A5019154098- BRCA gene mutations in cancer
- Advanced Causal Inference Techniques
- CRISPR and Genetic Engineering
- Lymphoma Diagnosis and Treatment
- Statistical Methods and Inference
- Genetics, Bioinformatics, and Biomedical Research
- Prostate Cancer Diagnosis and Treatment
- CAR-T cell therapy research
- Sepsis Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Hematopoietic Stem Cell Transplantation
- Health Literacy and Information Accessibility
- Immune Cell Function and Interaction
- Statistical Methods and Bayesian Inference
- Health Systems, Economic Evaluations, Quality of Life
- Mobile Health and mHealth Applications
- Chronic Lymphocytic Leukemia Research
- Healthcare Policy and Management
- Transplantation: Methods and Outcomes
- Gastric Cancer Management and Outcomes
- Prostate Cancer Treatment and Research
- Medical Imaging Techniques and Applications
- Statistical Methods in Clinical Trials
- Cancer, Hypoxia, and Metabolism
- Metastasis and carcinoma case studies
Washington University in St. Louis
2018-2025
Alvin J. Siteman Cancer Center
2023
Center for Clinical Research (United States)
2007-2023
Mayo Clinic in Arizona
2023
Maine Farmland Trust
2023
American College of Surgeons
2022
Digital Scholar (United States)
2022
Columbus Oncology and Hematology Associates
2022
Barnes-Jewish Hospital
2021
Jewish Hospital
2021
Smoking is the leading preventable cause of premature death in United States. Previous studies financial incentives for smoking cessation work settings have not shown that such significant effects on rates, but these had limited power, and used may been insufficient.We randomly assigned 878 employees a multinational company based States to receive information about smoking-cessation programs (442 employees) or plus (436 employees). The were $100 completion program, $250 within 6 months after...
Limited information about the relationship between specific mutations in BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists.
Natural killer (NK) cells are innate lymphoid that eliminate cancer cells, produce cytokines, and being investigated as a nascent cellular immunotherapy. Impaired NK cell function, expansion, persistence remain key challenges for optimal clinical translation. One promising strategy to overcome these is cytokine-induced memory-like (ML) differentiation, whereby acquire enhanced antitumor function after stimulation with interleukin-12 (IL-12), IL-15, IL-18. Here, reduced-intensity conditioning (RIC)
Importance Breast cancer in young women has a less favorable prognosis compared with older women. Yet, comprehensive data on recent trends and how period cohort effects may affect these among are not well-known. Objective To evaluate breast incidence the US over 20-year by race ethnicity, hormone receptor status (estrogen [ER] progesterone [PR]), tumor stage, age at diagnosis, as well trends. Design, Setting, Participants This cross-sectional study used from Surveillance, Epidemiology, End...
Propensity Score Matching (PSM) stands as a widely embraced method in comparative effectiveness research. PSM crafts matched datasets, mimicking some attributes of randomized designs, from observational data. In valid design where all baseline confounders are measured and matched, the would be balanced, allowing treatment status to considered if it were randomly assigned. Nevertheless, recent research has unveiled different facet PSM, termed "the paradox". As approaches exact matching by...
Prostate-specific antigen screening has led to an increase in the diagnosis and treatment of localized prostate cancer. However, role active low- intermediate-risk disease elderly men is controversial.To estimate association between (with radiation therapy or radical prostatectomy) compared with observation overall survival cancer.Observational US cohort from Surveillance, Epidemiology, End Results Medicare data.At total 44,630 aged 65 80 years who were diagnosed 1991 1999 organ-confined,...
As health information technology grows, secondary uses of personal offer promise in advancing research, public health, and care. Public perceptions about sharing data are important for establishing evaluating ethical regulatory structures to oversee the use these data.To measure patient preferences their electronic purposes (other than own care).In this conjoint analysis study, we surveyed 3336 adults (568 Hispanic, 500 non-Hispanic African American, 2268 white); participants were randomized...
Knowing predictors of pregnancy in IVF is helpful for clinicians to individualize the treatment plans and improve patient counseling patients decide whether undergo infertility treatment. The aim study was identify independent chance clinical after a completed IVF/ICSI cycle (fresh plus cryopreserved embryos transferred from one stimulated cycle) compare predictive value important identified.This single center, retrospective 2450 infertile women undergoing their first between 2002 2007. A...
