A5058847502- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Gene expression and cancer classification
- Circular RNAs in diseases
- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- Reproductive Biology and Fertility
- Statistical Methods and Inference
- Flood Risk Assessment and Management
- Regional resilience and development
- Statistical Methods and Bayesian Inference
- Genetic and phenotypic traits in livestock
- Infrastructure Resilience and Vulnerability Analysis
- Machine Learning and Data Classification
- Animal Genetics and Reproduction
- Molecular Biology Techniques and Applications
- Ecology and Vegetation Dynamics Studies
- Disaster Management and Resilience
- HIV/AIDS Research and Interventions
- Second Language Acquisition and Learning
- Political Conflict and Governance
- Statistical Methods in Clinical Trials
- HIV Research and Treatment
- Hydrology and Watershed Management Studies
- Genetics and Plant Breeding
Utah State University
2014-2023
Bristol City Council
2018-2021
East Carolina University
2018
Swedish Family Medicine Residency - Cherry Hill
2017
University of Wisconsin–Madison
2009
Purdue University West Lafayette
2005
St Mary's Hospital
1996
Hospital General Universitario Gregorio Marañón
1995
Chelsea and Westminster Hospital
1994
Wellcome Trust
1994
MicroRNAs (miRNAs) have been implicated in colorectal cancer (CRC) development and associated with prognostic indicators such as disease stage survival. Prognostic associations are often based on few individuals imprecise. In this study, we utilize population-based data from 1,141 CRC cases to replicate previously reported between 121 miRNAs The Agilent Human miRNA Microarray V19.0 was used generate following a stringent quality control protocol. Assessment of survival done using Cox...
MiRNAs are small, non-protein-coding RNA molecules that regulate gene expression either by post-transcriptionally suppressing mRNA translation or degradation. We examine differentially expressed miRNAs in colorectal carcinomas, adenomas and normal colonic mucosa. Data come from population-based studies of cancer conducted Utah the Kaiser Permanente Medical Care Program. A total 1893 carcinoma/normal-paired samples 290 adenoma tissue were run on Agilent Human miRNA Microarray V19.0 which...
The PI3K/AKT-signaling pathway is one of the most frequently activated signal-transduction pathways in cancer. We examined how dysregulated gene expression associated with miRNA this colorectal cancer (CRC). used data from 217 CRC cases to evaluate differential between paired carcinoma and normal mucosa identify miRNAs that are these genes. Gene RNA-Seq Agilent Human Microarray V19.0 were analyzed. focused on genes (fold change (FC) >1.5 or <0.67) statistically significant after adjustment...
OBJECTIVES: MicroRNAs (miRNAs) are small, non-protein-coding RNA molecules that commonly dysregulated in colorectal tumors. The objective of this study was to identify smaller subsets highly predictive miRNAs. METHODS: Data come from population-based studies cancer conducted Utah and the Kaiser Permanente Medical Care Program. Tissue samples were available for 1,953 individuals, which 1,894 had carcinoma tissue 1,599 normal mucosa statistical analysis. Agilent Human miRNA Microarray V.19.0...
The nuclear factor-kappa B (NF-κB) signalling pathway is a regulator of immune response and inflammation that has been implicated in the carcinogenic process. We examined differentially expressed genes this miRNAs to determine associations with colorectal cancer (CRC). used data from 217 CRC cases evaluate differences NF-κB gene expression between paired carcinoma normal mucosa identify are associated these genes. Gene RNA-Seq miRNA Agilent Human Microarray V19.0 were analysed. evaluated...
ABSTRACT Salmonella is an important cause of bacterial food-borne gastroenteritis. encounters multiple abiotic stresses during pathogen elimination methods used in food processing, and these may influence its subsequent survivability within the host or environment. Upon ingestion, exposed to gastrointestinal acidity, a first line innate defense system. This study tested hypothesis that encountered processing alter metabolic mechanisms enable survival persistence exposure acidic Out four...
In high dimensional data analysis (such as gene expression, spatial epidemiology, or brain imaging studies), we often test thousands more hypotheses simultaneously. As the number of tests increases, chance observing some statistically significant is very even when all null are true. Consequently, could reach incorrect conclusions regarding hypotheses. Researchers frequently use multiplicity adjustment methods to control type I error rates—primarily family-wise rate (FWER) false discovery...
Meta-analysis is a frequent tool among education and behavioral researchers to combine results from multiple experiments arrive at clear understanding of some effect interest. One the traditional assumptions in meta-analysis independence sizes studies under consideration. This article presents meta-analytic review 13 with 18 study reports all involving native-language (L1) vocabulary aids on second-language (L2) reading comprehension. Some produced reports, creating dependence structure...
