A5021740246- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- T-cell and B-cell Immunology
Oncode Institute
2023
The Netherlands Cancer Institute
2023
Glucose limitation and increased lactic acid levels are consequences of the elevated glycolytic activity tumor cells, constitute a metabolic barrier for function infiltrating effector immune cells. The immune-suppressive functions regulatory T cells (Tregs) unobstructed in lactic-acid rich environments. However, impact on induction Tregs remains unknown. We observed TGFβ-mediated Forkhead box P3+ (FoxP3+ ) presence extracellular acid, glycolysis-independent, acidity-dependent manner. These...
Abstract Cross-presentation of tumor antigens by dendritic cells (DC) is crucial to prime, stimulate and restimulate CD8+ T cells. This process important in initiating maintaining an antitumor response. Here, we show that the presence conventional type 1 DCs (cDC1), a DC subtype excels cross-presentation, correlated with response neoadjuvant immune checkpoint blockade (ICB) melanoma. led us hypothesize patients failing respond ICB could benefit from enhanced cross-presentation antigens. We...
<p>Supplementary Data file, Figure S1-S9, Table S1</p>
<div>Abstract<p>Cross-presentation of tumor antigens by dendritic cells (DC) is crucial to prime, stimulate and restimulate CD8<sup>+</sup> T cells. This process important in initiating maintaining an antitumor response. Here, we show that the presence conventional type 1 DCs (cDC1), a DC subtype excels cross-presentation, correlated with response neoadjuvant immune checkpoint blockade (ICB) melanoma. led us hypothesize patients failing respond ICB could benefit from...
<p>Supplementary Data file, Figure S1-S9, Table S1</p>
<div>Abstract<p>Cross-presentation of tumor antigens by dendritic cells (DC) is crucial to prime, stimulate and restimulate CD8<sup>+</sup> T cells. This process important in initiating maintaining an antitumor response. Here, we show that the presence conventional type 1 DCs (cDC1), a DC subtype excels cross-presentation, correlated with response neoadjuvant immune checkpoint blockade (ICB) melanoma. led us hypothesize patients failing respond ICB could benefit from...
<p>Supplementary Data file, Figure S1-S9, Table S1</p>
<div>Abstract<p>Cross-presentation of tumor antigens by dendritic cells (DC) is crucial to prime, stimulate and restimulate CD8<sup>+</sup> T cells. This process important in initiating maintaining an antitumor response. Here, we show that the presence conventional type 1 DCs (cDC1), a DC subtype excels cross-presentation, correlated with response neoadjuvant immune checkpoint blockade (ICB) melanoma. led us hypothesize patients failing respond ICB could benefit from...
<p>Supplementary Data file, Figure S1-S9, Table S1</p>