A5062274467- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
- Biochemical Analysis and Sensing Techniques
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neurobiology and Insect Physiology Research
- Multisensory perception and integration
- Neurological disorders and treatments
- Memory and Neural Mechanisms
- Urban Green Space and Health
- Cardiac Arrest and Resuscitation
- Epilepsy research and treatment
- Neural and Behavioral Psychology Studies
- Long-Term Effects of COVID-19
- Language, Metaphor, and Cognition
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Parkinson's Disease Mechanisms and Treatments
- Essential Oils and Antimicrobial Activity
- Urban Heat Island Mitigation
- Allergic Rhinitis and Sensitization
- Color perception and design
- Attention Deficit Hyperactivity Disorder
- Neuroscience and Neural Engineering
Abbott (United States)
2025
Karolinska Institutet
2018-2024
Stanford University
2022-2024
Stanford Medicine
2023-2024
Amirkabir University of Technology
2014
Abstract Although stress is an increasing global health problem in cities, urban green spaces can provide benefits. There is, however, a lack of understanding the link between physiological mechanisms and qualities spaces. Here, we compare effects visual stimuli (360 degree virtual photos environment, forest, park) to congruent olfactory (nature city odours) auditory (bird songs noise) on recovery. Participants (N = 154) were pseudo-randomised into participating one three environments...
In mammals respiratory-locked hippocampal rhythms are implicated in the scaffolding and transfer of information between sensory memory networks. These oscillations entrained by nasal respiration driven olfactory bulb. They then travel to piriform cortex where they propagate further downstream hippocampus modulate neural processes critical for formation. humans, bypassing airflow through mouth-breathing abolishes these impacts encoding as well recognition thereby reducing performance. It has...
Current non-invasive neuroimaging methods can assess neural activity in all areas of the human brain but olfactory bulb (OB). The OB has been suggested to fulfill a role comparable that V1 and thalamus visual system have closely linked wide range tasks neuropathologies. Here we present method for recording signals from with millisecond precision. We demonstrate obtained via recordings EEG electrodes at nasal bridge represent responses - term Electrobulbogram (EBG). EBG will aid future...
Abstract In response to the coronavirus disease 2019 (COVID-19) pandemic, countries have implemented various strategies reduce and slow spread of in general population. For that restrictions on its population a stepwise manner, monitoring COVID-19 prevalence is importance guide decision when impose new, or abolish old, restrictions. We are here determining whether measures odor intensity large sample can serve as one such measure. Online how intense common household odors perceived symptoms...
Attention deficit hyperactivity disorder (ADHD) is characterized by high distractibility and impaired executive functions. Notably, there mounting evidence suggesting that ADHD could be regarded as a default mode network (DMN) disorder. In particular, failure in regulating the dynamics of activity interactions DMN cognitive control networks have been hypothesized main source task interference causing attentional problems. On other hand, previous studies indicated pronounced fluctuations...
Significance Whether an odor's perceived valence induces approach response or triggers avoidance is critical for survival, and yet little known about the neural mechanisms supporting this decision. Using electrophysiological measures from human olfactory bulb (OB), first processing stage of system, full-body movement, we provide evidence that process initiated in OB. We demonstrate odor associated with both gamma beta activity Furthermore, show unpleasant odors have privileged temporal OB...
We recorded directly from the orbital (oPFC) and ventromedial (vmPFC) subregions of orbitofrontal cortex (OFC) in 22 (9 female, 13 male) epilepsy patients undergoing intracranial electroencephalography (iEEG) monitoring during an experimental task which participants judged accuracy self-referential autobiographical statements as well valenced self-judgments (SJs). found significantly increased high-frequency activity (HFA) ∼13% oPFC sites (10/18 subjects) 16% vmPFC (4/12 both these thought...
Recent advances in non-linear computational and dynamical modelling have opened up the possibility to parametrize dynamic neural mechanisms that drive complex behavior. Importantly, building models of neuronal processes is key importance fully understand disorders brain as it may provide a quantitative platform capable binding multiple neurophysiological phenotype profiles. In this study, we apply newly developed adaptive frequency-based model whole-brain oscillations resting-state fMRI data...
Neuronal oscillations route external and internal information across brain regions. In the olfactory system, two central nodes—the bulb (OB) piriform cortex (PC)—communicate with each other via neural to shape percept. Communication between these nodes have been well characterized in non-human animals but less is known about their role human system. Using a recently developed validated EEG-based method extract signals from OB PC sources, we show healthy participants that there bottom-up flow...
Abstract Removing function from a developed and functional sensory system is known to alter both cerebral morphology connections. To date, majority of studies assessing sensory-dependent plasticity have focused on effects either early onset or long-term loss little how the recent affects human brain. With aim determining connectivity, we assessed differences between individuals with acquired olfactory (duration 7–36 months) matched healthy controls in their grey matter volume, using...
