A5000883137- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Pancreatic and Hepatic Oncology Research
- Breast Cancer Treatment Studies
- Barrier Structure and Function Studies
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Colorectal Cancer Screening and Detection
- Global Cancer Incidence and Screening
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Breast Lesions and Carcinomas
- Metastasis and carcinoma case studies
- Neuroendocrine Tumor Research Advances
- AI in cancer detection
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Mechanical Circulatory Support Devices
- Prostate Cancer Treatment and Research
- Actinomycetales infections and treatment
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Cancer, Stress, Anesthesia, and Immune Response
- Polymer Surface Interaction Studies
UPMC Hillman Cancer Center
2020-2025
University of Pittsburgh
2020-2025
Women's Cancer Center of Nevada
2024
Cancer Research Center
2020-2024
Weatherford College
2024
University of Pittsburgh Medical Center
2020-2024
Magee-Womens Research Institute
2020-2024
Carnegie Mellon University
2016-2023
National Student Clearinghouse Research Center
2022
Allegheny Health Network
2012-2020
Abstract Background There is increasing interest in better understanding the biology and clinical presentation of invasive lobular cancer (ILC), which most common special histological subtype breast cancer. Limited large contemporary data sets are available allowing comparison clinicopathologic features between ILC ductal (IDC). Methods The Great Lakes Breast Cancer Consortium was formed to compare behavior (n = 3617) IDC 30 045) from 33 662 patients treated 1990 2017 at 3 centers. We used...
Blood contact with high surface area medical devices, such as dialysis and extracorporeal life support (ECLS), induces rapid coagulation. Systemic anticoagulation, heparin, is thus necessary to slow clot formation, but some patients suffer from bleeding complications. Both problems might be reduced by 1) replacing heparin anticoagulation artificial inhibition of the protein adsorption that initiates coagulation 2) selective intrinsic branch cascade. This approach was evaluated comparing...
Invasive lobular breast carcinoma (ILC), one of the major cancer histologic subtypes, exhibits unique features compared with well-studied ductal subtype (IDC). The pathognomonic feature ILC is loss E-cadherin, mainly caused by inactivating mutations, but contribution this genetic alteration to ILC-specific molecular characteristics remains largely understudied. To profile these transcriptionally, we conducted single-cell RNA sequencing on a panel IDC and cell lines, an line (T47D)...
ABSTRACT Spatial transcriptomics provides insights into tissue architecture by linking gene expression with spatial localization. Current deconvolution methods rely heavily on single-cell RNA sequencing (scRNA-seq) references, which are costly and often unavailable, mainly if the under evaluation is limited, such as in a core biopsy specimen. We present novel tool, CITEgeist, that deconvolutes data using antibody capture from same slide reference, directly leveraging cell surface protein...
Background and study aims Endoscopic ultrasound-directed transgastric endoscopic retrograde cholangiopancreatography (ERCP) (EDGE) is a novel technique for managing pancreaticobiliary diseases in patients with history of Roux-en-Y Gastric Bypass (RYGB). It has shown to have high technical success rates fewer adverse events as compared laparoscopic-assisted ERCP (LA-ERCP). We the clinical outcomes EDGE vs. LA-ERCP E-ERCP. Patients methods A retrospective chart review was performed 56...
<h3>Importance</h3> Overtreatment of early-stage breast cancer with favorable tumor biology in older patients may be harmful without affecting recurrence and survival. Guidelines that recommend deimplementation sentinel lymph node biopsy (SLNB) (Choosing Wisely) radiotherapy (RT) (National Comprehensive Cancer Network) have been published. <h3>Objective</h3> To describe the use rates association disease SLNB RT women cancer. <h3>Design, Setting, Participants</h3> This cohort study obtained...
The aim of this study was to evaluate depression in pancreatic cancer (PC) patients before and after a diagnosis using US-based healthcare database. We also sought the impact treatment PC on all-cause mortality.Pancreatic with comorbid Explorys (1999-2019) were compared controls odds ratios 95% confidence intervals. Rates diagnosed within 6 months, 1 year, 3 years recorded. Patients who developed further categorized into those treated for mental health professionals (MHPs), pharmacologic...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA New Allenyl Bonding Mode in Binuclear Complexes: Characterization and Molecular Structures of M2(CO)6(.mu.-PPh2)(.mu.-.eta.1:.eta.2.beta..gamma.-C(Ph():C:CH2) (M = Ru, Os)Neil Carleton, John F. Corrigan, Simon Doherty, Robin Pixner, Yan Sun, Nicholas J. Taylor, Arthur CartyCite this: Organometallics 1994, 13, 11, 4179–4182Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November...
Abstract Background Endoscopic ultrasound (EUS) guided core needle biopsies (CNB) are increasingly being performed to diagnose solid pancreatic lesions. However, studies have been conflicting in terms of CNB improving diagnostic accuracy and procedural efficiency vs fine‐needle aspiration (FNA), which this study aims elucidate. Methods Data were prospectively collected on consecutive patients with or peripancreatic lesions at a single tertiary care center from November 2015 2016 that...
Background There are few tissue‐based biomarkers that can accurately predict prostate cancer (PCa) progression and aggressiveness. We sought to evaluate the clinical utility of breast overexpressed 1 (PBOV1) as a potential PCa biomarker. Methods Patient tumor samples were designated by Grade Groups using 2014 Gleason grading system. Primary radical prostatectomy tumors obtained from 48 patients evaluated for PBOV1 levels Western blot analysis in matched benign cancer‐adjacent regions....
The CDK4/6 inhibitor, abemaciclib, is now the standard of care adjuvant therapy for patients with estrogen receptor-positive (ER+)/human epidermal growth factor receptor 2-negative (HER2-) tumors at high risk recurrence. Real-world usage uncovers emerging side effects that may have been previously unreported in clinical trials. Here, we present course a patient who developed syndrome inappropriate antidiuretic hormone (SIADH) without underlying kidney injury due to abemaciclib use.
PURPOSE Natural language understanding (NLU) may be particularly well equipped for enhanced data capture from the electronic health record given its examination of both content-driven and context-driven extraction. METHODS We developed applied a NLU model to examine rates pathological node positivity (pN+) lymphedema determine whether omission routine axillary staging could extended younger patients with estrogen receptor–positive (ER+)/cN0 disease. RESULTS found that pN+ arm were similar...
Abstract Motivation Biomarker detection plays a pivotal role in biomedical research. Integrating omics studies from multiple cohorts can enhance statistical power, accuracy and robustness of the results. However, existing methods for horizontally combining are mostly designed two-class scenarios (e.g., cases versus controls) not directly applicable with multi-class design samples disease subtypes, treatments, tissues, or cell types). Results We propose framework, namely Mutual Information...
We evaluated differences in long-term outcomes of invasive lobular carcinoma (ILC) vs breast cancers no special type (NST) treated with anthracycline-based adjuvant chemotherapy using 4 National Surgical Adjuvant Breast and Bowel Project (NSABP) randomized phase III trials (B-22, B-25, B-28, B-30). Our cohort included 11,251 patients NST 1,231 ILC. Patients ILC were older, had larger more often estrogen receptor-positive tumors, positive lymph nodes. During early follow-up (0-5 years), fewer...