A5011124442- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Aortic aneurysm repair treatments
- Cardiac Arrest and Resuscitation
- Cardiac pacing and defibrillation studies
- Infectious Aortic and Vascular Conditions
- Transplantation: Methods and Outcomes
- Cardiac tumors and thrombi
- Tissue Engineering and Regenerative Medicine
- Central Venous Catheters and Hemodialysis
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Congenital Heart Disease Studies
- Trauma Management and Diagnosis
- Polymer Surface Interaction Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Fuel Cells and Related Materials
- Biliary and Gastrointestinal Fistulas
- Blood Coagulation and Thrombosis Mechanisms
- Vascular Procedures and Complications
- Renal and Vascular Pathologies
- Diverticular Disease and Complications
Shizuoka Medical Center
2024-2025
NYU Langone Health
2022-2024
Health First
2022
Carnegie Mellon University
2018-2021
National Cerebral and Cardiovascular Center
2015-2019
Massachusetts General Hospital
2019
The University of Tokyo
2017-2019
Noritsu (Japan)
2015-2016
University of Tokyo Hospital
2016
Gunma Prefectural Cardiovascular Center
2014
Blood contact with high surface area medical devices, such as dialysis and extracorporeal life support (ECLS), induces rapid coagulation. Systemic anticoagulation, heparin, is thus necessary to slow clot formation, but some patients suffer from bleeding complications. Both problems might be reduced by 1) replacing heparin anticoagulation artificial inhibition of the protein adsorption that initiates coagulation 2) selective intrinsic branch cascade. This approach was evaluated comparing...
Background: This network meta-analysis compares outcomes of optimal medical therapy (OMT) and pre-emptive thoracic endovascular aortic repair (TEVAR) for uncomplicated type B dissection at different phases chronicity. Methods: MEDLINE EMBASE were searched through November 2023. Pooled short-term (short-term mortality, perioperative complications) long-term (all-cause aortic-related re-intervention rates) calculated. Results: Systematic review identified 17 studies (2 randomized controlled...
This meta-analysis evaluates outcomes in patients undergoing bioprosthetic aortic valve replacement (bAVR), comparing different antithrombotic strategies. We conducted a systematic search through May 2024. A standard compared between who received anticoagulation therapy (AC) and those did not. Therapeutic categories were subdivided into four groups: AC alone, with antiplatelet (AP), AP no therapy. network was performed for these categories. The review included 16 studies, comprising total of...
While thoracic endovascular aortic repair (TEVAR) for type B dissection is widely used, its use in cases of A acute syndrome remains limited. This meta-analysis was conducted to determine the outcomes TEVAR retrograde intramural hematoma (IMH) and with intimal disruption located descending aorta. Systematic searches were up April 2024. Pooled proportions perioperative late computed. Additionally, standard mean differences (SMD) 95% confidence intervals (CI) dimensions following calculated....
Background: This meta-analysis aimed to compare postoperative outcomes between endovascular and surgical revascularization of the left subclavian artery (LSA) in patients undergoing thoracic aortic repair (TEVAR). Methods: We performed a comprehensive search MEDLINE EMBASE databases through February 2024. Pooled results were calculated, subgroup analyses focused on chimney technique for LSA revascularization. Kaplan–Meier curves mid-term all-cause mortality reconstructed by extracting...
Abstract This meta-analysis aimed to compare short-term outcomes in patients undergoing minimally invasive cardiac surgery (MICS) using endoaortic balloon (EAB) and transthoracic aortic clamp (TAC) techniques. A comprehensive search of relevant databases was conducted through July 2024. Pooled results were calculated, subgroup analyses studies published during early late eras performed. Additionally, a meta-regression analysis based on the year publication assess potential influences...
Continuous-flow left ventricular assist devices (CF-LVADs) are widely used to treat patients with end-stage heart failure. Although continuous flow is different from physiological flow, show improved outcomes after CF-LVAD implantation. A novel rotational speed (RS) modulation system (EVAHEART) has been developed, which can change RS in synchronization the native cardiac cycle. We conducted present study investigate influence of on pulsatility peripheral perfusion.We implanted EVAHEART at...
Abstract We have developed a rotational speed ( RS ) modulation system for continuous‐flow left ventricular assist device EVAHEART that can change in synchronization with patient's electrocardiogram. Although is considered not to cause significant acquired von Willebrand syndrome, there remains concern the repeated acceleration and deceleration of impeller may degrade factor vWF multimers. Accordingly, we evaluated influence our on dynamics. A simple mock circulation was used. The filled...
Tissue-engineered heart valves (TEHVs) are expected to be viable grafts. However, it is unknown whether they transit their histological structure after implantation. We developed a novel autologous TEHV (named stent biovalve) for transcatheter implantation, using in-body tissue engineering based on encapsulation phenomenon. In this study, time-course transition of implanted biovalves was investigated in goats. Three types were prepared by 2 month embedding plastic molds mounted with metallic...
Excessive left ventricular (LV) volume unloading can affect right (RV) function by causing a leftward shift of the interventricular septum in patients with mitral regurgitation (MR) receiving assist device (LVAD) support. Optimal settings for LVAD should be chosen to appropriately control MR without RV dysfunction. In this study, we assessed utility our electrocardiogram-synchronized rotational speed (RS) modulation system along continuous-flow goat model MR. We implanted EVAHEART devices...
Fulminant myocarditis is a life-threatening disease, and myocardial damage expands the right ventricle as well left in some cases. There mortality rate of over 40% patients with fulminant who need mechanical circulatory support by peripheral venoarterial extracorporeal membrane oxygenation.We report case 27-year-old Japanese woman was successfully bridged to recovery using biventricular assist device. She diagnosed myocarditis, oxygenation established on same day. Her ventricular ejection...
We developed a novel miniaturized extracorporeal centrifugal pump "BIOFLOAT NCVC (Nipro Corporation Osaka, Japan) as ventricular assist device (VAD) and performed preclinical study that is part of the process for its approval bridge to decision by pharmaceutical medical agencies. The aim this was assess postoperative performance, hemocompatibility, anticoagulative status during an extended period use. A VAD system, consisting hydrodynamically levitated pump, measuring 64 mm 131 in size...
A 72-year-old man was referred to our department for evaluation and treatment of pulmonary embolism by a foreign body. He underwent lumbar spine surgery spinal canal stenosis. The surgeons noticed piece rubber catheter used cover tip surgical suction missing during procedures. Lumbar X-ray taken in the operation room revealed body just anterior spine. thought have migrated inferior vena cava …
上行大動脈の偽腔が開存していた(上行大動脈偽腔開存型の)逆行性A型急性大動脈解離に対して,胸部下行大動脈のentryを閉鎖する目的で,発症当日に緊急胸部大動脈ステントグラフト内挿術を行い,術後の造影CT検査で上行から近位胸部下行大動脈の偽腔が,術後に完全に血栓化し縮小(真腔が拡大)して消失した,49歳・男性の症例を経験したので報告する.上行大動脈偽腔開存型の逆行性A型急性大動脈解離に対する胸部大動脈ステントグラフト内挿術は,体外循環・心停止・低体温循環停止などを伴う大動脈置換に比べはるかに低侵襲であり,entryが左鎖骨下動脈分岐部から少なくとも2 cm程度以上は末梢に位置するような,限られた症例には有用な治療になる可能性がある.