A5054410939- Cancer Cells and Metastasis
- Virus-based gene therapy research
- Phagocytosis and Immune Regulation
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Phytase and its Applications
- RNA modifications and cancer
- Colorectal Cancer Surgical Treatments
- Prostate Cancer Treatment and Research
- CAR-T cell therapy research
- Neuroendocrine Tumor Research Advances
- Plant Stress Responses and Tolerance
- Immunotherapy and Immune Responses
- Plant nutrient uptake and metabolism
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Wireless Body Area Networks
- Ionosphere and magnetosphere dynamics
- ECG Monitoring and Analysis
- Colorectal Cancer Treatments and Studies
- Healthcare Technology and Patient Monitoring
- Radio Astronomy Observations and Technology
- Chemokine receptors and signaling
- Gastrointestinal Tumor Research and Treatment
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2023
Academy of Medical Sciences
2021-2023
Peking Union Medical College Hospital
2021-2022
National Clinical Research
2021
Weatherford College
2021
Fujian Agriculture and Forestry University
2019-2020
Yangtze University
2020
Chinese PLA General Hospital
2016-2017
Nankai University
2016
Signet ring cell carcinoma (SRCC) has specific oncogenesis and phenotypic treatment resistance heterogeneity. Systemic therapies are often ineffective, predictive biomarkers to guide urgently needed. Tumor organoids have recently emerged as an ideal model for drug testing screening. Here, we report gastric established from tumor tissues comprising four SRCCs eight non-SRCCs. demonstrated different growth characteristics morphologies. Changes in the original genome were maintained during...
Abstract Mrk 501 is a prototypical high-synchrotron-peaked blazar and serves as one of the primary targets for Imaging X-ray Polarimetry Explorer (IXPE). In this study, we report polarization measurements based on six IXPE observations. The detection at confidence level exceeding 99% achieved in four out observations conducted across entire energy range (2–8 keV) IXPE. maximum degree (Π X ) measured to be 15.8% ± 2.8%, accompanied by angle ( ψ 98.°0 5.°1 5.6 σ . During remaining two...
Remote ECG monitoring systems are becoming commonplace medical devices for remote heart monitoring. In recent years, have been applied in the of various kinds diseases, and quality transmission reception signals during process kept advancing. However, there remains accompanying challenges. This report focuses on three components system: patient (the end user), doctor workstation, server, reviewing evaluating imminent challenges wearable systems, packet loss transmission, portable system,...
BackgroundProstate-specific antigen (PSA) testing is limited in identifying prostate cancer (PCa) with modestly elevated PSA levels. Therefore, a robust method for the diagnosis of PCa urgently needed.MethodsA total 203 men level ≥4 ng/ml were eligible enrollment this study from July 2018 to May 2021, and randomly divided into training set (n=78) validation (n=125). Circulating tumor cells (CTCs) detected using telomerase-based CTC detection (TBCD), diagnostic ability was evaluated receiver...
Activated Cdc42-associated kinase 1 (ACK1), a kind of tyrosine kinase, is considered to be an oncogene in many cancers, and it likely become potential target for cancer treatment. We found that the expression ACK1 gene colon was higher than normal tissues adjacent cancer, high associated with poor prognosis patients. assessed based on ACK1-related genes constructed model can predict patients data from The Cancer Genome Atlas (TCGA) database. then explored relationship between immune...
Osteosarcoma is a common primary malignant bone cancer. Long noncoding RNA small nucleolar host gene 15 (SNHG15) has been reported to play an oncogenic role in many cancers. Nevertheless, the of SNHG15 doxorubicin (DXR) resistance osteosarcoma cells not fully addressed.Cell Counting Kit-8 assay was conducted measure half-maximal inhibitory concentration value DXR cells. Western blotting carried out examine levels autophagy-related proteins and GDNF family receptor alpha-1 (GFRA1)....
