Xianjun Chen

ORCID: 0000-0003-2041-2638
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About
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Research Areas
  • Postharvest Quality and Shelf Life Management
  • Intracranial Aneurysms: Treatment and Complications
  • Magnolia and Illicium research
  • Healthcare and Venom Research
  • Plant Stress Responses and Tolerance
  • Retinal Diseases and Treatments
  • Cerebrovascular and Carotid Artery Diseases
  • Medicinal Plant Pharmacodynamics Research
  • MicroRNA in disease regulation
  • Photosynthetic Processes and Mechanisms
  • Plant Water Relations and Carbon Dynamics
  • Genetic factors in colorectal cancer
  • Horticultural and Viticultural Research
  • Artificial Intelligence in Healthcare
  • Food Drying and Modeling
  • Genomic variations and chromosomal abnormalities
  • Genetics and Neurodevelopmental Disorders
  • Biopolymer Synthesis and Applications
  • Machine Learning in Healthcare
  • Infrared Thermography in Medicine
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Circular RNAs in diseases
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Flavonoids in Medical Research
  • Educational Robotics and Engineering

Affiliated Hospital of Guizhou Medical University
2025

Guiyang Medical University
2025

Fujian Medical University
2024

Kaili University
2024

Shihezi University
2024

Ningbo No. 2 Hospital
2023

Jiangxi Provincial People's Hospital
2021-2023

China Agricultural University
2022-2023

Nanchang University
2021-2023

Army Medical University
2019-2021

The growing population of elderly neurocritically ill patients highlights the need for effective prognosis prediction tools. This study aims to develop and validate machine learning (ML) models predicting 28-day mortality in intensive care units (ICUs). Data were extracted from Medical Information Mart Intensive Care IV(MIMIC-IV) database, focusing on neurocritical with ICU stays ≥ 24 h. cohort was split into 70 % training 30 internal validation. We analyzed 58 variables, including...

10.1016/j.cmpb.2025.108589 article EN cc-by-nc-nd Computer Methods and Programs in Biomedicine 2025-01-06

Salt stress is a critical abiotic factor that adversely affects plant growth and productivity by impairing photosynthesis. This study explores the impact of exogenous ascorbic acid (AsA) on photosynthetic performance tomato seedlings (Solanum lycopersicum L. cv. Ligeer 87-5) under salt stress. Hydroponic experiments were conducted in solar greenhouse, where subjected to following five treatments: Control, NaCl, NaCl + AsA, lycorine (LYC), LYC AsA. Our findings demonstrate significantly...

10.3390/agronomy14081810 article EN cc-by Agronomy 2024-08-16

In order to explore an alternative drying method enhance the process and quality of persimmon slices, pulsed vacuum (PVD) was employed effects different temperatures (60, 65, 70, 75 °C) on kinetics, color, rehydration ratio (RR), microstructure, bioactive compounds, antioxidant capacity sliced persimmons were investigated in current work. Results showed that (RR) samples under PVD significantly higher than traditional hot air-dried ones. Compared fresh samples, dried slices indicated a...

10.3390/plants11192500 article EN cc-by Plants 2022-09-23

Objectives. Delayed cerebral ischemia (DCI) contributes to poor aneurysm prognosis. Subarachnoid hemorrhage and DCI have irreversible severe consequences once they occur; therefore, early prediction prevention are important. We investigated the risk factors for postoperative complications of in patients with aneurysmal subarachnoid (aSAH) requiring mechanical ventilation intensive care validated a model. Methods. retrospectively analyzed aSAH who were treated French university hospital...

10.1155/2023/7656069 article EN BioMed Research International 2023-01-01

To explore the predictive value of milk fat globule epidermal growth factor 8 (MFG-E8) in occurrence delayed cerebral ischemia (DCI) after an aneurysmal subarachnoid hemorrhage (aSAH).We recruited 32 patients with aSAH as case group and 24 unruptured aneurysms control group. Serum MFG-E8 levels were measured by western blot enzyme-linked immunosorbent assay. We analyzed relationship between risk DCI.The serum (mean = 11160.9 pg/mL) significantly higher than those 3081.0 pg/mL, p < 0.001)....

10.1155/2021/6568477 article EN cc-by BioMed Research International 2021-12-31

Age-related changes in visual function and retina structure are very common aged animals, but the underlying mechanisms of these remain unclear. Here we report that expression interferon regulatory factor 3 (IRF3), a critical immune factor, is dramatically down-regulated mouse retinas during aging. To address role IRF3 retina, examined young (3-4 months) old (22-24 Irf3 -/- mice comparison to age-matched wildtype (WT) mice. We found deletion resulted impaired electroretinogram (ERG)...

10.3389/fncel.2019.00272 article EN cc-by Frontiers in Cellular Neuroscience 2019-06-20

Increasing evidence has demonstrated that in addition to dysfunction of neuronal circuitry, oligodendroglial and/or disruption white matter integrity are found the brains patients with schizophrenia. DNA methylation, a well-established risk factor for schizophrenia, been cause dysfunction; however, whether dysregulation methylation contributes oligodendroglial/myelin deficits pathogenesis schizophrenia remains unclear. In present study, by using L-methionine-treated mice, we confirmed mice...

10.3389/fnins.2021.659853 article EN cc-by Frontiers in Neuroscience 2021-04-20

Abstract Background Osteomyelitis (OM) is recognized as a significant challenge in orthopedics due to its complex immune and inflammatory responses. The prognosis heavily depends on timely diagnosis, accurate classification, assessment of severity. Thus, the identification diagnostic classification‐related genes from an immunological standpoint crucial for early detection tailored treatment OM. Methods Transcriptomic data OM was sourced Gene Expression Omnibus (GEO) database, leading...

10.1002/iid3.1339 article EN cc-by Immunity Inflammation and Disease 2024-07-01

Objective. Glioblastoma is one of the most common and fatal malignancies in adults. Current treatment still not optimistic. (GBM) transports RNA to platelets blood system via microvesicles, suggesting that platelet can be a potential diagnostic therapeutic target. The roles specific RNAs GBM are well understood. Methods. Platelet profiling 8 12 normal samples were downloaded from GEO database. Differentially expressed genes (DEGs) identified between tumors samples. Gene Ontology (GO) Kyoto...

10.1155/2022/2488139 article EN cc-by BioMed Research International 2022-08-12

Abstract Background: Knee osteoarthritis (KOA) is a prevalent and debilitating form of arthritis, posing substantial burden on patients' quality life. Timely precise diagnosis pivotal in impeding disease progression averting the necessity for invasive interventions such as joint replacement surgery. Given widespread availability X-ray imaging, there exists critical need an effective diagnostic methodology KOA. Methods: In response to this need, study introduces novel computer-aided model...

10.21203/rs.3.rs-3480240/v1 preprint EN cc-by Research Square (Research Square) 2023-10-30
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