A5036319562- Nuclear physics research studies
- Functional Brain Connectivity Studies
- Nuclear Physics and Applications
- Transcranial Magnetic Stimulation Studies
- Atomic and Molecular Physics
- Memory and Neural Mechanisms
- Black Holes and Theoretical Physics
- Stochastic processes and financial applications
- Advanced Chemical Physics Studies
- Treatment of Major Depression
- Heart Rate Variability and Autonomic Control
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- X-ray Spectroscopy and Fluorescence Analysis
- Monoclonal and Polyclonal Antibodies Research
- Neural and Behavioral Psychology Studies
- Numerical methods for differential equations
- Alzheimer's disease research and treatments
- Optical Imaging and Spectroscopy Techniques
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Advanced NMR Techniques and Applications
- Advanced Numerical Methods in Computational Mathematics
- Nuclear reactor physics and engineering
- Phosphodiesterase function and regulation
Uppsala University
2014-2025
Science for Life Laboratory
2023-2025
Karolinska Institutet
2024-2025
Karolinska University Hospital
2025
KTH Royal Institute of Technology
1992-2024
Örebro University
2024
Stockholm University
2024
Uppsala University Hospital
2020-2023
Vattenfall (Sweden)
2021
Karlstad University
2019
The apolipoprotein E «4 (APOE «4) is the main known genetic risk factor for Alzheimer's disease.Genetic assessments in combination with other diagnostic tools, such as neuroimaging, have potential to facilitate early diagnosis.In this large-scale functional MRI (fMRI) study, we contrasted 30 APOE carriers (age range: 49-74 years; 19 females), of which 10 were homozygous allele, and non-carriers regard brain activity during a semantic categorization task.Test groups closely matched sex, age...
The aim of the BENCHOP project is to provide finance community with a common suite benchmark problems for option pricing. We detailed description six together methods compute reference solutions. have implemented fifteen different numerical these problems, and compare their relative performance. All implementations are available on line can be used future development comparisons.
Resting-state functional magnetic resonance imaging (fMRI) can assess modulation of connectivity networks following repetitive transcranial stimulation (rTMS) in the treatment depression. Functional near-infrared spectroscopy (fNIRS) is well suited for concurrent application during rTMS sessions to capture immediate blood oxygenation (oxy-Hb) effects, however limited spatial resolution. To understand network effects behind such a prefrontal fNIRS response rTMS, and test whether signal may be...
Intermittent theta burst stimulation (iTBS) over the dorsomedial prefrontal cortex (DMPFC) has shown promise in open-label trials of depression.In this randomized, double-blind, sham controlled trial we evaluate iTBS DMPFC for anhedonia, avolition, and blunted affect patients with schizophrenia or depression. Active was delivered 1200 pulses per session, twice daily ten weekdays at target intensity an angled figure-of eight coil. Sham condition comprised magnetically shielded side coil...
Non-invasive assessment of fibrogenic activity, rather than fibrotic scars, could significantly improve the management diseases and development anti-fibrotic drugs. This study explores potential an Affibody molecule (Z09591) labeled with Al(18)F-restrained complexing agent (RESCA) method as a tracer for non-invasive detection cells. Z09591 was functionalized RESCA chelator direct labeling [
Episodic memory for simple commands is better following enacted than verbal encoding. This has been proposed to be due the possibility base retrieval on motor information. Here we used PET test hypothesis that brain areas show increased retrieval-related activity compared Brain was also monitored during after imaginary enactment It found in right cortex maximal encoding enactment, intermediate and lowest These findings provide support one basis facilitating effect performance of overt, a...
fMRI studies have identified distinct resting-state functional connectivity (RSFC) networks associated with the anterior and posterior hippocampus. However, relevance of these two is still largely unknown. Hippocampal lesion task-related point to a role for hippocampus in nonspatial episodic memory spatial memory. We used Relevance Vector Regression (RVR), machine-learning method that enables predictions continuous outcome measures from multivariate patterns brain imaging data, test...
Excited states in 98Cd, two proton holes from 100Sn, were identified and studied for the first time, using in-beam spectroscopy with highly selective ancillary detectors. The structure of (πg9/2)−2 two-proton-hole spectrum below a T1/2=0.48(16)μs isomer is deduced compared to shell-model predictions. A tentative Iπ=(8+) assignment, as suggested by systematics, yields strongly reduced B(E2,8+→6+)=0.44(−10+20)W.u., corresponding an effective charge eπ=0.85(−10+20)e, which at variance existing...
The structure of 105Sn has been investigated through the 50Cr(58Ni,2pn) reaction at a beam energy 210 MeV. In addition to an extension spherical level scheme regular sequence dipole transitions found. states band are suggested be built on neutron h11/22 excitation coupled proton particle-hole states, which polarize core slightly prolate shape. experimental results in agreement with prediction tilted axis cranking calculations, satisfactorily explain properties band.Received 3 July...
The hippocampus (HC) interacts with distributed brain regions to support memory and shows significant volume reductions in aging, but little is known about age effects on hippocampal whole-brain structural covariance. It also unclear whether the anterior posterior HC show similar or distinct patterns of covariance what extent these are related functions organized along longitudinal axis. Using multivariate approach partial least squares, we assessed addition regional volume, young,...
Social considerations for a sustainable future lead to market demands electromobility. Hence, electrical power distribution operators are concerned about the real ongoing problem of electrification transport sector. In this regard, paper aims investigate large-scale integration electric vehicles in Swedish network. To end, pattern is taken into consideration as appears literature other countries and applies culture. Moreover, different charging levels including smart techniques examined...
Platelet-derived growth factor receptor beta (PDGFRβ) is a overexpressed on activated hepatic stellate cells (aHSCs). Positron emission tomography (PET) imaging of PDGFRβ could potentially allow the quantification fibrogenesis in fibrotic livers. This study aims to evaluate fluorine-18 radiolabeled Affibody molecule ([18F]TZ-Z09591) as PET tracer for liver fibrogenesis.In vitro specificity studies demonstrated that trans-Cyclooctenes (TCO) conjugated Z09591 had picomolar affinity human...
Abstract Gamma-aminobutyric acid (GABA) and glutamate are implicated in the antidepressant effects of repetitive transcranial magnetic stimulation (rTMS), though findings from resonance spectroscopy (MRS) inconsistent. Furthermore, relationship between GABA A -receptor availability rTMS outcomes remains largely unexplored. In this study, levels dorsal anterior cingulate cortex (dACC) were measured using a 1 H-MRS MEGA-PRESS sequence 42 patients with bipolar or unipolar depression, both...
<title>Abstract</title> Background Gamma-aminobutyric acid (GABA) dysfunction has been implicated in depression, although research findings remain inconsistent. This may indicate that distinct biological mechanisms underlie different symptom profiles depressive episodes. GABA deficiency might be especially relevant cases characterised by psychomotor retardation and vegetative symptoms, which are prominent melancholia. study aimed to investigate if such melancholic features related levels or...
Abstract The enzyme phosphodiesterase 10A (PDE10A) is abundant in striatal medium spiny neurons and has been implicated the pathophysiology of schizophrenia animal models investigated as a possible new pharmacological treatment target. A reduction prefrontal cortical thickness common schizophrenia, but how this relates to PDE10A expression unknown. Our study aim was compare, we believe for first time, non-displaceable binding potential (BP ND ) validated ligand [ 11 C]Lu AE92686 between...