A5068232637- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Nitric Oxide and Endothelin Effects
- Potassium and Related Disorders
- Stress Responses and Cortisol
- Pharmaceutical Practices and Patient Outcomes
- Hormonal Regulation and Hypertension
- Heart Rate Variability and Autonomic Control
- Electrolyte and hormonal disorders
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Cardiac Fibrosis and Remodeling
- Diabetes Treatment and Management
- Medication Adherence and Compliance
- Coronary Interventions and Diagnostics
- Neuroscience of respiration and sleep
- Cardiac Imaging and Diagnostics
- Neuropeptides and Animal Physiology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Fatty Acid Research and Health
- Health Systems, Economic Evaluations, Quality of Life
- Antiplatelet Therapy and Cardiovascular Diseases
- Radiation Dose and Imaging
Japanese Red Cross Fukuoka Hospital
2016-2024
British Heart Foundation
2022
University of Leeds
2022
Red Cross Hospital
2022
Krankenhaus vom Roten Kreuz
2022
Saiseikai Fukuoka General Hospital
2013-2021
Koga Hospital
2014
St Mary's Hospital
2014
Japan Community Healthcare Organization
2014
Kyushu Hospital
2014
The rostral ventrolateral medulla (RVLM) of the brainstem and paraventricular nucleus (PVN) hypothalamus play crucial roles in central cardiovascular regulation. In hypertensive rats, an imbalance excitatory inhibitory inputs to RVLM enhances sympathetic outflow. Increased reactive oxygen species (ROS) also contribute sympathoexcitation, leading hypertension. aim present study was elucidate whether ROS modulate synaptic transmission via amino acids influence from PVN spontaneously rats...
Abstract Aims The aim of this study was to compare the diagnostic performance nutritional indicators, mini assessment‐short form (MNA‐SF), geriatric risk index (GNRI), and controlling status (CONUT), in heart failure (HF) patients. Methods results Nutritional prospectively assessed by aforementioned three indicators 150 outpatients with HF who were then followed for 1 year. prevalence patients as MNA‐SF, GNRI, CONUT scores 50.0%, 13.3%, 54.0%, respectively. There slight agreement assessment...
To clarify the role of squalene peroxide in occurrence skin damage from sunburn, optimum condition peroxidation and effect on cutaneous tissue were examined. Peroxidation was more easily induced than palmitoleic acid oleic unsaturated lipid occurred sebum. The gradually by U.V. irradation, it is parallel to increases malonyldialdehyde production (production lipoperoxide). This carries out case high temperature (40 degrees C 30 C), low pH. Good correspondence recognized among spectrum natural...
Depression often coexists with cardiovascular disease, such as hypertension and heart failure, in which sympathetic hyperactivation is critically involved. Reduction the brain sigma-1 receptor (S1R) functions depression pathogenesis via neuronal activity modulation. We hypothesized that reduced S1R exacerbates especially pressure overload worsening depression.Male Institute of Cancer Research mice were treated aortic banding and, 4 weeks thereafter, fed a high-salt diet for an additional to...
Increase in cerebrospinal fluid (CSF) Na+ concentration ([Na+]) precedes hypertension and is a key step the development of salt-induced hypertension. In choroid plexus (CP), epithelial channels (ENaCs) have an important role transport from blood into CSF. However, it remains unknown whether mineralocorticoid receptors (MR)/ENaCs pathway CP stroke-prone spontaneously hypertensive rats (SHRSP) involved neural mechanisms Therefore, we examined MR/ENaCs SHRSP associated with increase CSF [Na+]....
Recently, there has been increasing concern about adverse health effects of exposure to desert dust events. However, the association between and incidence ischemic heart diseases is unknown. The aim present study was elucidate whether Asian (AD), a windblown sand originating from mineral soil in China Mongolia, associated with acute myocardial infarction (AMI).We investigated data regarding hospitalization because AMI among 3068 consecutive patients 4 centers Fukuoka, Japan, for AD April...
We previously demonstrated that higher simple guideline-directed medical therapy (GDMT) scores (comprising renin-angiotensin system inhibitors, β-blockers, mineralocorticoid antagonists, and sodium-glucose cotransporter 2 inhibitors) at discharge were correlated with improved prognosis in heart failure (HF) patients. HF readmissions are linked to adverse outcomes, emphasizing the need for enhanced optimization of GDMT.
