A5101446689- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Esophageal and GI Pathology
- Cardiovascular Syncope and Autonomic Disorders
- Bone Tissue Engineering Materials
- Vagus Nerve Stimulation Research
- Graphene and Nanomaterials Applications
- Obstructive Sleep Apnea Research
- Nigella sativa pharmacological applications
- Barrier Structure and Function Studies
- Central Venous Catheters and Hemodialysis
- Connexins and lens biology
- Mesenchymal stem cell research
- Renal and related cancers
- Chemotherapy-induced organ toxicity mitigation
- Liver physiology and pathology
- Dialysis and Renal Disease Management
- Cancer and Skin Lesions
- Salivary Gland Tumors Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Neurological Disease Mechanisms and Treatments
- Vascular Procedures and Complications
- Orthopedic Surgery and Rehabilitation
- 3D Printing in Biomedical Research
- Veterinary Equine Medical Research
University College London
2023
Great Ormond Street Hospital
2023
Assiut University
2018-2021
Kangwon National University
2018-2020
Charité - Universitätsmedizin Berlin
2020
Research Institute of Ophthalmology
2019
Abstract Whole kidney decellularization is a promising approach in regenerative medicine for engineering functional organ. The reaction of the potential host depends on biocompatibility these decellularized constructs. Despite proven ability scaffolds to guide cell attachment and growth, little known about hemocompatibility scaffolds. Our aim prepare kidneys clinically relevant size evaluate its hemocompatibility. Porcine were cannulated via renal artery, then perfused with 0.1% sodium...
No ideal cross-linking agent has been identified for decellularized livers (DLs) yet. In this study, we evaluated structural improvements and biocompatibility of porcine DLs after with silver nanoparticles (AgNPs). Porcine liver slices were then loaded AgNPs (100 nm) optimization the highest non-toxic concentration (5 µg/mL) using Human hepatocellular carcinoma (HepG2) EAhy926 human endothelial cell lines. The effect was compared to that glutaraldehyde ethyl carbodiimide hydrochloride...
<b><i>Background/Aims:</i></b> All hemodialysis (HD) patients are generally recommended to create a fistula first; but mature arteriovenous (AVF) can be challenging in elderly individuals. It is unclear if incident HD derive survival benefit from an AVF over graft (AVG) or tunneled central venous catheter (TDC). <b><i>Methods:</i></b> We examined the association of vascular access type (AVF, AVG, and TDC with without maturing AVF/AVG at...
Abstract The generation of a transplantable liver scaffold is crucial for the treatment end‐stage failure. Unfortunately, decellularized scaffolds suffer from lack bioactive molecules and functionality. In this study, we conjugated homogenized liver‐extracellular matrix (ECM) into in rat model to improve its structural functional properties. ECM was prepared, characterized, subsequently perfused ethyl carbodiimide hydrochloride (EDC)/ N ‐hydroxysuccinimide (NHS) activated scaffolds. Various...
Abstract Acute liver failure (ALF) occurs due to severe damage that triggers rapid loss of normal function. Here, we investigate the usefulness an injectable extracellular matrix (LECM)‐rich hydrogel generated from optimized decellularization protocol incorporated with silver nanoparticles (AgNPs) as a promising therapy for ALF. First, non‐destructive rat obtain ECM‐rich well‐preserved scaffold. Then, LECM two commonly used protocols were compared by obtained our protocol. The ALF model was...
Empirical antibiotic treatment is a common practice to manage chronic dacryocystitis in many healthcare settings spite of the probability for changing types microbial isolates. The aims this study were find out current clinicomicrobiological profile adult cases with and determine antibiogram isolated organisms commonly prescribed antibiotics. Of 25 samples obtained, 15 (60%) yielded positive culture, 12 (48%) showed single bacterial isolate while 3 (12%) had mixed (two types) A total 18...
Abstract Purpose of Review To describe experimental liver injury models used in regenerative medicine, cell therapy strategies to repopulate damaged livers and the efficacy bioengineering. Recent Findings Several animal have been developed study different conditions. Multiple modified protocols delivery also reported. Furthermore, using bioengineered scaffolds has shown promising results that could help generating a highly functional system and/or whole transplantable liver. Summary optimize...
Patients affected by microgastria, severe gastroesophageal reflux, or those who have undergone subtotal gastrectomy, commonly described reporting dumping syndromes other symptoms that seriously impair the quality of their life. Gastric tissue engineering may offer an alternative approach to treating these pathologies. Decellularization protocols great potential generate novel biomaterials for large gastric defect repair. There is urgency define more reliable foster clinical applications...