unclear. The aim this study was elucidate mtDNA-induced cardiomyocytes failing hearts.mtDNA administrated into isolated cardiomyocytes. Myocardial infarctionwas conducted wild type knockout...
Abstract Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) and nuclear factor-kappa B (NF-κB) play crucial roles in pathogenesis of doxorubicin (DOX)-induced cardiomyopathy. Their activities are regulated by intracellular . We hypothesized that blockade L-type channel (LTCC) could attenuate DOX-induced cardiomyopathy regulating CaMKII NF-κB. DOX activated NF-κB through their phosphorylation increased cleaved caspase 3 cardiomyocytes. Pharmacological or gene knockdown LTCC nifedipine...
Nox4 (NADPH [Nicotinamide adenine dinucleotide phosphate] oxidase 4) is a major source of oxidative stress and intimately involved in cardiac hypertrophy. DPP (Dipeptidyl peptidase)-4 inhibitor has been reported to regulate expression adipose tissues. However, its effects on hypertrophy are still unclear. We investigated whether DPP-4 could ameliorate by regulating downstream targets. Ang II (Angiotensin II; 1.44 mg/kg per day) or saline was continuously infused into C57BL/6J mice with...
We previously demonstrated that higher simple guideline-directed medical therapy (GDMT) scores (comprising renin-angiotensin system inhibitors, β-blockers, mineralocorticoid antagonists, and sodium-glucose cotransporter 2 inhibitors) at discharge were correlated with improved prognosis in heart failure (HF) patients. HF readmissions are linked to adverse outcomes, emphasizing the need for enhanced optimization of GDMT.
The guideline-directed medical therapy (GDMT) has been recommended for heart failure (HF) with reduced ejection fraction (HFrEF) based on the accumulating clinical evidence. However, it is difficult to implement all trial-proven medications every patient in real world.A simple GDMT score was created, according combination of drugs (renin-angiotensin system inhibitors, beta-blockers, mineralocorticoid receptor antagonists, and sodium-glucose transporter 2 inhibitors) administration their...
Molecular mechanisms mediating cardiac hypertrophy by glucose metabolism are incompletely understood. Hexosamine biosynthesis pathway (HBP), an accessory of glycolysis, is known to be involved in the attachment O-linked N-acetylglucosamine motif (O-GlcNAcylation) proteins, a post-translational modification. We here demonstrate that glutamine-fructose-6-phosphate amidotransferase 2 (GFAT2), critical HBP enzyme, major isoform GFAT heart and increased response several hypertrophic stimuli,...
Dilated cardiomyopathy (DCM) is a life-threatening disease, resulting in refractory heart failure. An immune disorder underlies the pathophysiology associated with failure progression. Invariant natural killer T (iNKT) cell activation prospective therapeutic strategy for ischemic disease. However, its efficacy nonischemic cardiomyopathy, such as DCM, remains to be elucidated, and feasible modality iNKT humans yet validated.Dendritic cells isolated from human volunteers were pulsed...
Doxorubicin (DOX)-induced cardiomyopathy has poor prognosis, and myocardial inflammation is intimately involved in its pathophysiology. The role of invariant natural killer T (iNKT) cells not been fully determined this disease. We here demonstrated that activation iNKT by α-galactosylceramide (GC) attenuated DOX-induced cardiomyocyte death cardiac dysfunction. αGC increased interferon (IFN)-γ phosphorylation signal transducers activators transcription 1 (STAT1) extracellular signal-regulated...
Background: The efficacy of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in patients with acute chronic heart failure (HF) is increasingly being reported. However, it not clear when SGLT2i should be initiated decompensated HF (ADHF) after hospitalization. We retrospectively analyzed ADHF newly prescribed SGLT2i. Methods and Results: Among the 694 hospitalized due to between May 2019 2022, data were extracted for 168 during index These divided into groups: early group (92 who started...
Key Clinical Message We describe the case that persistent atrial fibrillation refractory to rhythm control by pharmacotherapy and electrical cardioversions caused tachycardia‐induced cardiomyopathy with low ejection fraction hemodynamic instability. Mechanical support using an intra‐aortic balloon pump is one of choices during catheter ablation pulmonary vein isolation.
Abstract Background The aim of this study was to compare the short-term outcomes duodenum-first multidirectional approach (DMA) in laparoscopic right colectomy with those conventional medial assess its safety and feasibility. Methods This retrospective enrolled 120 patients who had surgery for right-sided colon cancer our institution between April 2013 December 2019. Fifty-four underwent using approach; among these, 20 DMA 34 caudal-first (CMA). Sixty-six approach. Complications within 30...
