A5066444914- Osteoarthritis Treatment and Mechanisms
- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- Wound Healing and Treatments
- Corneal Surgery and Treatments
- Fibroblast Growth Factor Research
- Skin Diseases and Diabetes
- Silk-based biomaterials and applications
- Advanced Technologies in Various Fields
- Dermatologic Treatments and Research
- Hydrogels: synthesis, properties, applications
- Meningioma and schwannoma management
- Atrial Fibrillation Management and Outcomes
- Congenital limb and hand anomalies
- Corneal surgery and disorders
- Angiogenesis and VEGF in Cancer
- Natural Compounds in Disease Treatment
- Ophthalmology and Eye Disorders
- AI and Multimedia in Education
- Trace Elements in Health
- AI and Big Data Applications
- Proteoglycans and glycosaminoglycans research
- Reconstructive Surgery and Microvascular Techniques
- Sirtuins and Resveratrol in Medicine
- Neurogenetic and Muscular Disorders Research
Zhengzhou Normal University
2024
Institute of Computing Technology
2024
Zhangqiu City People's Hospital
2023
Harbin Medical University
2018-2023
First Affiliated Hospital of Harbin Medical University
2018-2023
Shanghai East Hospital
2019-2022
Tongji University
2017-2019
Shanghai Tenth People's Hospital
2019
Tongji Hospital
2017
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
2015
Damaged hyaline cartilage has no capacity for self-healing, making osteoarthritis (OA) "difficult-to-treat". Cartilage destruction is central to OA patho-etiology and mediated by matrix degrading enzymes. Here we report decreased expression of miR-17 in osteoarthritic chondrocytes its deficiency contributes progression. Supplementation exogenous or endogenous induction growth differentiation factor 5, effectively prevented simultaneously targeting pathological catabolic factors including...
We investigated the feasibility of intra-articular injection resveratrol for preventing progression existing cartilage degeneration in a mouse model osteoarthritis (OA). The effects on expression silent information regulator 2 type 1 (SIRT1), hypoxia-inducible factor-2α (HIF-2α) and catabolic factors OA was explored. induced knee via destabilization medial meniscus (DMM). Resveratrol injected weekly into operated beginning 4 weeks after surgery. phenotype evaluated histological...
Alopecia has become an exceedingly prevalent dermatological disorder. Etiologically, infection (bacterial and fungal infection), inflammation, immune dysregulation are the main causes of immune-mediated hair loss. Treating loss remained challenging as available therapies limited. Exosomes from adipose-derived stem cells (ADSC-Exos) have been used for treating neurodegenerative diseases autoimmune in wound-healing treatments. However, function mechanism ADSC-Exos alopecia treatment remain...
Purpose: Subconjunctival injection of antagomir-21 attenuates the progression corneal neovascularization. We examined underlying mechanism by investigating regulation microRNA (miR)-21 expression and involvement miR-21 in homeostasis epithelial cells. Methods: Corneal cells were cultured with TGF-β1 and/or under hypoxia conditions. was measured quantitative PCR. The direct targets validated 3′-UTR luciferase reporter assay. Alterations proangiogenic signaling epithelial-mesenchymal...
Acellular corneal stroma matrix has been used for engineering. However, because of its compact tissue structure, regrowth keratocytes into the scaffold is difficult. Previously, we developed a sandwich model cartilage engineering using acellular sheets. In present study, tested this regeneration porcine (APCS) sheets and keratocytes. Porcine corneas were decellularized by NaCl treatment, APCS was cut 20-μm-thick A rabbit defect created lamellar keratoplasty repaired transplantation five...
Background: Although adiponectin has been implicated as an antiinflammatory factor in atherosclerotic lesion development, little is known about its role advanced plaque. This study assessed the effect and mechanism of on expression prolyl 4-hydroxylase (P4H) α1 stability preexisting Methods Results: Atherosclerotic lesions carotid arteries apolipoprotein E-deficient mice were induced by placement a perivascular collar. Six weeks after surgery, 120 divided into phosphate-buffered saline (PBS)...
ABSTRACT Staphylococcus aureus ( S. ) is the most popular pathogen found in septic arthritis. Despite bacteria was eradicated from joint cavity during acute infection, destruction of articular cartilage often continues for years, leading to permanent damage. The mechanism responsible this consistent catabolic reaction arthritis remains unclear. Here, we that fermentation supernatant (FS) accelerated dedifferentiation chondrocytes and induced expression factors including A Disintegrin‐like...
This study assesses the feasibility, safety, and effectiveness of noninvasive stereotactic body radiotherapy (SBRT) as an approach for pulmonary artery denervation in canine models. SBRT with CyberKnife resulted reduced mean pressure, capillary wedge vascular resistance, insignificantly increased cardiac output. In comparison to control group, serum norepinephrine levels at 1 month 6 months were significantly lower group. Computed tomography, angiography, histology analysis revealed that was...
In current research on task offloading and resource scheduling in vehicular networks, vehicles are commonly assumed to maintain constant speed or relatively stationary states, the impact of variations is often overlooked. It frequently that can be accurately modeled during actual motion processes. However, dynamic environments, both tasks generated by vehicles' surroundings constantly changing, making it difficult achieve real-time modeling for network scenarios. Taking into account...