A5029732479- Posttraumatic Stress Disorder Research
- Migration, Health and Trauma
- Prenatal Screening and Diagnostics
- Cancer Genomics and Diagnostics
- Resilience and Mental Health
- Single-cell and spatial transcriptomics
- Genomic variations and chromosomal abnormalities
- Traumatic Brain Injury Research
- Child Abuse and Trauma
- Cognitive Abilities and Testing
- Child and Adolescent Psychosocial and Emotional Development
- Pluripotent Stem Cells Research
- Digital Mental Health Interventions
- Behavioral Health and Interventions
- Suicide and Self-Harm Studies
- Renal and related cancers
- Racial and Ethnic Identity Research
- Psychosomatic Disorders and Their Treatments
- Children's Physical and Motor Development
- Obesity, Physical Activity, Diet
- Impact of Technology on Adolescents
- Genetic Syndromes and Imprinting
- Youth Substance Use and School Attendance
- Psychotherapy Techniques and Applications
- Physical Activity and Health
Academic Center for Dentistry Amsterdam
2025
University of Amsterdam
2025
Vrije Universiteit Amsterdam
2008-2025
Arq Psychotrauma Expert Group
2015-2024
Foundation Centrum '45
2013-2024
Moore College of Art and Design
2019
GGZ Drenthe
2019
Utrecht University
2019
Hudson Institute
2018
KU Leuven
2011-2016
Abstract Most human pre-implantation embryos are mosaics of euploid and aneuploid cells. To determine the fate cells developmental potential mosaic embryos, here we generate a mouse model chromosome mosaicism. By treating with spindle assembly checkpoint inhibitor during four- to eight-cell division, efficiently cells, resulting in embryo death peri-implantation development. Live-embryo imaging single-cell tracking chimeric containing reveal that depends on lineage: fetal lineage eliminated...
The nature and pace of genome mutation is largely unknown. Because standard methods sequence DNA from populations cells, the genetic composition individual cells lost, de novo mutations in are concealed within bulk signal per cell cycle rates mechanisms remain elusive. Although single-cell analyses could resolve these problems, such error-prone because whole-genome amplification (WGA) artefacts limited types that can be discerned. We developed for paired-end analysis WGA products enable (i)...
Background: In 2013, the Clinician-Administered PTSD Scale, golden standard to assess PTSD, was adapted DSM-5 (CAPS-5).Objective: This project aimed develop a clinically relevant Dutch translation of CAPS-5 and investigate its psychometric properties.Method: We conducted stepped including Delphi rounds with crowd 44 psychotrauma experts five senior experts. Using partial crowd-translations, two professional translations official DSM-5, each expert aggregated one independent translation....
Aims and method This study aimed to identify predictors of symptom severity for post-traumatic stress disorder (PTSD) depression in asylum seekers refugees referred a specialised mental health centre. Trauma exposure (number domain event), refugee status PTSD were assessed 688 refugees. Results Symptom was significantly associated with lack accumulation traumatic events. Four domains events (human rights abuse, necessities, loss, separation from others) not uniquely severity. All factors...
Background: Psychological resilience is a distinct factor that affects mental health outcomes after adversities. This study describes the development, validity and measurement invariance (MI) of Dutch English scale on psychological resilience, called Resilience Evaluation Scale (RES). Methods: Separate online surveys with version RES hypothesized related measures were distributed in Dutch- English-speaking group, both drawn from general population. Results: Exploratory analysis, using data...
Background: Questionnaires are widely used to assess the mental health status of refugees, whereas their construct validity largely remains unexplored. Objective: This study examined two widely-used instruments for assessment PTSD symptoms (Harvard Trauma Questionnaire [HTQ]; 16 items) and anxiety depression (Hopkins Symptom Check list-25 [HSCL-25]; 25 among Dutch refugee patients with different linguistic backgrounds. Method: We applied exploratory factor analyses measurement invariance...
Single-cell genomics is revolutionizing basic genome research and clinical genetic diagnosis. However, none of the current or methods for single-cell analysis distinguishes between a cell in G1-, S- G2/M-phase cycle. Here, we demonstrate by means array comparative genomic hybridization that charting DNA copy number landscape S-phase requires conceptually different approaches to G1- G2/M-phase. Remarkably, despite whole-genome amplification artifacts, log2 intensity ratios single cells...
