A5032040666- Neurotransmitter Receptor Influence on Behavior
- Neural and Behavioral Psychology Studies
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neuroscience and Music Perception
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Meningioma and schwannoma management
- Functional Brain Connectivity Studies
- Neurological diseases and metabolism
- Mental Health Research Topics
- Cancer, Hypoxia, and Metabolism
- Multisensory perception and integration
- Autism Spectrum Disorder Research
- Botulinum Toxin and Related Neurological Disorders
- Obsessive-Compulsive Spectrum Disorders
- Olfactory and Sensory Function Studies
- Receptor Mechanisms and Signaling
- Head and Neck Surgical Oncology
- Anesthesia and Sedative Agents
Wake Forest University
2019-2024
Winston-Salem State University
2023
In the mammalian brain, midbrain dopamine neuron activity is hypothesized to encode reward prediction errors that promote learning and guide behavior by causing rapid changes in levels target brain regions. This hypothesis (and alternatives regarding dopamine’s role punishment-learning) has limited direct evidence humans. We report intracranial, subsecond measurements of release human striatum measured, while volunteers (i.e., patients undergoing deep stimulation surgery) performed a...
From an early age, individuals with autism spectrum disorder (ASD) spend less time engaged in social interaction compared to typically developing peers (TD). One reason behind this behavior may be that the brains of children diagnosed ASD do not attribute enough value potential exchanges as children; thus, are avoided because other environmental stimuli more highly valued by default. Neurobiological investigations into mechanisms underlying value-based decision-making has shown ventral...
Introduction Currently, sub-second monitoring of neurotransmitter release in humans can only be performed during standard care invasive procedures like DBS electrode implantation. The procedure requires acute insertion a research probe and additional time surgery, which may increase infection risk. We sought to determine the impact our procedure, particularly extended on Methods screened 602 patients who had one or more codes documented for implantation, generator placement, programming,...
OBJECTIVE To the authors’ knowledge, no data have been reported on dopamine fluctuations subsecond timescales in humans with alcohol use disorder (AUD). In this study, release was monitored 2 patients and without a history of AUD during “sure bet or gamble” (SBORG) decision-making task to begin characterize how responses counterfactual information, related psychological notions regret relief, may be altered. METHODS Measurements extracellular levels were made once every 100 msec using human...
Decreasing dopaminergic function is at the core of Parkinson's disease (PD) motor symptoms and changes in action are associated with many comorbid non-motor PD. Notably, signaling striatum has been shown to play a critical role perception time. We hypothesize that patients PD perceive time differently accordance their specific clinical state. This means individual differences may be reflected timing behavior. To test this hypothesis, we recruited compared patients' state ability judge...
Abstract Impulse Control Disorder (ICD) in Parkinson’s disease is a behavioral addiction induced by dopaminergic therapies, but otherwise unclear etiology. The current study investigates the interaction of reward processing variables, therapy, and risky decision-making subjective feelings patients with versus without ICD. Patients (n = 18) 12) ICD performed task both ‘on’ ‘off’ standard-of-care therapies (the was on 2 different days order off visits randomized for each patient). During trial...
Abstract Dopaminergic signaling in the striatum has been shown to play a critical role perception of time. Decreasing striatal dopamine efficacy is at core Parkinson’s disease (PD) motor symptoms and changes dopaminergic action have associated with many comorbid non-motor PD. We hypothesize that patients PD perceive time differently accordance their specific clinical state. recruited compared individual differences patients’ features ability judge millisecond second intervals (500ms-1100ms)...
Abstract In the mammalian brain, midbrain dopamine neuron activity is hypothesized to encode reward prediction errors that promote learning and guide behavior by causing rapid changes in levels target brain regions. This hypothesis (and alternatives regarding dopamine’s role punishment-learning) has limited direct evidence humans. We report intracranial, sub-second measurements of release human striatum measured while volunteers (i.e., patients undergoing deep stimulation (DBS) surgery)...
Abstract Background Impulse Control Disorder (ICD) in Parkinson’s disease is a behavioral addiction arising secondary to dopaminergic therapies, most often dopamine receptor agonists. Prior research implicates changes striatal function and heightened activity the dorsal striatum of patients with ICD. However, this prior work does not possess temporal resolution required investigate signaling during real-time progression through various stages decision-making involving anticipation feedback....
Objective: To determine the utility of University Pennsylvania Smell Identification Test (UPSIT) in predicting Parkinson’s disease (PD) versus non-Parkinson’s (non-PD) final diagnosis by a movement disorder specialist Background: UPSIT is “scratch and sniff” smell test comprised 40 smells designed to detect hyposmia. Severe olfactory dysfunction common early symptom PD but not characteristic other parkinsonian syndromes, rendering potentially useful tool differentiation from non-PD...
Abstract Impulse Control Disorder (ICD) in Parkinson’s disease is a behavioral addiction induced by dopaminergic therapies, but otherwise unclear cognitive etiology. The current study investigates the influence of objective reward processing variables, therapy, and risky decision-making on ‘subjective feelings’ patients with versus without ICD. Patients (n = 18) 12) history ICD secondary to performed task (on off standard-of-care therapies). During task, participants choose ‘gamble’ or...
Abstract Introduction Currently, sub-second monitoring of neurotransmitter release in humans can only be performed during standard care invasive procedures like DBS electrode implantation. The procedure requires acute insertion a research probe and additional time surgery, which may increase infection risk. We sought to determine the impact our procedure, particularly extended on Methods screened 607 implantation at Wake Forest Baptist Medical Center between January 2011 through October 2020...