Key to curtailing the COVID-19 pandemic are wide-scale screening strategies. An ideal screen is one that would not rely on transporting, distributing, and collecting physical specimens. Given olfactory impairment associated with COVID-19, we developed a perceptual measure of olfaction relies smelling household odorants rating them online.
Abstract Olfactory dysfunction is a prevalent non-motor symptom of Parkinson’s disease (PD). This result neurodegeneration within the olfactory bulb (OB), first processing area central system, and commonly precedes characteristic motor symptoms in PD by several years. Functional measurements OB could therefore potentially be used as an early biomarker for PD. Here, we non-invasive method, so-called electrobulbogram (EBG), to measure function age-matched healthy controls assess whether EBG...
Repetitive transcranial magnetic stimulation (rTMS) is a promising alternative therapy for treatment-resistant depression, although its limited remission rate indicates room improvement. As depression phenomenological construction, the biological heterogeneity within this syndrome needs to be considered improve existing therapies. Whole-brain modeling provides an integrative multi-modal framework capturing disease in holistic manner. Computational modelling combined with probabilistic...
The olfactory and endocrine systems have recently been shown to reciprocally shape the homeostatic processes of energy intake. As demonstrated in animal models, individual's metabolic state dynamically modulates how bulb process odor stimuli using a range signals. Here we aimed determine whether neural processing odors human is modulated by state. Participants were exposed food-associated odors, separate sessions being hungry sated, while responses from was obtained electrobulbogram. We...
Background: Olfactory dysfunction (OD) is a frequent symptom of Parkinson’s disease (PD) that appears years prior to diagnosis. Previous studies suggest PD-related OD different from non-parkinsonian forms olfactory (NPOD) as PD patients maintain trigeminal sensitivity opposed with NPOD who typically exhibit reduced sensitivity. We hypothesize the presence specific alteration functional connectivity between and processing areas in PD. Objective: aimed assess potential differences within...
Whether language is grounded in action and perception has been a key question cognitive science, yet little attention given to the sense of smell. We directly test whether smell necessary for comprehension odor language, by comparing processing group participants with no (anosmics) control participants. found evidence difference online taste between anosmics controls using lexical decision task semantic similarity judgment task, suggesting olfaction not critical language. Contrary...
ABSTRACT In response to the COVID-19 pandemic, countries have implemented various strategies reduce and slow spread of disease in general population. For that restrictions on its population a step-wise manner, monitoring prevalence is importance guide decision when impose new, or abolish old, restrictions. We are here determining whether measures odor intensity large sample can serve as one such measure. Online how intense common household odors perceived symptoms were collected from 2440...
Deep convolutional neural network (DCNN) provides a multivariate framework to detect relevant spatio-oscillatory patterns in the data beyond common mass-univariate statistics. Yet, its practical application is limited due low interpretability of results accuracy. We opted use DCNN with minimalistic architecture design and large penalized terms yield generalizable clinically model. Our was trained based on scalp topology electroencephalography (EEG) from an open access dataset, constituting...
Preparatory brain activity is a cornerstone of proactive cognitive control, top-down process optimizing attention, perception, and inhibition, fostering flexibility adaptive attention control in the human brain. In this study, we proposed neuroimaging-informed convolutional neural network model to predict performance from baseline pre-stimulus preparatory electrophysiological core regions. Particularly, combined with perturbation-based occlusion sensitivity analysis, pinpointed regions most...
A core function of the olfactory system is to determine valence odors. In humans, central processing odor perception has been shown take form already within bulb (OB), but neural mechanisms by which this important information communicated to, and from, cortex (piriform cortex, PC) are not known. To assess communication between 2 nodes, we simultaneously measured odor-dependent activity in OB PC from human participants while obtaining trial-by-trial ratings. By doing so, could when subjective...
Detection of early and reliable symptoms is important in relation to limiting the spread an infectious disease. For COVID-19, most specific symptom either losing or experiencing reduced olfactory functions. Anecdotal evidence suggests that dysfunction also one earlier but objective measures supporting this notion are currently missing. To determine whether loss sign we assessed available longitudinal data from a web-based interface enabling individuals test their sense smell by rating...
The use of oral contraceptives (OC) in the form a hormonal pill has been widespread for decades. Despite its popularity and long-time use, there is still much ambiguity anecdotal reports about range potential side effects. Here, we addressed effect OC on chemosensory perception. Previous research almost exclusively focused olfaction, but expanded this to trigeminal system sense taste. We used Bayesian statistics compare olfactory, trigeminal, taste detection abilities between group 34 normal...
The prevalence of smell loss in Parkinson's Disease (PD) patients greatly exceeds that the characteristic motor symptoms defining disease by several years. One hypothesis cause PD states it is initiated olfactory bulb — critical first central processing stage system and nerve might serve as an entry point to OB for pathogens or environmental components. But what if there was no start with? Recent data demonstrate cortical, but not peripheral, blindness acts a protective factor against...