A5049158124- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Mitochondrial Function and Pathology
- Marine Invertebrate Physiology and Ecology
- Redox biology and oxidative stress
- Inflammasome and immune disorders
- Cancer, Hypoxia, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
Institut de Pharmacologie et de Biologie Structurale
2025
University College London
2022-2023
Great Ormond Street Hospital
2022
Abstract In 2020–2021, a “mysterious illness” struck Senegalese fishermen, causing severe acute dermatitis in over one thousand individuals following exposure through drift-net fishing activity. Here, by performing deep analysis of the environmental samples we reveal presence marine dinoflagellate Vulcanodinium rugosum and its associated cyclic imine toxins. Specifically, show that toxin PortimineA, strongly enriched samples, impedes ribosome function human keratinocytes, which subsequently...
Abstract Lung infections are one of the leading causes death worldwide, and this situation has been exacerbated by emergence COVID-19. Pre-clinical modelling viral relied on cell cultures that lack 3D structure context lung extracellular matrices. Here, we propose a bioreactor-based, whole-organ model infection. The bioreactor takes advantage an automated system to achieve efficient decellularization whole rat lung, recellularization scaffold using primary human bronchial cells....