A5019177884- Metabolism and Genetic Disorders
- Cardiac Arrhythmias and Treatments
- Neonatal Respiratory Health Research
- Pharmacological Effects and Toxicity Studies
- Congenital Heart Disease Studies
- Cardiac pacing and defibrillation studies
- Neonatal and fetal brain pathology
- Hepatitis B Virus Studies
- Epilepsy research and treatment
- Family and Disability Support Research
- Family and Patient Care in Intensive Care Units
- Cystic Fibrosis Research Advances
- Child Nutrition and Feeding Issues
- Vaccine Coverage and Hesitancy
- Infant Development and Preterm Care
- Viral gastroenteritis research and epidemiology
- Liver Disease Diagnosis and Treatment
- Neonatal and Maternal Infections
- Helicobacter pylori-related gastroenterology studies
- Nosocomial Infections in ICU
- Clinical Nutrition and Gastroenterology
- Cardiovascular Syncope and Autonomic Disorders
- Childhood Cancer Survivors' Quality of Life
- Glycogen Storage Diseases and Myoclonus
- Trace Elements in Health
Uppsala University
2023
Bambino Gesù Children's Hospital
2010-2020
Istituti di Ricovero e Cura a Carattere Scientifico
2008-2020
Boston Children's Hospital
1996-2014
MRC Epidemiology Unit
2006-2012
Centre for Advanced Study
2011
University of Palermo
2006
Sapienza University of Rome
1998
No proven treatment exists for nonalcoholic fatty liver disease (NAFLD) in children and adolescents. We sought to determine the efficacy of lifestyle intervention with or without antioxidant therapy pediatric NAFLD. A total 53 patients (age 5.7-18.8 years, 37 boys) were included. Lifestyle consisting a diet tailored patient's calorie needs, increased physical activity was prescribed all. Patients concomitantly randomized alpha-tocopherol 600 IU/day plus ascorbic acid 500 mg/day (n = 25)...
The immunomodulatory properties of mesenchymal stromal cells are the subject increasing interest and widening clinical applications, but reproducibility their effects is controversial underlying mechanisms have not been fully clarified. We investigated transfer membrane vesicles, a recently recognized pathway intercellular communication, as possible mediator interaction between B lymphocytes. Mesenchymal exhibited strong dose-dependent inhibition B-cell proliferation differentiation in...
The aim of this study was to evaluate long-term outcome pacemakers (PMs) in paediatric patients.Patients' data were retrospectively reviewed. We recorded the techniques and systems used, any complication, outcome. Endocardial leads inserted by transcutaneous puncture subclavian vein fixed with a non-absorbable ligature, epicardial standard surgical technique. Lead survival calculated plotted product limit method Kaplan-Meier. Between 1982 2002, 292 patients, aged 8+/-7 years (range 1 day-18...
The purpose was to assess in Italy the clinical features at diagnosis of inflammatory bowel disease (IBD) children.In 1996 an IBD register onset established on a national scale.Up end 2003, 1576 cases pediatric were recorded: 810 (52%) ulcerative colitis (UC), 635 (40%) Crohn's (CD), and 131 (8%) indeterminate (IC). In period 1996-2003 increase incidence from 0.89 1.39/10(5) inhabitants aged <18 years observed. more frequent among children between 6 12 (57%) but 20% patients had under age;...
<h3>Objective</h3> To investigate the accuracy of procalcitonin (PCT) as a diagnostic marker nosocomial sepsis (NS) and define most accurate cut-off to distinguish infected from uninfected neonates. <h3>Setting</h3> Six neonatal intensive care units (NICUs). <h3>Patients</h3> 762 neonates admitted six NICUs during 28-month observational study for whom at least one serum sample was taken on admission. <h3>Main outcome measures</h3> Positive negative predictive values different PCT levels....
Prevalence of non-alcoholic fatty liver disease (NAFLD) among children is increasing dramatically. It unclear why some patients develop steatohepatitis (NASH), fibrosis and cirrhosis from steatosis, others do not. A role for leptin has been claimed. This study aims to evaluate the relationship between leptin, insulin resistance (IR) NAFLD in children.In 72 biopsy-proven (aged 9-18 years; 51M/21F), fasting its soluble receptor (sOB-R) were measured; free index (FLI) was calculated as...
To explore the clinical, electroencephalography (EEG), neuropsychological features, and prognosis of Panayiotopoulos syndrome (PS).Of 1,794 children aged between 1 14 years referred for first afebrile focal seizure, January 1992 December 2004, 93 (5.2%) had PS according to clinical criteria.Age at onset ranged from 1.1 8.6 years, was earlier in with more than one seizure. Autonomic seizures followed a stereotypical progression. Emesis, pallor, or flushing almost always among symptoms that...
To validate an Italian parental questionnaire designed to evaluate the neuropsychological and behavioural developmental status of 4-year-olds identify children in need further evaluation.The (Questionario per la valutazione dello Sviluppo di bambini a 4 anni - Genitori (QS4-G) ) consisted 93 questions divided into 10 areas: language, visual-motor abilities, memory/attention, fine gross motor self-help lateralisation, social skills, stress, sleep, alimentation evacuation. It was distributed...
To investigate adherence to dietary treatment and quality of life (QoL) in patients with phenylketonuria (PKU).In the setting a tertiary paediatric hospital, 41 early-treated affected by PKU aged more than 3 years old were enrolled cross-sectional study. Three-days assessment, QoL questionnaires for patients<18 (Child Health Questionnaire) Short Form adults completed.Of patients, 23 (56.1%) considered adherent prescriptions as their phenylalanine intake was less prescribed. Phenylalanine...
Nosocomial infections are still a major cause of morbidity and mortality among neonates admitted to neonatal intensive care units (NICUs).To describe the epidemiology nosocomial in NICUs assess risk infection related therapeutic procedures performed clinical characteristics at birth admission NICU, taking into account time between exposure onset infection.A multicenter, prospective cohort study.A total 1,692 6 Italy were observed monitored for development during their hospital stay.Data...
Respiratory syncytial virus (RSV) infection is the most common cause of bronchiolitis in infants and an important risk factor for development recurrent wheezing asthma. Cysteinyl leukotrienes were implicated pathophysiology these diseases, are being targeted their diagnosis therapy. We measured urinary leukotriene E4 (LTE4) with RSV comparison controls without respiratory infection, investigated whether medical family history, age, passive exposure to tobacco smoke related excretion. studied...
Parenteral nutrition (PN) is the primary treatment for intestinal failure, which considered irreversible in patients who remain partially or fully dependent on PN. Causes of failure are short bowel syndrome (SBS), motility disorders (MD), and severe protracted diarrhea (SPD). The aim this study was to report clinical outcome these relation underlying disease.From January 1, 1989 December 31, 2006, 218 were observed our center, but only 96 (48 SBS, 39 SPD, 9 MD) included because they required...