The role of estrogen in the regulation inflammatory response is not well defined. In this study, we investigated effects ovarian hormones on acute mouse lungs. Acute lung injury was induced by intratracheal instillation bacterial lipopolysaccharide (LPS) male, female, and ovariectomized (OVX) mice. End points were polymorphonuclear neutrophil (PMN) content bronchoalveolar lavage (BAL) fluids, myeloperoxidase activity whole lung, leak albumin into lung. After LPS, all end substantially...

Pseudoprogression is a clinical and imaging phenomenon characterized by an increase in the size contrast enhancement pattern of glioma lesion following treatment with radiotherapy. In human beings, substantial body literature describes pseudoprogression glioblastoma after The occurrence gliomas cranial nerves has been reported beings as clinically rare entity. A 7-year-old spayed female French Bulldog was presented left-sided craniofacial muscle atrophy for duration 3 months episodes...

Abstract Case Description —A 9-year-old spayed female mixed-breed dog was evaluated because of a progressively worsening, nonproductive cough and gagging 1 year's duration. Clinical Findings —Physical examination results were unremarkable. A cranial mediastinal mass identified at the heart base with 3-view thoracic radiography. CT scan thorax revealed an invasive surrounding major vessels that not considered surgically resectable. Thoracoscopic biopsy specimens obtained, histologic...

We envision that CaWO4 (CWO) nanocrystals have the potential for use in biomedical imaging and therapy because of unique ways this material interacts with high-energy radiation. These applications, however, require development nanoparticle (NP) formulations are suitable vivo applications; primarily, formulated nanoparticles should be sufficiently small, chemically biologically inert, stable against aggregation under physiological conditions. The present study demonstrates one such method...

The lung inflammatory response caused by intratracheal deposition of IgG immune complexes (IC) includes the production IL-6, which signals through activation STAT transcription factors. Recently, suppressor cytokine signaling 3 (SOCS3) has been shown to be a key negative regulator IL-6/gp130/Jak/STAT3 signal transduction. Although SOCS3 implicated in several diseases, very little is known regarding its and function during acute inflammation. Our previous study showed that IL-6/STAT3 was...

Abstract Background Gastric wall edema has not been reported as a complication of acute pancreatitis in dogs. Objective To describe the ultrasonographic features gastric thickening dogs with pancreatitis. Animals Fourteen evidence and clinical diagnosis pancreatitis, increased thickness (>5 mm). Methods A retrospective search medical records from 2014 to 2016 was performed identify that had were diagnosed clinically. The changes such thickness, layering appearance, echogenicity,...

Radiation therapy is a primary treatment modality for many forms of cancer. Normally, the highest tolerable dose ionizing radiation used to treat tumors, but limitations imposed by normal tissue complications present challenges local tumor control. In light this, class compounds called radio-sensitizers have been developed enhance effectiveness radiation. Many these are small molecule drugs found interact favorably with therapy, recent advances made using nanoparticles as radio-sensitizers....

Abstract An English Bulldog underwent radiation therapy of an intracranial, left lateral ventricle mass. Following resolution the primary mass, intraventricular fourth lesion developed. Subsequently, multiple lesions developed from cervical central canal and leptomeninges. Serial magnetic resonance imaging documented propagation along cerebrospinal fluid (CSF) pathways, known as “CSF drop metastasis.” Histopathology confirmed multifocal leptomeningeal oligodendroglioma. Oligodendroglioma...

Abstract Since 2010, there has been little published data on the state of equipment and infrastructure in veterinary radiation oncology clinical practice. These are important not only to identify status use technology within community but also help extent medical physics support. The purpose our study is report findings from a survey oncologists USA, Canada, select centers outside North America 2022. A 40‐question covering topics such as type radiotherapy equipment, techniques offered,...

Abstract Stereotactic radiotherapy is a highly conformal treatment option for intracranial and extracranial malignancies. utilizes specialized equipment specifically designed to avoid normal tissue while delivering ablative treatments with submillimeter precision accuracy. Linear accelerator based stereotactic incorporates on‐board image guidance utilizing cone beam computed tomography (CT). Many institutions lack the ability provide CT but delivery of accuracy still feasible. The purpose...