Recently, a high incidence of chromosome instability (CIN) was reported in human cleavage stage embryos. Based on the copy number changes that were observed blastomeres it hypothesized breakages and fusions occur frequently embryos instigate subsequent breakage-fusion-bridge cycles. In addition, DNA breaks present spermatozoa could trigger this CIN. To test these hypotheses, we genotyped both parents as well 93 from 24 IVF developed novel single nucleotide polymorphism (SNP) array-based...
The clinical relevance of negative changes in cognitions about oneself, others, and the world is reflected diagnostic criteria for posttraumatic stress disorder (PTSD) DSM-5 complex ICD-11. Although such cognition have been posited to be especially relevant traumatised refugees, few studies examined this refugee populations. present study used a cross-sectional design compare among 213 adult treatment-seeking refugees with those previously published samples from general population, veterans...
Background: Trauma-focused psychotherapies for posttraumatic stress disorder (PTSD) have been demonstrated to be efficacious, but also considerable non-response and dropout rates. Intensive treatment may lead faster symptom reduction, which contribute motivation thereby reduction of dropout. Objective: The aim the current study was investigate feasibility preliminary effectiveness an intensive five-day inpatient with Eye Movement Desensitization Reprocessing (EMDR) trauma-informed yoga...
Background: During peacekeeping missions, military personnel may be involved in or exposed to potentially morally injurious experiences (PMIEs), such as an inability intervene due a limited mandate. While exposure transgressive events has been shown lead moral injury combat veterans, research on peacekeepers is limited.
An increasing number of studies have been investigating the co-occurrence posttraumatic symptoms and dissociation in trauma-exposed samples. As traumatized refugees are particularly susceptible to developing stress disorder (PTSD), aim this study was investigate relationship between PTSD a refugee sample. Cross-sectional data from clinical sample (N = 526) were collected. Latent class analysis (LCA) examined different classes PTSD, based on Clinician Administered Scale for DSM-5 (CAPS-5)...
To determine the effect of age, sex and cohort on prevalence genetic architecture adolescent alcohol use (AAU).Survey study in participants registered with Netherlands Twin Register.Twins from general population.Two cohorts (data collected 1993 2005-08) twins aged 13-15, 16-17 18-21 years. In 2005-08 a total 3269 8207 twins, respectively, took part.Survey data initiation frequency quantity consumed.The increased between for both males females. The largest difference was girls observed at...
Background: Refugees often suffer from trauma-related psychopathology, specifically posttraumatic stress disorder (PTSD). Negative world assumptions are strongly correlated with the development, course, and severity of PTSD.
This study tests in a genetically informative design whether exercise behavior causally influences subjective wellbeing (SWB) and internalizing problems (INT). If SWB INT, genetic environmental factors influencing will also influence INT. Furthermore, within identical (MZ) twin pairs, the who exercises more should show higher levels of lower than co-twin less, because confounding is excluded. Data on these phenotypes were available sample 6317 adolescent twins 1180 non-twin-siblings. Most...
Migration puts refugees in a completely new social context when simultaneously some have to deal with previously experienced traumatic events and post-migration stressors. Social capital sense of coherence could be key resources improve mental health refugees. This study aims examine the interplay between (structural cognitive), Netherlands.
The aim of this study was to investigate the degree which genetic and environmental influences affect variation in adolescent exercise behavior. Data on regular leisure time activities were analyzed 8,355 twins, from three-age cohorts (13-14, 15-16, 17-19 years). Exercise behavior assessed with survey items about type exercise, frequency, duration activities. Participants classified as sedentary, exercisers, or vigorous exercisers. prevalence moderate declined age 13 19 years a parallel...
Abstract The World Assumption Scale (WAS) is a frequently used measure in trauma research. 32 items of the WAS are intended to represent eight assumptions about benevolence world, meaningfulness events, and worthiness self. Debate validity ongoing, particularly terms its empirical factor structure; some studies have confirmed model correlated factors whereas several other not. were administered clinical sample patients who sought professional help because posttraumatic complaints ( n =...
Carriers of balanced translocations are at high risk for unbalanced gametes which can result in recurrent miscarriages or birth defects. Preimplantation genetic diagnosis (PGD) is often offered to select embryos. This selection currently mainly performed by array CGH on blastomeres. Current methodology does not take into account the phase cell cycle, despite variable copy number status different genomic regions S phase. Cell lines derived from 3 patients with chromosomal imbalances were used...