A5027572001- Neural and Behavioral Psychology Studies
- Child and Adolescent Psychosocial and Emotional Development
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health Research Topics
- Child Abuse and Trauma
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Posttraumatic Stress Disorder Research
- Neurobiology of Language and Bilingualism
- Decision-Making and Behavioral Economics
- Behavioral Health and Interventions
- Psychiatric care and mental health services
- Crime Patterns and Interventions
- Cognitive Abilities and Testing
- Traumatic Brain Injury Research
- Psychology of Moral and Emotional Judgment
- Suicide and Self-Harm Studies
- Stress Responses and Cortisol
- Nicotinic Acetylcholine Receptors Study
- Treatment of Major Depression
- Mental Health Treatment and Access
- Attachment and Relationship Dynamics
- Family Dynamics and Relationships
- Mental Health via Writing
Biomedical Research Institute
2023-2025
Virginia Tech
2011-2025
Roanoke College
2024
Salem VA Medical Center
2011-2023
Harvard University
2007-2011
Baylor University
2009
Harvard University Press
2001-2008
William James College
2007
Universität Ulm
1997
Words represent a uniquely human information channel-humans use words to express thoughts and feelings assign emotional valence experience. Work from model organisms suggests that assignments are carried out in part by the neuromodulators dopamine, serotonin, norepinephrine. Here, we ask whether signaling these extends word semantics humans measuring sub-second neuromodulator dynamics thalamus (N = 13) anterior cingulate cortex 6) of individuals evaluating positive, negative, neutrally...
Summary Prior research has linked content analysis drawn from text narratives to psychopathology in trauma survivors. This study used a longitudinal design determine whether linguistic elements of narrative memories first hearing about the events 11 September 2001 predict later post‐traumatic stress disorder (PTSD). Narratives and self‐report PTSD symptoms were collected within 1 week again 5 months after 9/11 40 undergraduates. People who more “we” words at Time had fewer acute symptoms....
The noradrenaline (NA) system is one of the brain's major neuromodulatory systems; it originates in a small midbrain nucleus, locus coeruleus (LC), and projects widely throughout brain.
Mood-congruent working memory biases were examined in a delayed matching to sample paradigm using the slow wave (SW) event-related brain potential (ERP) component. biases, indexed by SW amplitudes, demonstrated among individuals experiencing major depressive episode (MDE) and nondepressed controls but not with dysthymia. However, analyses of symptom severity that those dysthymia exhibited significantly less negative amplitudes increasing mood severity, whereas depression more severity. These...
Children and adolescents exposed to maltreatment are at a greater risk for substance use disorders in adulthood. However, developmental processes that explain how experiences may influence behaviors remain unclear. We investigated whether delay discounting (ie, the preference immediate over delayed rewards), critical indicator of self-regulation, serves as key mechanism linking use. used cascade model with dimensional approach test direct indirect effects neglect abuse on during adolescence...
Abstract The present study examined whether internalizing and externalizing symptoms may mediate the association between adolescent–mother adolescent–father attachment substance use. sample included 167 adolescents (47% girls) who were assessed at five time points with approximately 1 year each assessment, beginning in middle adolescence ( M age = 14.07) ending transition to young adulthood 18.39). reported their perceived both mother father during (Times 2), late 3 4), alcohol use (Time 5)....
In previous real-time functional magnetic resonance imaging neurofeedback (rtfMRI-NF) studies on smoking craving, the focus has been within-region activity or between-region connectivity, neglecting potential predictive utility of broader network activity. Moreover, there is debate over use and relative power individual-specific group-level classifiers. This study aims to further advance rtfMRI-NF for substance disorders by using whole-brain assess craving-related brain patterns, evaluate...
Abstract It is unclear how delay discounting and substance use develop across adolescence whether contextual factors alter their trajectories. The present study used a longitudinal design to examine socioeconomic status related developmental trajectories of adolescence. sample included 167 adolescents ( M age = 14 at Time 1; 53% male) parents who participated annually four years. Parents reported SES 1 completed behavioral assessments questionnaires Times 4. Bivariate latent growth curve...
Socioecological factors such as family environment and parenting behaviors contribute to the development of substance use. While biobehavioral synchrony has been suggested foundation for resilience that can modulate environmental effects on development, role brain similarity attenuates deleterious contexts not clearly understood. We tested whether parent-adolescent neural similarity—the level pattern between functional connectivity representing attunement within each dyad—moderates...
This study examined differential impact of the valence and arousal characteristics stimuli on memory biases brain activity in major depressive disorder (MDD) non-depressed control participants. P300 slow wave (SW) components event-related potential (ERP) were recorded 18 MDD individuals during encoding positive negative, high low words a free recall task. Control participants demonstrated expected enhanced for that was accompanied by corresponding increase SW ERP components. These effects...
Algorithmically defined aspects of reinforcement learning correlate with psychopathology symptoms and change symptom improvement following cognitive-behavioral therapy (CBT). Separate work in nonclinical samples has shown that varying the structure statistics task environments can learning. Here, we combine these literatures, drawing on CBT-based guided restructuring thought processes computationally mechanistic targets identified by reinforcement-learning models depression, to test whether...
Abstract Neuroscience research underscores the critical impact of adverse experiences on brain development. Yet, there is limited understanding specific pathways linking to accelerated or delayed development and their ultimate contributions psychopathology. Here, we present new longitudinal data demonstrating that neurocognitive functioning during adolescence, as affected by experiences, predicts psychopathology young adulthood. The sample included 167 participants (52% male) assessed in...
Greater neural similarity between parents and adolescents may reduce adolescent substance use. Among 70 parent-adolescent dyads, we tested a longitudinal path model in which family economic environment is related to use, directly indirectly through parental monitoring. Neural was measured as pattern functional brain connectivity at Time 1. Parents reported socioeconomic status monitoring Adolescents 1 use 2. Higher associated with greater similarity. lower mediated adolescent-perceived...
When making risky choices in social contexts, humans typically combine information with individual preferences about the options at stake. It remains unknown how such decisions are made when these inaccessible or disrupted, as might be case for individuals confronting novel experiencing cognitive impairment. Thus, we examined participants lesions insular dorsal anterior cingulate cortex, key regions implicated decision-making, they played a gambling task where were both alone and after...
Psychopathology, the science of mental dysfunctions, can and should be based on (cognitive) neuroscience.In particular, concepts such as neuronal activation, neuroplasticity, death used to understand, treat, dysfunctions. Some basic principles are illustrated using recent examples, plasticity serotonin system crab caused by a single social interaction, 'psychotherapy' specific language impairment effects stress hippocampus in human beings.
Childhood adversity and depression have been linked with heightened inflammation. However, few longitudinal studies examine how dimensions of maltreatment (i.e., abuse neglect) differentially impact pathways to inflammation internalizing symptoms. The present study examined effects neglect on (1) symptoms through inflammation, (2) across 3 years adolescence in the context COVID-19 pandemic. In a sample 78 adolescents, significant indirect revealed that childhood abuse, not neglect,...
Exposure and cognitive-based therapies are both effective for PTSD, but knowledge of which intervention is best patient lacking. This lack particularly noticeable group treatments, as no study has examined whether responses to different associated with pretreatment characteristics. Here, we explored levels three types psychological characteristics—PTSD symptom clusters, posttraumatic cognitions, emotion regulation difficulties—were reduction during group-delivered cognitive versus...