A5100370642- Nutritional Studies and Diet
- Cancer Genomics and Diagnostics
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Cancer Mechanisms and Therapy
- Muscle Physiology and Disorders
- Inflammatory mediators and NSAID effects
- Inflammasome and immune disorders
- Vascular Tumors and Angiosarcomas
- Obesity, Physical Activity, Diet
- Frailty in Older Adults
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Treatments and Studies
- Inflammatory Myopathies and Dermatomyositis
- Sarcoma Diagnosis and Treatment
- Public Health and Nutrition
- Surgical Sutures and Adhesives
- Hemostasis and retained surgical items
- Cardiac tumors and thrombi
- Flavonoids in Medical Research
- Chronic Disease Management Strategies
- Osteoarthritis Treatment and Mechanisms
- Cell death mechanisms and regulation
- PARP inhibition in cancer therapy
- Peroxisome Proliferator-Activated Receptors
Chinese Center For Disease Control and Prevention
2022-2024
Shandong Provincial Hospital
2018-2022
Shandong First Medical University
2020-2022
Shandong University
2015-2022
University of Shanghai for Science and Technology
2021
Jiangsu University
2016
Affiliated Hospital of Jiangsu University
2016
Abstract Small molecule drug intervention for chondrocytes is a valuable method the treatment of osteoarthritis (OA). The 4‐octyl itaconate (OI) cellular derivative with sound cell permeability and transformation rate. We attempted to confirm protective role OI in its regulatory mechanism. used lipopolysaccharide (LPS) induce chondrocyte inflammation injury. After treatment, secretion mRNA expression Il ‐ 6 , 10 Mcp 1 Tnf α were detected by ELISA qPCR. effect on articular cartilage was...
Abstract Overexpression of human epidermal growth factor receptor 2 (HER2) is observed in breast cancer. The major snag faced by the population development chemoresistance to HER2 inhibitors advanced stage cancer cells. Moreover, recent researchers focussed on fisetin as an antiproliferative and chemotherapeutic agent. Therefore, this study was intended analyze effects HER2/neu‐overexpressing cell lines. Our results depicted that induced apoptosis these cells various mechanisms, such...
Intranasal dexmedetomidine is an effective sedative for premedication and regularly used to reduce preoperative tension anxiety in children. This study aimed assess the effect of intranasally adjunctive on perioperative analgesic requirements adults.Patients were randomly divided into four groups receive administration saline, intranasal 1 μg/kg 2 μg/kg, intravenous respectively. Propofol remifentanil target-controlled infused maintain intraoperative bispectral index at 45-55 blood pressure...
As a chronic metabolic disease caused by disorders of purine metabolism, gout has shown increasing incidence rate worldwide. Considering that is not easily treated and cured, further studies are explored to prevent development through diet modification. Both β-carotin green tea powder rich in dietary fiber, which helps maintain the balance gut microbiota humans. The aim this study was investigate effects on prevention gouty arthritis relation bacterial structure mice. We successfully induced...
Patients with non-small cell lung cancer (NSCLC) containing ROS1 fusions can have a marked response to the ROS1-targeted tyrosine kinase inhibitors (TKIs), such as crizotinib. Common resistance mechanisms of ROS1-fusion targeted therapy are acquired mutations in ROS1. Along use next-generation sequencing clinical management patients NSCLC during sequential therapy, many been discovered activated receptors. Besides mutations, bypass epidermal growth factor receptor (EGFR)-TKI treatment common...
Alveolar soft-part sarcoma (ASPS) is an uncommon soft‑tissue neoplasm, which commonly found in the deep soft tissues of extremities, with a propensity for recurrence and metastasis. However, metastasis ASPS to heart exceedingly rare. The present study reports such rare case cardiac Using computed tomography, 37‑year‑old man was diagnosed brain, lung spleen metastases from previously treated left forearm. Cardiac then 1 month later. Despite chemotherapy palliative whole‑brain radiotherapy,...
Mesenteric traction syndrome (MTS), which is characterized by arterial hypotension and tachycardia following mesenteric (MT), frequently occurs during abdominal surgery. Dexmedetomidine, commonly used in general anesthesia major surgery, has a sympatholytic effect attenuates the compensatory response to hypotension.
To explore the geographical distribution of nutrition and health knowledge among 18-64 years old adults in China.A total 102 398 residents aged from 302 survey sites were selected by multi-stage cluster random sampling method, a 98 567 respondents included study. Both mean rate calculated complex weighting.The score eastern region(65.5±12.0) was higher than that central(62.4±11.9) western(61.4±12.9), northern region(63.9±11.8) southern(63.1±12.8). In seven regions, highest north(65.8±11.4),...
Objective: The objective of this study is to gain insights into the influence income on body mass index (BMI) locus in elderly population. Methods: Chinese Longitudinal Healthy Longevity and Happy Family Study (CLHLS-HF) was included at baseline (2008) for participants aged 65 years older. total number analyzed 7555. A population-based trajectory model (GBTM) used. economic level an independent variable adjusted age, gender, ethnicity, education, marriage, physical activity (Model 1), BMI...
Abstract Background: Multiple types of tumors exhibit DNA repair dysfunction via homologous recombination deficiency (HRD) due to genetic and epigenetic alterations HR pathway genes, including BRCA1/2, PALB2, ATM, ATR, CHK1/2, BARD1, BIRP1, MRE11A, RAD51 family FANC family. Some studies showed that with might result in more mutations than non-deficient HR. Accumulating evidence suggests tumor mutational burden (TMB) evaluated by comprehensive genomic profiling was associated the responses...