A5035501868- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- RNA modifications and cancer
- Metabolism and Genetic Disorders
- Fuel Cells and Related Materials
- RNA regulation and disease
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- High Altitude and Hypoxia
University of Padua
2021-2025
Neuroscience Institute
2023
F-ATP synthase is a leading candidate as the mitochondrial permeability transition pore (PTP) but mechanism(s) to channel formation remain undefined. Here, shed light on structural requirements for PTP formation, we test cells ablated g, OSCP and b subunits, ρ0 lacking subunits A6L. Δg (that also lack subunit e) do not show opening in intact or patch-clamped mitoplasts unless atractylate added. Δb ΔOSCP display currents insensitive cyclosporin A inhibited by bongkrekate, suggesting that...
Abstract The permeability transition (PT) is a increase of the mitochondrial inner membrane causing swelling in response to matrix Ca 2+ . PT mediated by regulated channel(s), pore(s) (PTP), which can be generated at least two components, adenine nucleotide translocator (ANT) and ATP synthase. Whether these provide independent permeation pathways remains established. Here, we assessed contribution ANT based on effects selective inhibitors atractylate (ATR) bongkrekate (BKA), trigger inhibit...
Oxygen deprivation or hypoxia is poorly dealt with by most terrestrial species and often leads to permanent tissue damage death. One prominent exception the naked mole-rat (Heterocephalus glaber) which remarkably adapted withstand prolonged periods (~18 mins) of severe hypoxia, a trait likely driven its crowded underground lifestyle. Other African are less social entirely solitary like Cape (Georychus capensis). Here, we asked whether cellular molecular adaptations map traits. We discovered...