A5015789479- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Melanoma and MAPK Pathways
- Infective Endocarditis Diagnosis and Management
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- T-cell and B-cell Immunology
- Forest Insect Ecology and Management
- Plant tissue culture and regeneration
- Coronary Artery Anomalies
- Venous Thromboembolism Diagnosis and Management
- Myasthenia Gravis and Thymoma
- COVID-19 Clinical Research Studies
- Medical Imaging and Pathology Studies
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Issues in Pregnancy
- SARS-CoV-2 and COVID-19 Research
- Plant Pathogens and Fungal Diseases
- Kawasaki Disease and Coronary Complications
- Pituitary Gland Disorders and Treatments
- Histone Deacetylase Inhibitors Research
- IoT-based Smart Home Systems
Paras Hospitals
2025
Oncode Institute
2020-2023
The Netherlands Cancer Institute
2020-2023
Dutch Cancer Society
2020-2022
University of Pavia
2021
Indian Institute of Technology Dhanbad
2021
National Institute for Interdisciplinary Science and Technology
2021
Baruch S. Blumberg Institute
2021
National Institute of Medical Statistics
2016
Nizam's Institute of Medical Sciences
2015
Neoadjuvant ipilimumab + nivolumab has demonstrated high pathologic response rates in stage III melanoma. Patients with low intra-tumoral interferon-γ (IFN-γ) signatures are less likely to benefit. We show that domatinostat (a class I histone deacetylase inhibitor) addition anti-PD-1 anti-CTLA-4 increased the IFN-γ and reduced tumor growth our murine melanoma model, rationalizing evaluation patients. To stratify patients into cohorts, we developed a baseline signature expression algorithm,...
Bhatter, Pallav; Gupta, Vipul; Kumar, Rao, Dusa Srinivas; Agarwal, Ujjwal; Parthasarathy, Rajsrinivas Author Information
Continuous combination of MAPK pathway inhibition (MAPKi) and anti-programmed death-(ligand) 1 (PD-(L)1) showed high response rates, but only limited improvement in progression-free survival (PFS) at the cost a frequency treatment-related adverse events (TRAE) patients with BRAFV600-mutated melanoma. Short-term MAPKi induces T-cell infiltration is synergistic death-1 (PD-1) preclinical melanoma mouse model. The aim this phase 2b trial was to identify an optimal regimen short-term dabrafenib...
Glucose limitation and increased lactic acid levels are consequences of the elevated glycolytic activity tumor cells, constitute a metabolic barrier for function infiltrating effector immune cells. The immune-suppressive functions regulatory T cells (Tregs) unobstructed in lactic-acid rich environments. However, impact on induction Tregs remains unknown. We observed TGFβ-mediated Forkhead box P3+ (FoxP3+ ) presence extracellular acid, glycolysis-independent, acidity-dependent manner. These...
Abstract Cross-presentation of tumor antigens by dendritic cells (DC) is crucial to prime, stimulate and restimulate CD8+ T cells. This process important in initiating maintaining an antitumor response. Here, we show that the presence conventional type 1 DCs (cDC1), a DC subtype excels cross-presentation, correlated with response neoadjuvant immune checkpoint blockade (ICB) melanoma. led us hypothesize patients failing respond ICB could benefit from enhanced cross-presentation antigens. We...
TPS10087 Background: Previous OpACIN and OpACIN-neo studies, investigating neoadjuvant ipilimumab (IPI) plus nivolumab (NIVO), demonstrated high pathologic response rates (74-78%) favorable long-term outcomes in patients (pts) achieving response; at 36 18 months follow-up, respectively, only 1/71 (1.4%) pts with has relapsed. In contrast, without (pNR) have a poor prognosis; 15/23 (65.2%) relapsed so far. This emphasizes the need for baseline biomarkers predictive of non-response new...
While immunotherapy has become standard-of-care for cutaneous melanoma patients, primary and acquired resistance prevent long-term benefits about half of the late-stage patients. Pre-clinical models are essential to increase our understanding mechanisms melanomas, aiming improve efficacy immunotherapy. Here, we present two novel syngeneic transplantable murine cell lines derived from same tumor induced on BrafV600E Pten−/− mice: MeVa2.1 MeVa2.2. Derivatives these expressing foreign antigen...
Abstract Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) has been responsible for the largest pandemic in recent decades. After seemingly being control due to consequent lock-downs and social distancing, majority of countries faces currently a second wave exponentially increasing infections, hospital referrals deaths SARS-CoV-2-mediated disease (COVID-19). To date, no effective vaccination found, wearing masks distancing are only approaches reduce further spreading. However,...
<h3>Background</h3> The previous OpACIN and OpACIN-neo studies investigating neoadjuvant IPI plus NIVO have demonstrated high pathologic response rates (74–78%) favorable long-term outcomes for patients (pts) with a pathological response; at 36 18 months follow up only 1/71 (1.4%) responders has relapsed. In contrast, non-responders poor prognosis; 15/23 (65.2%) relapsed so far. This emphasizes the need baseline biomarkers predictive of non-response new treatment combinations these pts. our...
Objectives:We sought to determine the prognostic use of inotropic contractile reserve on risk stratification and prognostication women with peripartum cardiomyopathy.Background: Peripartum cardiomyopathy is a rare disorder effecting in their prime years life.There appears be an initial high-risk period 25% 50% dying within first 3 months postpartum.Early are, thus, crucial.However, only limited data are available.Methods: In all, 10 (mean age 20.7 years) severe left ventricular (LV)...
Abstract Cushing syndrome (CS) is the result of extended exposure to excessive glucocorticoids from endogenous or exogenous sources. Cushing's associated with reduced life quality and increased mortality, mostly due cardiovascular disease. We report case a 26-year-old female patient who presented heart failure was found have recovered after supportive treatment.
<p>Supplementary Data file, Figure S1-S9, Table S1</p>
<div>Abstract<p>Cross-presentation of tumor antigens by dendritic cells (DC) is crucial to prime, stimulate and restimulate CD8<sup>+</sup> T cells. This process important in initiating maintaining an antitumor response. Here, we show that the presence conventional type 1 DCs (cDC1), a DC subtype excels cross-presentation, correlated with response neoadjuvant immune checkpoint blockade (ICB) melanoma. led us hypothesize patients failing respond ICB could benefit from...
<p>Supplementary Data file, Figure S1-S9, Table S1</p>
<div>Abstract<p>Cross-presentation of tumor antigens by dendritic cells (DC) is crucial to prime, stimulate and restimulate CD8<sup>+</sup> T cells. This process important in initiating maintaining an antitumor response. Here, we show that the presence conventional type 1 DCs (cDC1), a DC subtype excels cross-presentation, correlated with response neoadjuvant immune checkpoint blockade (ICB) melanoma. led us hypothesize patients failing respond ICB could benefit from...
<p>Supplementary Data file, Figure S1-S9, Table S1</p>
<div>Abstract<p>Cross-presentation of tumor antigens by dendritic cells (DC) is crucial to prime, stimulate and restimulate CD8<sup>+</sup> T cells. This process important in initiating maintaining an antitumor response. Here, we show that the presence conventional type 1 DCs (cDC1), a DC subtype excels cross-presentation, correlated with response neoadjuvant immune checkpoint blockade (ICB) melanoma. led us hypothesize patients failing respond ICB could benefit from...
<p>Supplementary Data file, Figure S1-S9, Table S1</p>