A5071215493- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Coronary Artery Anomalies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Issues in Pregnancy
- Heart Failure Treatment and Management
- Congenital Diaphragmatic Hernia Studies
- Kawasaki Disease and Coronary Complications
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Aortic Disease and Treatment Approaches
- Vasculitis and related conditions
- Neonatal Respiratory Health Research
- Liver Disease and Transplantation
- Cardiac Structural Anomalies and Repair
- Vascular anomalies and interventions
- Phosphodiesterase function and regulation
- Renal and related cancers
- Ultrasound in Clinical Applications
- Medical Imaging and Pathology Studies
- Freezing and Crystallization Processes
- Cardiovascular Effects of Exercise
- Viral Infections and Immunology Research
Children's Hospital of Wisconsin
2015-2025
Medical College of Wisconsin
2013-2025
Riley Hospital for Children
2006-2008
Boston Children's Hospital
2006
Indiana University School of Medicine
2004
Indiana University
2004
University School
2004
Early treatment with intravenous immunoglobulin (IVIG) is necessary to help reduce the risk of coronary artery abnormalities, such as aneurysms and alleviate symptoms, in Kawasaki disease. Some patients, however, do not respond an initial dose IVIG require additional doses. Prediction these nonresponders may be assistance altering therapy make it more effective. The Egami score has been validated Japanese population predict but shown ineffective US populations. This study evaluates a Midwest...
ABSTRACT Pulmonary arterial endothelial and smooth muscle cell homeostasis is regulated through the bone morphogenetic protein (BMP) transforming growth factor beta (TGF‐β) receptor pathways. Pathway imbalance results in pulmonary hypertension (PH). Each pathway has ligands modulators influencing this balance. How these pathways differ pediatric PH patients unknown. Ten 20 control subjects (ages 2–17 years) were prospectively enrolled. artery serum BMP 2, 4, 6, 7, 9, 10, activin A, TGF‐β1,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFurther Observations Concerning the Crystallization of Undercooled LiquidsWilliam T. Richards, Edward C. Kirkpatrick, and Carl E. HutzCite this: J. Am. Chem. Soc. 1936, 58, 11, 2243–2248Publication Date (Print):November 1, 1936Publication History Published online1 May 2002Published inissue 1 November 1936https://pubs.acs.org/doi/10.1021/ja01302a047https://doi.org/10.1021/ja01302a047research-articleACS PublicationsRequest reuse permissionsArticle...
Treprostinil, a prostacyclin analogue, is approved for the treatment of pulmonary arterial hypertension (PAH) in adults. Transition from parenteral to oral treprostinil has been successfully accomplished adults with PAH but not children. In this multicenter study, pediatric patients treated (Cohort 1) or inhaled 2) were transitioned treprostinil. Prostacyclin-naïve individuals on background therapy received as add-on 3). Successful transition was dose maintenance through week 24. Patients...
The aim of this study is to evaluate quality life in four domains (physical, emotional, social, and school) pediatric patients with pulmonary hypertension (PH) using a validated survey (PedsQL). This prospective cohort aged 2-18 years PH. Parents all children 8-18 appropriate developmental capacity completed the PedsQL clinic. Results were compared published norms for patients, those congenital heart disease (CHD) cancer. Thirty-three enrolled yielding 32 parent 18 patient self-reports:...
We present a patient with complex single ventricle physiology who was subsequently diagnosed atresia of the coronary sinus ostium in setting myocardial dysfunction following operative palliation. Although rare cardiac defect, awareness is important as venous system will often drain to left superior vena cava (LSVC). If LSVC ligated without knowing this and death can occur.
Objective: Kawasaki Disease (KD) is one of the most common vasculitides childhood. Its precise pathophysiology, however, not very well understood. KD occurs frequently in southeastern Asian, particularly Japanese, populations and, thus, has been described extensively this population. The American population markedly different, having a significantly greater degree racial hetero geneity. There paucity data regarding differences among different races This study characterizes and compares...
As part of a clinical trial, this study examined the pharmacokinetics (PK) oral treprostinil (TRE) in children with pulmonary arterial hypertension. The trial consisted following 3 cohorts: transition from parenteral (cohort 1) or inhaled 2) TRE, de novo addition 3). Oral TRE was dosed times daily. PK samples were obtained before an dose, and at 2, 4, 6, 8 hours thereafter. parameters calculated using noncompartmental analysis. Thirty-two (n = 10 cohorts 1 n 12 cohort 3) enrolled; median age...