Inositol polyphosphate 5-phosphatases (5PTases) function in inositol signaling by regulating the catabolism of phosphoinositol derivatives. Previous reports showed that 5PTases play a critical role plant development and stress responses. In this study, we identified novel 5PTase gene, Gs5PTase8, from salt-tolerance locus chromosome 3 wild soybean (Glycine soja). Gs5PTase8 is highly up-regulated under salt treatment. It localized nucleus plasma membrane with strong signal apoplast. Ectopic...
Background: Whether circulating tumor cells (CTCs) with prostate-specific membrane antigen (PSMA) high expression was related to the metastatic progress in prostate cancer (PCa) remains explored. This study aimed provide evidence elucidate this relationship via telomerase reverse transcriptase (TERT)-based CTC detection method. Methods: A total of 71 patients were enrolled and divided into local PCa group (n=44) (n=27). TERT-based (TBCD) used detect CTCs. CTCs single-cell sequencing data...
Rationale: Oncolytic virus (OV) therapy as a cancer that improves immune status makes it favorable candidate for optimizing immunotherapy strategies.Existing studies have focused on characterizing the disturbance of tumor microenvironment (TME) by OV therapy.However, changes in systemic immunity induced were largely ignored, which would prevent further understanding and optimization oncolytic viruses.Methods: The HSV-2-based OH2 was used to treat tumor-bearing mouse models.The peripheral...
Abstract Background The combination of oncolytic viruses (OVs) with immune checkpoint blockades is a research hotspot and has shown good efficacy. Here, we present the first attempt to combine herpes simplex virus 2 (OH2) an anti-SIRPα antibody as antitumour treatment. Our results provide unique insight into innate immunity OV. Methods We verified polarization activation OH2 in RAW264.7 cells vitro. Subsequently, evaluated ability combined therapy tumour-bearing mouse model. RNA-seq...
Mrk 501 is a prototypical high-synchrotron-peaked blazar (HBL) and serves as one of the primary targets for Imaging X-ray Polarimetry Explorer (IXPE). In this study, we report polarization measurements based on six IXPE observations. The $>99\%$ confidence detection obtained in four out observations entire energy band (2--8 keV) IXPE, with maximum degree ($\Pi_{\rm X}$) $15.8\%\pm2.8\%$ angle ($\psi_{\rm $98.0^{\circ}\pm5.1^{\circ}$ at level $5.2\sigma$. During other two observations, source...
The role of chemokines in predicting the prognosis colon cancer has not been mentioned. Chemokines have shown to be associated with immune cell chemotaxis and activation, so expression chemokine genes tumor tissue may related prognosis. We used a least absolute shrinkage selection operator (LASSO) model based on gene families construct that can predict patients. divided patients into high-risk groups low-risk study Then, we evaluated relationship between different risk infiltration cells. It...
Abstract Purpose To assess the prognostic value of O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in patients with extensive-stage small-cell lung cancer (ES-SCLC) treated etoposide plus platinum chemotherapy. Methods A prospective single arm cohort study was performed a tertiary teaching hospital China. The rate MGMT detected by quantitative specific PCR (qMS-PCR) assay before Primary endpoint tumor response to chemotherapy according Response Evaluation Criteria Solid...
Objective: The article is to investigate the relationship between polymorphism of transcription factor 7-like 2 (TCF7L2) gene rs7903146 and type diabetes mellitus with obesity in Chinese Han population. Methods: 216 patients (T2DM), 92 males, 124 females, 194 normal controls, 89 males 105 females. TCF7L2 was measured by PCR-RFLP. PCR amplifier used for amplification reaction, followed analysis gene: reaction system 20 μl, among which restriction endonuclease 0.5 μl product 7.5 μl....
Abstract Circulating tumor cell (CTC) clusters possess a much higher capability to seed metastasis than single CTCs. However, the mechanism underlying this phenomenon is still elusive and no reports have investigated role of posttranscriptional RNA regulation in CTC clusters. Here, we compared alternative splicing (AS) polyadenylation (APA) profiles between CTCs 994 836 AS events were identified clusters, separately. About ~20% exhibited alterations both types. The differential SRSF6 was...