A5052633287- Hydrogels: synthesis, properties, applications
- Bone Tissue Engineering Materials
- biodegradable polymer synthesis and properties
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Polymer Surface Interaction Studies
- Osteoarthritis Treatment and Mechanisms
- Silk-based biomaterials and applications
- Tissue Engineering and Regenerative Medicine
- Wound Healing and Treatments
- Additive Manufacturing and 3D Printing Technologies
- Polymer Nanocomposites and Properties
- Graphene and Nanomaterials Applications
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- Carbon dioxide utilization in catalysis
- Polymer crystallization and properties
- Knee injuries and reconstruction techniques
- Advanced Sensor and Energy Harvesting Materials
- Biopolymer Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Periodontal Regeneration and Treatments
- Dental Implant Techniques and Outcomes
- Mesenchymal stem cell research
- Biochemical Acid Research Studies
Shanghai University
2016-2025
Hunan University of Science and Technology
2020
Ningbo Institute of Industrial Technology
2019
Chinese Academy of Sciences
2008-2019
Ningbo University of Technology
2019
State Council of the People's Republic of China
2015-2018
Shanghai Jiao Tong University
2011-2014
Chinese Academy of Medical Sciences & Peking Union Medical College
2012
State Key Laboratory of Polymer Physics and Chemistry
2008-2011
Changchun Institute of Applied Chemistry
2008-2011
Tough and self-adhesive zwitterionic hydrogels with ionic conductivity have been prepared, showing high linear strain sensitivity for detecting human motions.
Injectable hydrogels as an important biomaterial class have been widely used in regenerative medicine. A series of injectable poly(l-glutamic acid)/alginate (PLGA/ALG) were fabricated by self-cross-linking hydrazide-modified acid) (PLGA-ADH) and aldehyde-modified alginate (ALG-CHO). Both the degree PLGA modification oxidation ALG-CHO could be adjusted amount activators sodium periodate, respectively. The effect solid content on gelation time, equilibrium swelling, mechanical properties,...
Abstract Ionic conductive hydrogels have emerged as an excellent option for constructing dielectric layers of interfacial iontronic sensors. Among these, gradient ionic hydrogels, due to the intrinsic elastic modulus, can achieve a wide range pressure responses. However, fabrication with optimal mechanical and sensing properties remains challenge. In this study, it is discovered first that phytic acid (PA) interacts in remarkably distinct manners (i.e., plasticizing effects phase separation)...
Self-healing polymeric hydrogels have the capability to recover their structures and functionalities upon injury, which are extremely attractive in emerging biomedical applications. This research reports a new kind of self-healing polypeptide based on self-assembly between cholesterol (Chol)-modified triblock poly(L-glutamic acid)-block-poly(ethylene glycol)-block-poly(L-glutamic acid) ((PLGA-b-PEG-b-PLGA)-g-Chol) β-cyclodextrin (β-CD)-modified (PLGA-g-β-CD). The hydrogel formation relied...
The hierarchical microstructure, surface and interface of biomaterials are important factors influencing their bioactivity. Porous bioceramic scaffolds have been widely used for bone tissue engineering by optimizing chemical composition large-pore structure. However, the struts in often ignored. aim this study is to incorporate pores bioactive components into constructing nanopores elements on further improve bone-forming activity. Mesoporous glass (MBG) modified β-tricalcium phosphate...
Injectable hydrogels have aroused much attention for the advantages such as minimally invasive surgery, avoidance of surgical trauma, and filling repairing irregularly shaped tissue defects. Mussel-inspired injectable can be immobilized on surface tissues, resulting in stable biomaterial-tissue integration. However, commonly used biomimetic mussel-inspired are prepared by oxidation catechol groups, which involves introduction or production cytotoxic substances. Moreover, generally display...
Chitosan (CS) hydrogels are widely used in wound hemostatic agents due to their superior biocompatibility, biodegradability, and effect. However, most of them fail achieve great effect because poor adhesion bleeding tissues. Also, the conventional implantation surgery internal wounds may cause secondary trauma human body. In this work, catechol-hydroxybutyl chitosan (HBCS-C) has been designed prepared by grafting hydroxybutyl groups catechol CS backbones. The multifunctional HBCS-C...
Injectable hydrogels have received much attention because of the advantages simulation natural extracellular matrix, microinvasive implantation, and filling repairing complex shape defects. Yet, for bone repair, current injectable shown significant limitations such as lack tissue adhesion, deficiency self-healing ability, absence osteogenic activity. Herein, a strategy to construct mussel-inspired bisphosphonated nanocomposite with adhesive, self-healing, properties is developed. The...
Injectable, in situ forming hydrogels have exhibited many advantages regenerative medicine. Herein, we present the novel design of poly(l-glutamic acid) injectable via self-crosslinking adipic dihydrazide (ADH)-modified (PLGA-ADH) and aldehyde-modified (PLGA-CHO), investigate their potential cartilage tissue engineering. Both hydrazide modification degree PLGA-ADH oxidation PLGA-CHO can be adjusted by amount activators sodium periodate, respectively. Experiments reveal that solid content...
For tissue regeneration or repair, a suitable temporary scaffold needs to be constructed for delivering regenerative cells damaged diseased tissue. Scaffold types are currently categorised into 3D monolithic scaffolds, hydrogels, and microcarriers. Among these microcarrier systems offer an attractive method cell amplification enhancement of phenotype expression, they have emerged as powerful injectable carriers repair reconstruct irregular defects in tissues organs. In this article, several...