A growing number of arenaviruses are known to cause viral hemorrhagic fever (HF), a severe and life-threatening syndrome characterized by fever, malaise, increased vascular permeability. Ribavirin, the only licensed antiviral indicated for treatment certain arenaviral HFs, has had mixed success significant toxicity. Since infections initially do not present with distinguishing symptoms difficult clinically diagnose at early stages, it is utmost importance identify therapies effective later...
Abstract Transcription factors (TFs) and microRNAs (miRNAs) regulate gene expression: TFs by influencing messenger RNA (mRNA) transcription miRNAs mRNA translation transcript degradation. Additionally, alter each other's expression, making it difficult to ascertain the effect either one has on target (TG) expression. In this investigation, we use a two‐way interaction model with TF miRNA as independent variables investigate whether work together influence TG expression levels in colon cancer...
Smoking is known to influence messenger RNA (mRNA) expression in colorectal cancer (CRC) cases. As microRNAs (miRNAs) are repressors of mRNAs, we hypothesize that smoking may miRNA expression, thus altering mRNA expression. Our sample consisted 1447 CRC cases had normal mucosa and carcinoma data lifestyle data. We examined current smoking, versus never former (C/F/N) smoking1, pack-years smoked with as well differential between paired tissue for colon rectal determine associations adjusted...
Climate change is increasing the frequency and intensity of extreme events and, consequently, flooding in urban peri-urban areas. The electrical grid exposed to an increase fault probability because its infrastructure was designed considering historical frequencies occurred past. In this respect, ensure future energy plans securing services great relevance determine evaluate new zones that may be under risk relation critical infrastructures for such events. regard, distribution system one...
MicroRNAs (miRNA) are small non-coding RNA involved in cellular processes, including cell proliferation and angiogenesis. Thus, miRNA expression may alter survival after diagnosis with colorectal cancer (CRC).Individuals diagnosed stage 1 or 2 rectal had worse than colon cases at 2. After adjustment for multiple comparisons, no miRNAs were significantly associated disease stage. Two infrequently expressed the population not previously reported (miR-1 HR 2.17 95% CI 1.41, 3.36; miR-101-3p...
AF Susceptibility in TGF‐β1 Transgenic Goats Introduction Large animal models of progressive atrial fibrosis would provide an attractive platform to study relationship between structural and electrical remodeling fibrillation (AF). Here we established a new transgenic goat model with cardiac specific overexpression investigated the changes structure function leading AF. Methods Results goats constitutively active were generated by somatic cell nuclear transfer. We examined myocardial tissue,...
Abstract Poor maternal nutrition during gestation can have immediate and life-long negative effects on offspring growth health. In livestock, this leads to reduced product quality increased costs of production. Based previous evidence that both restricted- overfeeding decrease muscle alter metabolism postnatally, we hypothesized poor would reduce the development prenatally, number myogenic progenitor cells, result in changes global expression genes involved prenatal function. Ewes were fed a...
The longitudinal Kerr magneto-optic technique proves to be well suited for the observation of domains in evaporated ferromagnetic thin films. In a series six films NiFe ranging thickness from 20 000 angstroms 500 angstroms, domain patterns have been photographed all but two thickest. Many features structure, familiar bulk single crystals, observed Certain unusual behavior appear characteristic thinnest specimens and also photographed. Complexities many patterns, uncorrelated with change film...
This paper outlines the work carried out within RESCCUE (RESilience to cope with Climate Change in Urban ArEas) project that is, part, examining impacts of climate-driven hazards on critical services and infrastructures cities. In this paper, we examined methods employed assess pluvial flooding events for varying return periods present-day (Baseline) future no adaptation measures applied (Business as Usual) conditions traffic flows Two cities were selected, Barcelona Bristol, former using a...
As the use of microarray technology becomes more prevalent it is not unusual to find several laboratories employing same identify genes related condition in species. Although experimental specifics are similar, typically a different list statistically significant result from each data analysis.We propose statistically-based meta-analytic approach analysis for purpose systematically combining results laboratories. This provides precise view that significantly interest while simultaneously...
Abstract: MicroRNAs (miRNAs) are small non-protein-coding RNA molecules that regulate gene expression. Diet and lifestyle factors have been hypothesized to be involved in the regulation of miRNA In this study it was diet associated with Data from 1,447 cases colorectal cancer evaluate 34 variables using expression normal mucosa as well for differential between paired carcinoma tissue were used. data obtained an Agilent platform. Multiple comparisons adjusted false discovery rate q -value....
Uncontrolled cell replication is a key component of carcinogenesis. MicroRNAs (miRNAs) regulate genes involved in checkpoints, DNA repair, and encoding for proteins regulating the cycle. We investigated how miRNAs mRNAs colorectal cancer subjects interact to Using RNA-Seq data from 217 individuals, we analyzed differential expression (carcinoma minus normal mucosa) 123 within cycle pathway with miRNA expression, adjusting age sex. Multiple comparison adjustments gene/miRNA associations were...