A5101999882- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Fibroblast Growth Factor Research
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Kruppel-like factors research
- Eosinophilic Disorders and Syndromes
- Organ Donation and Transplantation
- Immune Cell Function and Interaction
- Synthesis and biological activity
- MicroRNA in disease regulation
- Synthesis and Characterization of Heterocyclic Compounds
- Curcumin's Biomedical Applications
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Parvovirus B19 Infection Studies
- Transplantation: Methods and Outcomes
- Animal Virus Infections Studies
- Molecular Biology Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
- Liver Disease and Transplantation
First Hospital of China Medical University
2011-2021
China Medical University
2011-2021
Wenzhou Medical University
2017-2019
Kyoto University
2008
St. Mary's Hospital
1992-1993
St Mary's Hospital
1993
St Mary's Hospital
1992
Queen Elizabeth the Queen Mother Hospital
1992
Some experimental transplant-tolerance models have shown that the presence of regulatory T cells within grafts is important for development tolerance (Tol). METHODS.: To determine if correlates with graft acceptance in living-donor liver-transplantation tolerance, expression Foxp3 mRNA and CD4, CD8, were quantified biopsies from tolerant recipients by real-time polymerase chain reaction immunohistochemistry immunofluorescent staining (Gr-Tol). The results compared on maintenance...
Background. Operational tolerance is defined as long-term acceptance of a transplanted organ after complete cessation immunosuppression (IS), but may not always protect against antigen-dependent changes in graft morphology. Method. IS free patients living-donor liver transplantation (LDLT) underwent protocol biopsy (tolerance group [Gr-Tol]) and were evaluated for rejection fibrosis. The degree fibrosis was compared with those the on maintenance (Gr-IS) base line normal (Gr-BS). When...
Purpose. Treatment outcomes for advanced liver cancer are poor. Immunotherapy is a treatment strategy that has been widely used to treat other cancers. Studies have shown CD8+ T lymphocytes essential factors affecting the efficacy of immunotherapy. We computational biology methods determine coexpressed gene network promotes lymphocyte infiltration. Method. obtained matrix and clinical follow-up information data from TCGA hepatocellular carcinoma FPKM. single nucleotide polymorphism (SNP)...
Breast invasive carcinoma (BRCA) is a complex polygenic disease characterized by molecular and histological heterogeneity. An effort underway to explore investigate multiple reliable prognostic markers improve management of BRCA patients provide novel therapeutic targets. The aim the study identify miRNA signature in patients.The miRNA-sequencing data clinical information were downloaded from Cancer Genome Atlas (TCGA) database.A total 106 differentially expressed miRNAs identified between...
A series of 4-bromo-N-(3,5-dimethoxyphenyl)benzamide derivatives were designed and synthesised as novel fibroblast growth factor receptor-1 (FGFR1) inhibitors. We found that one the most promising compounds, C9, inhibited five non-small cell lung cancer (NSCLC) lines with FGFR1 amplification, including NCI-H520, NCI-H1581, NCI-H226, NCI-H460 NCI-H1703. Moreover, IC50 values for compound C9 1.36 ± 0.27 µM, 1.25 0. 23 2.31 0.41 2.14 0.36 µM 1.85 0.32 respectively. The arrested cycle at G2...
We report the cloning and sequencing of putative structural region hepatitis C virus (HCV) genome (2229 nucleotides) from an isolate derived a British case chronic sporadic non-A, non-B hepatitis. The overall sequence shows higher similarity with one type HCV, HCV1 (92%), than HCV2 (80%), is very highly conserved at 5' end (99%) preceding long open reading frame, well also in core (90 to 97%), but marked variation envelope region, particularly 2/non-structural 1 (70%). gene was cloned pJ3...
The conventional tube test (CTT) and microcolumn gel card (MG) were used to measure immunoglobulin G (IgG) antibody titres blood group A (anti-A) B (anti-B) in 288 serum samples. Diagnostic concordance correlations between the two methods analysed. MG was more sensitive than CTT detection of both anti-A anti-B IgG. Correlation coefficients for titration 0.8470 0.8336, respectively. regression equation representing relationship calculated convert critical values IgG antibodies determined by...
Abstract A total of 24 N‐substituted 3,5‐bis(2‐(trifluoromethyl)benzylidene)piperidin‐4‐one derivatives were synthesized via aldol condensation, and their anti‐inflammatory activities evaluated. These compounds found to have no significant cytotoxicity against mouse bone marrow cells in vitro. However, some compounds, such as c6 ( N ‐(3‐methylbenzoyl)‐3,5‐bis‐(2‐(trifluoromethyl)benzylidene)piperidin‐4‐one) c10 ‐(2‐chlorobenzoyl)‐3,5‐bis‐(2‐(trifluoromethyl)benzylidene)piperidin‐4‐one),...
Background: Thienopyrimidinone is a newly designed, selective fibroblast growth factor receptor 1 (FGFR1) inhibitor with an excellent anticancer effect. Objective: The goal of the present study was to design and synthesize better FGFR1 inhibitors through modifications lead compound thienopyrimidinone. Methods: In study, series C-2 substituted derivatives thienopyrimidinone, namely L1–L16, were synthesized, their inhibitory effects on evaluated. anti-proliferative activities these compounds...
Objective To summarize our experience in the liver transplantation from donation after cardiac death (DCD).Methods The livers three DCD donors (2 cases of brain trauma and 1 case cerebral hemorrhage) were harvested according to Guidelines for Donation Cardiac Death China.These grafts orthotopically transplanted into recipients including 2 decompensative hepatic cirrhosis primary cancer.The warm ischemic time ranged 7.5 10 min cold was 4.5,8.2 6.5 h respectively.Postoperative...