A5103096143- Ion channel regulation and function
- Erythrocyte Function and Pathophysiology
- Chemical and Physical Studies
- Plant and Biological Electrophysiology Studies
Max Delbrück Center
2023-2024
Touch perception is enabled by mechanically activated ion channels, the opening of which excites cutaneous sensory endings to initiate sensation. In this study, we identify ELKIN1 as an channel likely gated mechanical force, necessary for normal touch sensitivity in mice. insensitivity
Abstract The slightest touch to the skin initiates tactile perception that is almost immediate 1 . extraordinary speed of enabled by mechanically-activated ion channels, opening which excites endings sensory neurons innervating initiate sensation. Here we identify a new channel, Elkin1 2 , that, when ablated in mice, leads profound behavioural insensitivity. Touch insensitivity -/- mice was caused loss currents (MA-currents) around half all are activated light (low threshold...