Abstract A 10‐year‐old female spayed boxer was treated with stereotactic radiotherapy (SRT) for a suspected glioma in the left piriform lobe. The intra‐axial lesion T2 hyperintense, FLAIR T1 hypointense, and did not uptake contrast. Imaging performed an MRI every 3 months, at 6‐month recheck, new lesions hippocampus right lobe were evident without clinically apparent neurological progression. second course of SRT prescribed lesions. Euthanasia elected 14 months after first SRT, necropsy...

A 5-year-old spayed female Shih Tzu was referred for evaluation of a nasal transitional carcinoma. total lifetime dose 117 Gy delivered to the intranasal mass in three courses over nearly 2 years using fractionated intensity modulated radiation therapy (IMRT) spare normal tissues. Clinically significant late tissue side effects were limited bilaterally diminished tear production. The patient died metastatic disease progression 694 days after completion course 1. This case demonstrates that...

The goal of this study was to design a positioning device that would allow for selective irradiation the mouse brain with clinical linear accelerator.We designed and fabricated an immobilization fixture incorporates three functions: head stabilizer (through ear bars tooth bar), gaseous anesthesia delivery scavenging, tissue mimic/bolus. Cohorts five mice were irradiated such each in cohort received unique dose between 1000 3000 cGy. DNA damage immunohistochemistry used validate increase...

In radiation therapy (RT) treatment planning for canine head and neck cancer, the tonsils may be included as part of treated volume. Delineation on computed tomography (CT) scans is difficult. Error or uncertainty in volume location contoured structures result failure. The purpose this prospective, observer agreement study was to assess interobserver tonsillar contouring by two groups trained observers. Thirty dogs undergoing pre- post-contrast CT studies were included. After postcontrast...

Abstract There is a lack of information regarding interobserver agreement on canine meningioma gross tumor volume (GTV) delineation, and the impact MRI this agreement. The objectives retrospective, secondary analysis, observer study were to describe between veterinary radiation oncologists GTV for intracranial meningioma, compare delineation based CT alone fused CT‐MRI. Eighteen delineated 13 dogs with an imaging diagnosis pre‐ postcontrast CT, T1‐weighted magnetic resonance, T2‐weighted...

Radiotherapy (RT) for lung or liver tumors can be challenging due to respiration-induced organ motion (RIOM). There are some methodological solutions minimize RIOM. We explored a new approach evaluate the feasibility and reproducibility of RIOM during RT with five total client-owned tumor-bearing animals using remote-triggered breath-hold ventilator under general anesthesia image acquisition RT. was one stereotactic body radiotherapy, conventionally fractionated definitive intent, three...

Case series summary Urinary bladder masses in four cats were treated with palliative radiation therapy (RT). Three previously diagnosed chronic kidney disease (CKD): International Renal Interest Society (IRIS) stage 2 two and IRIS 3 one cat. One cat had a diagnosis of hyperthyroidism inflammatory bowel disease. urinary tract infections by urine culture susceptibility testing prior to or during treatment. All patients cytospin cytology performed; case showed suspect urothelial carcinoma three...

Purpose: Our (long‐term) objective is to develop a US manipulator that will provide in situ radiation response and image‐guided therapy for bladder cancer based on photoacoustic molecular imaging. Methods: A platform was devised reproducible positional frame of reference targeting anatomic structure between MDCT scans, lieu CBCT, fuse scans are taken patient while the CT scanner IRMT. Through co‐registration, anatomical positions, we identified common coordinate system be used Eclipse....

Purpose: Ultrasound (US) is a noninvasive, nonradiographic imaging technique with high spatial and temporal resolution that can be used for localizing soft‐tissue structures tumors in real‐time during radiotherapy (inter‐ intra‐fraction). A detailed methodology integrating 3D‐US within RT presented. This method easier to adopt into current treatment protocol than US based systems reduces user variability image acquisition, thus eliminating transducer induced changes limit CT planning system....