A5025757664- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- BRCA gene mutations in cancer
- Intraperitoneal and Appendiceal Malignancies
- Renal cell carcinoma treatment
- Cervical Cancer and HPV Research
- Molecular Biology Techniques and Applications
- Uterine Myomas and Treatments
- Genetic Associations and Epidemiology
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- RNA Research and Splicing
- DNA Repair Mechanisms
- Endometriosis Research and Treatment
- PARP inhibition in cancer therapy
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Reproductive Biology and Fertility
- Chromatin Remodeling and Cancer
- MRI in cancer diagnosis
- Childhood Cancer Survivors' Quality of Life
- Lymphoma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Nutrition, Genetics, and Disease
Washington University in St. Louis
2025
National Cancer Institute
2003-2023
Center for Cancer Research
2003-2023
University of Pittsburgh
2009-2022
Magee-Womens Hospital
2012-2022
University of Arkansas for Medical Sciences
2014-2022
Winthrop Rockefeller Foundation
2018-2021
Ospedale di Circolo e Fondazione Macchi
2017
Mon Health Medical Center
2016
Hahnemann University Hospital
2016
Abstract Purpose: The presence of similar histologic subtypes epithelial ovarian and endometrial cancers has long been noted, although the relevance this finding to pathogenesis clinical management is unclear. Despite characteristics, ovary endometrium are treated according organ origin. This study compares gene expression profiles analogous using same genomic platform determine similarities differences between these tumors. Experimental Design: Gene 75 (endometrioid, serous, clear cell)...
Abstract Purpose: The goal of this study was to determine whether distinct gene expression profiles are associated with intrinsic and/or acquired chemoresistance in epithelial ovarian carcinoma. Experimental Design: Gene were generated from 21 primary chemosensitive tumors and 24 chemoresistant using cDNA-based microarrays. both groups then compared those 15 carcinomas obtained following platinum-based chemotherapy (“postchemotherapy” tumors). A theme discovery tool used identify functional...
BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity data exists on the pathology cancers (BCs) in men BRCA1/2 mutations. Using largest available dataset, we determined whether MBCs arising mutation carriers display specific pathologic features and these differ from those female BCs (FBCs). We characterised 419 using logistic regression analysis, contrasted 9675 FBCs population-based 6351 Surveillance, Epidemiology,...
Most BRCA1 or BRCA2 mutation carriers have inherited a single (heterozygous) mutation. Transheterozygotes (TH) who deleterious mutations in both and are rare, the consequences of transheterozygosity poorly understood. From 32,295 female BRCA1/2 carriers, we identified 93 TH (0.3 %). "Cases" were defined as TH, "controls" at (SH1) (SH2). Matched SH1 carried found "case". SH2 After matching with SH2, 91 matched to 9316 SH1, 89 3370 SH2. The majority (45.2 %) involved three common Jewish...
Abstract BACKGROUND: The objective of the current study was to determine prognostic significance a pretreatment serum CA 125 level in patients with advanced epithelial ovarian carcinoma (EOC) who received treatment standard chemotherapy regimen. METHODS: Patients International Federation Gynecology and Obstetrics stage III/IV were on 1 7 Gynecologic Oncology Group (GOG) phase 3 trials regimen intravenous cisplatin paclitaxel included. A Cox regression model used assess impact levels drawn...
In response to the critical shortage of Doxil(®), US Food and Drug Administration (FDA) allowed temporary importation non-FDA-approved second-generation liposomal doxorubicin, Lipo-Dox(®). Lipo-Dox utilizes a different particle than Doxil demonstrates pharmacokinetic properties. Its use has never been evaluated in North American population. The objective this study was evaluate efficacy tolerability at Magee-Womens Hospital, University Pittsburgh Medical Center, for patients with recurrent...
Recent evidence suggests that hyperinsulinemia associated with obesity may be a significant risk factor for the development of endometrial cancer. Metformin is used in type II diabetes to lower circulating insulin levels. We sought examine our obese patients cancer and those who were on metformin determine any impact their course.A retrospective review all women diagnosis body mass index 30 kg/m(2) or higher during 6-year period (2005-2011) at institution was conducted. Records reviewed...
Self-advocacy, defined as a cancer survivor's ability to get his or her needs met in the face of challenge, is critical skill for those facing overwhelming disease and psychological burdens (Hagan & Donovan, 2013a, 2013b). Self-advocacy consists three main skills: (a) making informed decisions, (b) finding strength through connection with others, (c) communicating effectively oncology care team.
Objective The objective of the study was to examine outcomes in stage IB2 cervical cancer patients undergoing primary surgery versus radiation. Methods Stage were identified from Surveillance, Epidemiology and End Results Public-Use Database 2000 2006. Patients divided into those receiving radiation (radiation first) or (surgery as initial treatment. Overall survival calculated by Kaplan-Meier method compared using log-rank test. In total, 770 with cancer; 369 received radiation, 401...
To develop and psychometrically test the validity of Female Self-Advocacy in Cancer Survivorship Scale.Female cancer survivors need to self-advocate overcome challenges associated with yet no valid measure self-advocacy exists.Instrument development. Mixed-mode cross-sectional survey design.We recruited adult females (18+ years; N = 317) a history invasive from local national tumour registries advocacy organizations complete online or paper questionnaires.Between July 2014 - March 2015...
Recurrent vulvar carcinoma with metastasis has few effective treatment options, which are mainly directed toward palliation of symptoms. A 70-year-old woman was originally treated in 1999 for squamous cell (SCC) radical vulvectomy and bilateral inguinofemoral groin dissection. She represented 2005 a new lesion distinct from the margin her first disease occurrence. Although this area included surgical resection chemoradiation, she recurred 3 months later. Despite an anal perineal resection,...