A5103228280- Neuroscience and Neuropharmacology Research
- Endometrial and Cervical Cancer Treatments
- Sleep and Wakefulness Research
- Alzheimer's disease research and treatments
- Neural dynamics and brain function
- MicroRNA in disease regulation
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Mesenchymal stem cell research
- Trauma and Emergency Care Studies
- Nutrition, Genetics, and Disease
- Surgical Simulation and Training
- Photoreceptor and optogenetics research
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Immune Response and Inflammation
- Digital Media and Visual Art
- Peer-to-Peer Network Technologies
- Liver Disease Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Neurological Disease Mechanisms and Treatments
- Open Source Software Innovations
- Multiple and Secondary Primary Cancers
- Hereditary Neurological Disorders
University of Chinese Academy of Sciences
2019-2024
Chinese Academy of Sciences
2019-2024
Shanghai Institute of Organic Chemistry
2019-2024
Central China Normal University
2024
Wuhan Institute of Physics and Mathematics
2024
Wuxi People's Hospital
2024
Nanjing Medical University
2024
Ningbo University
2024
Yuhuangding Hospital
2006-2024
Qingdao University
2006-2024
Rett syndrome (RTT) is a devastating neurodevelopmental disorder primarily caused by mutations in the methyl-CpG binding protein 2 (Mecp2) gene. Here, we found that inhibition of Receptor-Interacting Serine/Threonine-Protein Kinase 1 (RIPK1) kinase ameliorated progression motor dysfunction after onset and prolonged survival Mecp2-null mice. Microglia were activated early myeloid Mecp2-deficient mice, which was inhibited upon inactivation RIPK1 kinase. microglia reduced oxidative stress,...
Calculating the thermal rate constants of elementary combustion reactions is great importance in theoretical chemistry. Machine learning has become a powerful, data-driven method for predicting nowadays. Recently, molecular similarity combined with topological indices were proposed to represent hydrogen abstraction alkane [
Background: Borneol is the processed item from resin of Dryobalanops aromatica Gaertn. f. It can enhance activity antioxidant enzymes in brain tissue and reduce inflammatory response by improving energy metabolism ischemic regions, thereby reduces damage. The objective this paper was to study anti-cerebral ischemia effect borneol its mechanism.Materials Methods: studied ligation bilateral common carotid arteries (CCA), vagus nerves mice acute cerebral ischemia-reperfusion experiment...
The aim of the article was to evaluate important role played by insulin in development endometrial cancer (EC) among Chinese premenopausal women. In this study, 128 patients and 294 controls who were all included. Baseline characteristics data collected serum insulin, C-peptide, sex hormone-binding globulin, C-reaction protein, interleukin-6, tumor necrosis factor-α levels measured. Paired t test, χ(2) Spearman correlation coefficients, univariate multivariate logistic regression models used...
Temporal lobe epilepsy (TLE) is a severe chronic neurological disease caused by abnormal discharge of neurons in the brain and seriously affect long-term life quality patients. Currently, new insights into pathogenesis TLE are urgently needed to provide more personalized effective therapeutic strategies. Accumulating evidence suggests that sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate receptor 2 (S1PR2) signaling pathway plays pivotal role central nervous system (CNS) diseases....
The present study aimed to investigate the effects of various pharmacological agents on hippocampal expression neural cell adhesion molecule 1 (NCAM1) and extracellular signal-regulated kinase 2 (ERK2) in epileptic rats with cognitive dysfunction. experiments were conducted using 120 Wistar rats: 20 controls 100 pilocarpine-induced status epilepticus (SE). SE randomly assigned 5 groups (n=20/group) that received daily treatments for month one following: (i) saline (no effect epilepsy); (ii)...
Background: Pericytes are crucial for the development, stabilization, and functional regulation of microvasculature, especially in retina. In diabetic retinopathy (DR), early loss pericytes is a key event that drives microvascular dysfunction. Despite their critical role, mechanisms underlying heterogeneity DR remain poorly understood, impeding development effective therapeutic strategies. Methods: We employed single-cell RNA sequencing to construct comprehensive atlas non-diabetic retinas....
The hydrogen abstraction reactions by small radicals from fuel molecules play an important role in the oxidation of fuels. However, experimental measurements and/or theoretical calculations their rate constants under combustion conditions are very challenging due to high reactivity. Machine learning offers a promising approach predicting thermal constants. In this work, three machine methods, XGB, FNN, and XGB-FNN hybrid algorithms, were employed train predict between alkanes OH/HO
Abstract Introduction Myometrial invasion is a prognostic factor for lymph node metastases and decreased survival in non-endometrioid endometrial carcinoma patients. Herein, we explored the mode of myometrial diagnosis FIGO stage I evaluated differences diagnostic efficiency among intraoperative frozen section (IFS), gross examination (IGE), magnetic resonance imaging (MRI), computed tomography (CT) clinical practice. Finally, suggested which test should be routinely performed. Method This...
Antiviral drugs are widely used in populations with viral infection caused by immunologic inadequacy. Because these mainly metabolized the kidneys, patients renal failure undergoing replacement therapy prone to drug adverse effects and poisoning. Severe neurotoxicity antiviral is a rare but life-threatening complication.This study reported one male patient on peritoneal dialysis who suffered from severe mental disorders after receiving an overdose of acyclovir valacyclovir for treatment...