A5034590899- Cancer Cells and Metastasis
- Virus-based gene therapy research
- Bladder and Urothelial Cancer Treatments
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- CAR-T cell therapy research
- RNA Research and Splicing
- Nanoplatforms for cancer theranostics
- Cancer Genomics and Diagnostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA Interference and Gene Delivery
- Gastrointestinal Tumor Research and Treatment
- Pharmaceutical Economics and Policy
- Tuberculosis Research and Epidemiology
- Health Systems, Economic Evaluations, Quality of Life
- Innovative Microfluidic and Catalytic Techniques Innovation
- Prostate Cancer Treatment and Research
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- RNA and protein synthesis mechanisms
- 3D Printing in Biomedical Research
- Immunotherapy and Immune Responses
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Peking Union Medical College Hospital
2021-2022
Academy of Medical Sciences
2021
National Clinical Research
2021
Weatherford College
2021
Signet ring cell carcinoma (SRCC) has specific oncogenesis and phenotypic treatment resistance heterogeneity. Systemic therapies are often ineffective, predictive biomarkers to guide urgently needed. Tumor organoids have recently emerged as an ideal model for drug testing screening. Here, we report gastric established from tumor tissues comprising four SRCCs eight non-SRCCs. demonstrated different growth characteristics morphologies. Changes in the original genome were maintained during...
Abstract In recent years, the three‐dimensional (3D) culture system has emerged as a promising preclinical model for tumor research owing to its ability replicate tissue structure and molecular characteristics of solid tumors in vivo. This offers several advantages, including high throughput, efficiency, retention heterogeneity. Traditional Matrigel‐submerged organoid cultures primarily support long‐term proliferation epithelial cells. One solution exploration microenvironment is...
Background: Whether circulating tumor cells (CTCs) with prostate-specific membrane antigen (PSMA) high expression was related to the metastatic progress in prostate cancer (PCa) remains explored. This study aimed provide evidence elucidate this relationship via telomerase reverse transcriptase (TERT)-based CTC detection method. Methods: A total of 71 patients were enrolled and divided into local PCa group (n=44) (n=27). TERT-based (TBCD) used detect CTCs. CTCs single-cell sequencing data...
Rationale: Oncolytic virus (OV) therapy as a cancer that improves immune status makes it favorable candidate for optimizing immunotherapy strategies.Existing studies have focused on characterizing the disturbance of tumor microenvironment (TME) by OV therapy.However, changes in systemic immunity induced were largely ignored, which would prevent further understanding and optimization oncolytic viruses.Methods: The HSV-2-based OH2 was used to treat tumor-bearing mouse models.The peripheral...
Abstract Background The combination of oncolytic viruses (OVs) with immune checkpoint blockades is a research hotspot and has shown good efficacy. Here, we present the first attempt to combine herpes simplex virus 2 (OH2) an anti-SIRPα antibody as antitumour treatment. Our results provide unique insight into innate immunity OV. Methods We verified polarization activation OH2 in RAW264.7 cells vitro. Subsequently, evaluated ability combined therapy tumour-bearing mouse model. RNA-seq...
659 Background: Cisplatin-based chemotherapy is the recommended therapy for muscle-invasive bladder cancer (MIBC), in neoadjuvant setting. However, efficacy of MIBC only about 40%. Therefore, predictors response are urgently needed. Neutrophils form neutrophil extracellular traps (NETs), a network structure, and growing evidence indicated that it could be prognostic predictive marker cancer. Besides, NETs IgG reflect immune response, even may induce tolerance. In MIBC, role or resistance...
You have accessJournal of UrologyBladder Cancer: Invasive V (MP53)1 May 2024MP53-12 PREDICTIVE ROLES OF NETS AND IGG IN NEOADJUVANT CHEMOTHERAPY FOR MUSCLE-INVASIVE BLADDER CANCER Bingqing Shang, Ruiyang Xie, Honglei Cui, Zhaoru Gu, Jie Wu, Aiping Zhou, Hongzhe Shi, and Jianzhong Shou ShangBingqing Shang , XieRuiyang Xie CuiHonglei Cui GuZhaoru Gu WuJie Wu ZhouAiping Zhou ShiHongzhe Shi ShouJianzhong View All Author Informationhttps://doi.org/10.1097/01.JU.0001008784.37684.bd.12AboutPDF...
e16600 Background: Cisplatin-based chemotherapy is the recommended therapy for muscle-invasive bladder cancer (MIBC), in both neoadjuvant and first-line settings. However, efficacy of MIBC only about 40%~60%. Patients without clear benefits from cisplatin-based still suffer potential toxicity, possibly missing timing other effective treatments. Therefore, predictors response are urgently needed. Neutrophils form neutrophil extracellular traps (NETs), a network structure, growing evidence...
Abstract Circulating tumor cell (CTC) clusters possess a much higher capability to seed metastasis than single CTCs. However, the mechanism underlying this phenomenon is still elusive and no reports have investigated role of posttranscriptional RNA regulation in CTC clusters. Here, we compared alternative splicing (AS) polyadenylation (APA) profiles between CTCs 994 836 AS events were identified clusters, separately. About ~20% exhibited alterations both types. The differential SRSF6 was...