Several node staging schemes have been proposed for gastric cancer. The optimal system remains controversial.Patients with cancer were identified from the Surveillance, Epidemiology, and End Results (SEER) database, a Chinese patient cohort was used independent validation. prognostic performance of three compared, involving number-based scheme (pN), ratio-based (rN) log odds positive lymph nodes (LODDS).There 12 443 patients in SEER database 866 cohort. LODDS provided better discriminatory...
Donor hematopoietic clones with pathogenic mutations engraft and persist in unrelated stem cell transplant recipients.
The objective of this study was to evaluate whether orally administered anti-infectives increase the risk severe hypoglycemia in users glipizide or glyburide. We performed two case–control studies and case–crossover using US Medicaid data. All examined were associated with an elevated hypoglycemia. Using cephalexin as reference category, users, statistically significant associations found co-trimoxazole (odds ratio (OR) = 3.14; 95% confidence interval (CI): 1.83–5.37); clarithromycin (OR...
Sex hormones are linked to right ventricular (RV) function, but the relationship between genetic variation in these pathways and RV function is unknown. We performed a cross-sectional study of 2761 genotyped adults without cardiovascular disease. The relationships measures single nucleotide polymorphisms (SNPs) 10 candidate genes were assessed. Urinary oestradiol (E2) metabolites produced by cytochrome P4501B1 (CYP1B1) serum testosterone measured women men respectively. In African-American...
Most BRCA1 or BRCA2 mutation carriers have inherited a single (heterozygous) mutation. Transheterozygotes (TH) who deleterious mutations in both and are rare, the consequences of transheterozygosity poorly understood. From 32,295 female BRCA1/2 carriers, we identified 93 TH (0.3 %). "Cases" were defined as TH, "controls" at (SH1) (SH2). Matched SH1 carried found "case". SH2 After matching with SH2, 91 matched to 9316 SH1, 89 3370 SH2. The majority (45.2 %) involved three common Jewish...
Women at high lifetime breast cancer risk may benefit from supplemental magnetic resonance imaging (MRI) screening, in addition to routine mammography screening for earlier detection.We performed a cross-sectional study of 422,406 women undergoing across 86 Breast Cancer Surveillance Consortium (BCSC) facilities during calendar year 2012. We determined availability and use on-site MRI services based on woman-level characteristics, including >20% absolute using the National Institute...
Objective: We aim to report predictors of success following valve-sparing repair (VSR) for Tetralogy Fallot (TOF). Methods: performed a single-institution retrospective review 70 patients who underwent VSR TOF from 2007 2021. Risk factors moderate severe pulmonary insufficiency (PI) and surgical or catheter intervention right ventricular outflow tract (RVOT) obstruction were analyzed. Results: During median follow-up time 6 years (range 1 month 17 years), 5/70 (7%) required isolated RVOT...
Diabetic foot ulcer (DFU) is a common complication of diabetes. It often accompanied by infection and, in severe cases, necessitates amputation. Early diagnosis and monitoring are crucial for improving prognosis. Novel inflammatory biomarkers, such as the systemic response index (SIRI), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR) useful predicting prognosis some diseases. This study aimed to clarify association between SIRI, NLR, PLR DFU assess their utility early DFU....
Abstract Background and Objectives The role of tumor size should not be neglected in the management gastric cancer its prognostic value needs precise reevaluation. Methods survival data 513 patients who underwent radical resection between 2000 2005 were collected retrospectively. Tumor size, measured as maximum diameter tumor, was categorized into four subgroups (≤2, ≤3, ≤5, >5 cm) using method minimizing estimated average expected distance (AED) objective function. correlation other...
Inherited BRCA1 mutations confer elevated cancer risk. Recent studies have identified genes that encode proteins interact with as modifiers of BRCA1-associated breast cancer. We evaluated a comprehensive set most known interactors to evaluate the role these A cohort 2,825 mutation carriers was used association haplotypes at ATM, BRCC36, BRCC45 (BRE), BRIP1 (BACH1/FANCJ), CTIP, ABRA1 (FAM175A), MERIT40, MRE11A, NBS1, PALB2 (FANCN), RAD50, RAD51, RAP80, and TOPBP1, associated time ovarian...