Abstract Background Transforming growth factor beta (TGF-β) critically mediates cardiac fibrosis by transforming fibroblasts to myofibroblasts in pathological conditions. Cyclin dependent kinases (CDKs), cell cycle-regulating proteins, are known be intimately involved fibrosis. Among CDK isoforms, CDK1 is essential for cycle progression and division. It reported some interphase CDKs such as CDK4 or CDK6 were fibrosis, however, detailed mechanisms of through its interactions with TGF-β...
Abstract We previously reported that sinus restoration either with drugs or DC cardioversion prior to catheter ablation (CA) was associated a better outcome in persistent atrial fibrillation (AF). As an antiarrhythmic agent for AF, amiodarone is recommended patients structural heart disease. Bepridil, unique multichannel inhibitor, has comparable defibrillation efficacy and fewer extracardiac complications than amiodarone, although safety of bepridil not been established those left...
Backgrounds: Heart Failure (HF) is a risk factor for new-onset atrial fibrillation (AF), and the AF associated with worse prognosis in HF patients. It has been reported that renin-angiotensin system inhibitor (RASi), β-blocker, mineral-corticoid receptor antagonist (MRA) Sodium-glucose cotransporter 2 inhibitors (SGLT2i) prevent However, significance of contemporary guideline-directed medical therapy (GDMT) (RASi/ARNI + β-blocker MRA SGLT2i) on unknown. We investigated impact GDMT AF....
Abstract Background Mitochondrial dysfunction has been highlighted as a critical driver of cardiac remodeling and failure. Mitochondria contains about 1500 proteins, 99% which are encoded in the nuclear genome. Therefore, protein import into mitochondria is essential to maintain mitochondrial function. Previous reports suggest that nuclear-encoded precursor proteins by multiple complex; translocase outer membrane (TOM), inner (TIM), associated motor (PAM). However, role these machineries...
症例はアルコール肝硬変を既往にもつ64歳の男性で，右下腹部痛と血便のため前医を受診され，CTで終末回腸に壁肥厚を指摘され当院紹介となった．カプセル内視鏡で，中部から下部小腸を中心に頂部発赤調のSMT様隆起の多発を認め，ダブルバルーン内視鏡を用いて病変より生検を行い，回腸に多発する神経内分泌腫瘍（Neuroendocrine tumor；以下，NETと略記）の診断となり手術目的に当科を紹介受診された．術中所見ではTreitz靭帯より315cmから365cmに多発する腫瘍を認め，同部は小腸切除を施行した．また，術中内視鏡で同部以外の離れた6ヵ所にも腫瘍を認め，小腸切除後の栄養障害および肝機能増悪を回避するため，それぞれ楔状に局所切除を施行した．術後の病理診断で腫瘍はすべてNET（G1，G2）の診断であった．多発する小腸NETは本邦では比較的稀な疾患であるため，若干の考察を加えて報告する．
Abstract Background Number of hemodialysis (HD) patients, especially those with diabetic nephropathy (DN) has increased all over the world. It is well known that leading cause death in HD patients cardiovascular event, however, little regarding long-term clinical outcomes acute coronary syndrome (ACS) undergoing primary percutaneous intervention (pPCI) current real-world setting. Purpose We aimed to characterize and clarify outcome ACS pPCI. Method: Consecutive 531 (70.3±13.0 yrs, male...
Abstract Background Heart failure (HF) coexists with both atrial fibrillation (AF) and chronic kidney disease (CKD) exacerbate each other. All of them are increasing in the aging society all over world. Little is known regarding impact cardiorenal syndrome (CRS) on clinical outcomes patients AF undergoing catheter ablation (AFCA) real-world setting. Purpose In present study, we investigated CRS de novo AFCA. Method: Consecutive 494 (68.1±11.1 yrs, male 68.0%) our hospital from April 2019 to...
Abstract Background Therapeutic strategy for non-pulmonary vein (PV) trigger of atrial fibrillation (AF) has not been well established although they are the major cause AF recurrence after PV isolation. The postero-septum or right crista terminalis (CT) common non-PV sites AF. For them, a focal ablation is often insufficient due to regional arrhythmogenicity. We devised an original linear method, named "Icho Line". Icho means ginkgo in Japanese. Methods Eight hundred and thirty-two patients...
Abstract Backgrounds Guideline-directed medical therapy (GDMT) has been recommended for heart failure (HF) with reduced EF (HFrEF) based on the accumulating clinical evidence. However, it is difficult to introduce all trial-proven drugs every patient in a real-world setting. Purpose We developed simple GDMT score consisting of RAS (renin-angiotensin system) inhibitor, beta-blocker, MRA (mineralocorticoid receptor antagonist), and SGLT2 (sodium-glucose cotransporter 2) which modification...