The guideline-directed medical therapy (GDMT) has been recommended for heart failure (HF) with reduced ejection fraction (HFrEF) based on the accumulating clinical evidence. However, it is difficult to implement all trial-proven medications every patient in real world.A simple GDMT score was created, according combination of drugs (renin-angiotensin system inhibitors, beta-blockers, mineralocorticoid receptor antagonists, and sodium-glucose transporter 2 inhibitors) administration their...
Neuregulin-1 (NRG-1), located in the central nervous system (CNS), plays an important role synaptic function, neurite outgrowth, and survival of neurons glia acting on ErbB receptor family. However, functional NRG-1/ErbB signaling CNS blood pressure regulation is unknown, particularly rostral ventrolateral medulla (RVLM), a major vasomotor center. Thus, we investigated whether RVLM involved regulation.Microinjection NRG-1 into decreased arterial pressure, heart rate (HR), renal sympathetic...
Malnutrition is highly prevalent in patients with heart failure (HF), but the precise impact of dietary energy deficiency on HF patients’ clinical outcomes not known. We investigated associations between inadequate calorie intake and adverse events 145 stable outpatients chronic who had a history hospitalization due to worsening HF. To assess pattern, we used brief self-administered diet-history questionnaire (BDHQ). Inadequate was defined as <60% estimated requirement. In total cohort,...
It has been reported that congestive heart failure (CHF) readmission not decreased in the last decade. is also CHF likely to occur shortly after discharge. We investigated whether an early follow-up at outpatient care within 2 weeks discharge affects long-term rate and prognosis.We reviewed consecutive 1002 patients admitted our hospital due CHF. Two-hundred fifty-nine who died in-hospital or were transferred another readmitted excluded 743 of discharged analysed. extracted contributing...
Objectives: Enhanced central sympathetic outflow is an indicator of the prognosis heart failure. Although sympatholytic drug moxonidine established therapeutic strategy for hypertension, its benefits hypertensive failure are poorly understood. In present study, we investigated effects sympathoinhibition by intracerebral infusion on survival in a rat model and possible mechanisms involved. Methods results: As failure, fed Dahl salt-sensitive rats 8% NaCl diet from 7 weeks age....
We recently reported that activation of neuregulin-1 (NRG-1)/ErbB signaling in the rostral ventrolateral medulla (RVLM) brainstem elicits sympathoinhibition and depressor effects, ErbB2-type ErbB receptors are involved neurogenic mechanisms hypertension. Nitric oxide (NO) RVLM also effects. NRG-1 enhances NO synthase (NOS) expression several tissues. Here, we tested hypothesis ErbB2 inhibition contributes to increasing blood pressure via modulating effects NOS. measured chronic...
Neuregulin-1 (NRG-1)/ErbB signaling in the heart is reported to have a crucial role failure. We recently demonstrated that NRG-1 has sympathoinhibitory effects brain cardiovascular control center. How this central impacts sympathoexcitation failure, however, unknown. Here we examined of NRG-1/ErbB modulating sympathetic nervous system pressure overload-induced failure.Pressure failure was induced Wistar-Kyoto rats by banding abdominal aorta. Rats were followed up for 15 weeks. Compared...
The aim of this study was to assess specialty-related differences in the treatment for patients with acute heart failure (AHF) phase and subsequent prognostic differences.
Background: The efficacy of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in patients with acute chronic heart failure (HF) is increasingly being reported. However, it not clear when SGLT2i should be initiated decompensated HF (ADHF) after hospitalization. We retrospectively analyzed ADHF newly prescribed SGLT2i. Methods and Results: Among the 694 hospitalized due to between May 2019 2022, data were extracted for 168 during index These divided into groups: early group (92 who started...
Pressure overload enhances salt-induced sympathoexcitation through hypothalamic mineralocorticoid receptor (MR)-epithelial Na channel activation. also increases angiotensin type 1 receptors (AT1R). However, the role of AT1R in pressure overload-induced MR activation and remains unknown. Therefore, aim present study was to address this question. We performed aortic banding (AB) on mice from Institute Cancer Research. The expression MR, serum/glucocorticoid-induced protein kinase-1 (SGK-1)...