A5056964722- Radiation Therapy and Dosimetry
- Radiation Detection and Scintillator Technologies
- Advanced Radiotherapy Techniques
- Nuclear Physics and Applications
- Radiation Effects and Dosimetry
- Particle Detector Development and Performance
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Gamma-ray bursts and supernovae
- Optical measurement and interference techniques
- Structural Health Monitoring Techniques
- Head and Neck Cancer Studies
- Ocular Oncology and Treatments
- CCD and CMOS Imaging Sensors
- Atomic and Subatomic Physics Research
- Advanced Measurement and Detection Methods
- Bone Tumor Diagnosis and Treatments
- Brain Metastases and Treatment
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Astronomy and Astrophysical Research
- Glioma Diagnosis and Treatment
- Photodynamic Therapy Research Studies
The University of Texas MD Anderson Cancer Center
2015-2025
The University of Texas Health Science Center at Houston
2019-2020
University of Houston
2015-2018
Purdue University West Lafayette
2013-2015
Background/Objectives: Stereotactic body radiation therapy (SBRT) for skull base reirradiation is particularly challenging, as patients have already received substantial doses to the region, and nearby normal organs may approached their tolerance limit from prior treatments. In this study, we reviewed characteristics capabilities of four advanced external beam delivery systems modern treatment planning evaluated plan quality each technique using patient cases. Methods: SBRT plans were...
The objective of this study is to establish the feasibility using radiation-induced acoustics measure range and Bragg peak dose from a pulsed proton beam. Simulation studies implementing prototype scanner design based on computed tomographic methods were performed investigate sensitivity integral dose.Derived thermodynamic wave equation, pressure signals generated deposited beam with 1 cm lateral width 16, 20, 27 in water Monte Carlo simulated. resulting dosimetric images reconstructed 3D...
Purpose Currently, no detectors are capable of simultaneously measuring dose and linear energy transfer ( LET ) in real time. In this study, we evaluated the feasibility exploiting difference response various organic plastic scintillation to measure therapeutic proton beams. The hypothesis behind work was that ratio responses different scintillators exposed same beam can be used obtain a vs calibration curve then infer under any other measurement conditions. Methods We first similar with...
Existing systems for proton beam dosimetry are limited in their ability to provide a complete, accurate, and detailed account of volumetric dose distribution. In this work, we describe the design development portable, fast, reusable liquid scintillator-based three-dimensional (3D) optical detection system use therapy. Our long-term goal is clinically characterization, dosimetry, quality assurance studies discrete spot scanning systems. The used 20 × cm3 scintillator volume. Three mutually...
With the expansion of proton radiotherapy for cancer treatments, it has become important to explore proton-based imaging technologies increase accuracy treatment planning, alignment, and verification. The purpose this study is demonstrate feasibility using a volumetric liquid scintillator generate radiographs at clinically relevant energy (180 MeV) an integrating detector approach. capable capturing wide distribution residual beam energies from single irradiation. It potential reduce...
Accurate confirmation and verification of the range spot scanning proton beams is crucial for correct dose delivery. Current methods to measure beam using ionization chambers are either time-consuming or result in measurements with poor spatial resolution. The large-volume liquid scintillator detector allows real-time entire profile a beam. Thus, detectors an ideal tool measuring commissioning quality assurance. However, optical artefacts may decrease accuracy within tank. purpose current...
The purpose of this study is to compare the image quality an integrating proton radiography (PR) system, composed a monolithic scintillator and two digital cameras, using integral lateral-dose depth-dose reconstruction techniques. Monte Carlo simulations were used obtain energy deposition in 3D detector (30 × 30 cm3poly vinyl toluene organic scintillator) create radiographs various phantoms-a slanted aluminum cube for spatial resolution analysis Las Vegas phantom contrast analysis. light...
The ionization quenching phenomenon in scintillators must be corrected to obtain accurate dosimetry particle therapy. purpose of this study was develop a methodology for correcting camera projection measurements 3D scintillator detector exposed proton pencil beams. Birks' model and the energy deposition by secondary electrons (EDSE) were used correct light captured prototype detector. made 20 cm × tank filled with liquid scintillator, three cameras. four proton-beam energies (84.6, 100.9,...
Purpose: The objectives of this study are to simulate the ionizing radiation induced thermoacoustic signal from scanning proton beam; and investigate various designs techniques ultrasound tomographic imaging map three dimensional dose (3D) distributions. Methods: A 3D fluence distribution in a water phantom spot beam treatment nozzle was simulated using Monte Carlo (MC) code FLUKA (v. 2012) for 6.5, 16 27 cm range. An initial radio‐acoustic computed (RCT) scanner design cylinder with 128...
Purpose: Investigate the design aspects and imaging dose capabilities of Radiation Acoustics Computed Tomography (RA CT) dosimeter for Proton induced acoustics, with objective to characterize a pulsed pencil proton beam. The focus includes scanner geometry, transducer array, bandwidth on image quality. Methods: geometry is cylindrical water phantom (length 40cm, radius 15cm) 71 ultrasound transducers placed along length end cylinder achieve weighted set projections spherical sampling. A 3D...
Purpose: The purpose of this work is to develop a geometric calibration method accurately calculate physical distances within liquid scintillator detector and assess the accuracy, consistency, robustness proton beam range measurements when using system with proposed process. Methods: We developed procedure convert pixel locations in camera frame into frame. To ensure was performed before each experiment. irradiated spot scanning beams 94 energies two deliveries. A CCD used capture...
Purpose: The purpose of this project is to build a volumetric scintillation detector for quantitative imaging 3D dose distributions proton beams accurately in near real‐time. Methods: liquid scintillator (LS) consists transparent acrylic tank (20×20×20 cm 3 ) filled with that when irradiated protons generates light. To track rapid spatial and variations spot scanning we used three scientific‐complementary metal‐oxide semiconductor (sCMOS) imagers (2560×2160 pixels). cameras collect optical...
Purpose: To evaluate the accuracy and usefulness of plastic scintillation detectors used for skin dosimetry patients undergoing passive scatter proton therapy. Methods: Following an IRB approved protocol, six passively scattered beam therapy prostate cancer were selected in vivo using Exradin W1 scintillator. The detector was calibrated on a Cobalt‐60 unit, phantom measurements with parallel plate ion chamber to account under‐response due high LET at energies treatment. Measurements made...
Proton therapy offers dosimetric advantage over conventional photon due to the finite range of proton beam, which improves dose conformity. However, one main challenges beam is verification complex treatment plans delivered a patient. Thus, 3D measurements are needed verify distribution. A organic scintillator detector capable such measurements. scintillators exhibit non-linear relation ionization density called quenching. The quenching phenomenon in must be accounted for obtain accurate We...
Purpose: Our (long‐term) objective is to develop a US manipulator that will provide in situ radiation response and image‐guided therapy for bladder cancer based on photoacoustic molecular imaging. Methods: A platform was devised reproducible positional frame of reference targeting anatomic structure between MDCT scans, lieu CBCT, fuse scans are taken patient while the CT scanner IRMT. Through co‐registration, anatomical positions, we identified common coordinate system be used Eclipse....
________________________________________________________________________________1.371 for the 6MV beams, TrueBeam and Versa HD, respectively.The same figure 10MV beams were 1.484-1.524,and 1.501-1.543.Concerning beam penetration, TPR20,10 6 10 flattened FFF were: 0.665, 0.629 (6MV) 0.738, 0.703 (10MV), while HD are: 0.684, 0.678 0.734, 0.721 (10MV). Conclusion:Renormalization factor unflatness parameters proved to be efficient describe characteristics.Renormalization factors here presented...