A5045375388- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Transcranial Magnetic Stimulation Studies
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Stress Responses and Cortisol
- Neurological Complications and Syndromes
- Diet and metabolism studies
- Motor Control and Adaptation
Uppsala University
2019-2025
Intermittent theta burst stimulation (iTBS) over the dorsomedial prefrontal cortex (DMPFC) has shown promise in open-label trials of depression.In this randomized, double-blind, sham controlled trial we evaluate iTBS DMPFC for anhedonia, avolition, and blunted affect patients with schizophrenia or depression. Active was delivered 1200 pulses per session, twice daily ten weekdays at target intensity an angled figure-of eight coil. Sham condition comprised magnetically shielded side coil...
<title>Abstract</title> Background Gamma-aminobutyric acid (GABA) dysfunction has been implicated in depression, although research findings remain inconsistent. This may indicate that distinct biological mechanisms underlie different symptom profiles depressive episodes. GABA deficiency might be especially relevant cases characterised by psychomotor retardation and vegetative symptoms, which are prominent melancholia. study aimed to investigate if such melancholic features related levels or...
Response rates after and tolerability of electroconvulsive therapy (ECT) in depressive disorders with psychiatric comorbidity are uncertain. Data on patients a episode first course ECT were collected from the Swedish National Quality Register for ECT. Logistic regression analyses, adjusted gender, age, severity, used to compare without comorbidity. The clinical response assessment Clinical Global Impression - Improvement Scale was 4413 memory item Comprehensive Psychiatric Rating subjective...
Electroconvulsive therapy (ECT) is an important treatment for several severe psychiatric conditions, yet its precise mechanism of action remains unknown. Increased inhibition in the brain after ECT seizures, mediated by γ-aminobutyric acid (GABA), has been linked to clinical effectiveness. Case series on epileptic patients report a postictal serum concentration increase GABA
Gamma-aminobutyric acid (GABA) deficiency is suggested in depressive disorders, along with alterations cortical excitability. However, whether these excitability changes are related to GABAA receptor availability largely unknown. Our aim was assess the correlation between measures depressed patients and healthy controls. Twenty-eight a major episode, measured before after participating clinical trial repetitive transcranial magnetic stimulation (TMS), 15 controls underwent [11C]flumazenil...
<title>Abstract</title> Background Electroconvulsive therapy (ECT) is an important treatment for several severe psychiatric conditions, yet its precise mechanism of action remains unknown. Increased inhibition in the brain after ECT seizures, mediated by γ-aminobutyric acid (GABA), has been linked to clinical effectiveness. Case series on epileptic patients report a postictal serum concentration increase GABA<sub>A</sub> receptor agonist allopregnanolone. Serum allopregnanolone unchanged...
Physiological parameters that predict electroconvulsive therapy (ECT) effectiveness may reflect propagation of the induced epileptic seizure. As an indication seizure to diencephalon, we here examined correlation between prolactin increase after ECT and clinical evaluation parameters, focusing on peak heart rate. a proxy for peripheral endocrine stress response, postictal cortisol increase.Participants were consecutively recruited from patients (n = 131, age 18-85 years). The first session...
Catatonia is a severe psychiatric syndrome that includes psychological and motor symptoms can occur during the whole life span. Yet well known, prevalence estimates of catatonia are uncertain, ...