A5068876688- Geological and Geochemical Analysis
- Nanopore and Nanochannel Transport Studies
- Fluid Dynamics and Thin Films
- Fluid Dynamics and Heat Transfer
- Fluid Dynamics and Turbulent Flows
- earthquake and tectonic studies
- High-pressure geophysics and materials
- Geochemistry and Geologic Mapping
- Lattice Boltzmann Simulation Studies
- Surface Modification and Superhydrophobicity
- Electrostatics and Colloid Interactions
- Geological and Geophysical Studies
- Microfluidic and Bio-sensing Technologies
- Computational Fluid Dynamics and Aerodynamics
- Blood properties and coagulation
- Hedgehog Signaling Pathway Studies
- Model Reduction and Neural Networks
- Hydrocarbon exploration and reservoir analysis
- Carbon Nanotubes in Composites
- Paleontology and Stratigraphy of Fossils
- Geotechnical Engineering and Soil Stabilization
- Particle Dynamics in Fluid Flows
- Cellular Mechanics and Interactions
- Geochemistry and Elemental Analysis
- Epigenetics and DNA Methylation
Jiangxi Institute Of Economic Administraors
2025
Shanghai University
2013-2024
Ministry of Natural Resources
2021-2024
Chinese Academy of Geological Sciences
2014-2024
Wuhan University of Technology
2007-2024
Ministry of Civil Affairs
2021-2024
China Geological Survey
2022-2023
University of Electronic Science and Technology of China
2023
North China Electric Power University
2021-2022
Nanchang University
2015-2021
Forkhead box M1 (FOXM1) is a proliferation-associated transcription factor of the forkhead proteins superfamily, which includes four isoforms FOXM1a, b, c, and d. FOXM1 has been implicated in hepatocellular carcinoma (HCC) progression, but underlying molecular mechanism remains elusive. In this study, we aim to clarify basis for FOXM1-mediated HCC progression. Bioinformatic analysis was used explore differentially expressed genes predicting proliferation. The expression kinesin family member...
It is of both fundamental and practical interest to study the flow physics in manipulation droplets. In this paper, we investigate complex liquid droplets actuated by a linear gradient wettability using dissipative particle dynamics simulation. The wetting property substrate ranging from hydrophilic hydrophobic achieved adjusting conservative solid-liquid interactions which results variation surface tension. internal three-dimensional velocity field with transverse droplet revealed analyzed...
In order to study the mechanism and effect of basalt fiber reinforced clay soil, a series unconfined compressive strength tests conducted on soil with have been performed under condition optimum water content maximum dry density. Both length are considered in this paper. When is studied, 12 mm long fibers dispersed into at different contents 0.05%, 0.1%, 0.15%, 0.20%, 0.25%, 0.30%, 0.35%. researched, lengths 4 mm, 8 15 put same 0.05%. Experimental results show that can effectively improve...
Cancer develops and progresses often by inactivating p53. Here, we unveil nerve growth factor receptor (NGFR, p75NTR or CD271) as a novel p53 inactivator. activates NGFR transcription, whereas inactivates promoting its MDM2-mediated ubiquitin-dependent proteolysis directly binding to central DNA domain preventing DNA-binding activity. Inversely, ablation p53, consequently inducing apoptosis, attenuating survival, reducing clonogenic capability of cancer cells, well sensitizing human cells...
Recent evidence suggests that the aberrant activation of Hedgehog (Hh) signaling by Gli transcription factors is characteristic a variety aggressive human carcinomas, including colorectal cancer (CRC). Forkhead box M1 (FoxM1) controls expression number cell cycle regulatory proteins, and FoxM1 elevated in broad range malignancies, which it plays crucial role tumorigenesis. However, mechanisms underlying are not fully understood. Here, we aim to further investigate molecular mechanism Gli1...
Phanerozoic large igneous provinces (LIPs) have a significant influence on global climate changes and mass extinction events (MEEs). Most of the Global Boundary Stratotype Section Points in international chronostratigraphic scale are coeval with LIPs marked sedimentary record by global-scale MEEs and/or ocean anoxic represented black shales. However, due to limited knowledge atmospheric oxygen concentrations, redox conditions, early fossils during Meso-Neoproterozoic Eras prior Ediacaran...
Molecular dynamics simulation is utilized to investigate the ionic transport of NaCl in solution through a graphene nanopore under an applied electric field. Results show formation concentration polarization layers vicinity sheet. The non-uniformity ion distribution gives rise pressure which drives vortical motions fluid if field sufficiently strong overcome influence viscosity and thermal fluctuations. relative importance hydrodynamic fluctuations determining pore conductivity investigated....
Shanxi Province, an important source of coal resources in China, has consumed a large amount fossil fuels the past few decades. The CO2 emissions Province have been increasing annually, reaching 541.8 million tons 2018, 54.6% higher than national mean. This will negative impact on China’s ability to meet its target peaking by 2030. To assist China achieve this and reduce study used Long-range Energy Alternatives Planning (LEAP) model analyze peaks from 2019 2035 under different scenarios....
Abstract Landslides are a typical geological disaster, often causing significant damage to agriculture, industrial production, human life, and property, sometimes leading catastrophic outcomes. This study uses the data from Bazimen landslide in Three Gorges area, along with hydrometeorological data. Five machine learning models—Transformer, Random Forest (RF), Backpropagation Neural Network (BP), Decision Tree (DT), Support Vector Regression (SVR)—are employed for displacement prediction....
Continuum simulation is employed to study ion transport and fluid flow through a nanopore in solid-state membrane under an applied potential drop. The results show the existence of concentration polarization layers on surfaces membrane. nonuniformity ionic distribution gives rise electric pressure that drives vortical motion fluid. There also net hydrodynamic due asymmetry induced by surface charge. qualitative behavior similar observed previous using molecular dynamic simulations....
Abstract Background Aberrant activation of the Hedgehog (Hh) signaling pathway is frequently observed in hepatocellular carcinoma (HCC), nevertheless, precise molecular mechanism remains unclear. Forkhead box M1 (FOXM1), a target Hh pathway, key oncofetal transcription factor and master cell cycle regulator. Targeting protein for Xenopus kinesin-like 2 (TPX2) an oncogene critical mitosis. However, how these events affect HCC progression Methods Realtime PCR, immunohistochemistry, western...
Comparisons of large igneous provinces (LIPs) and black shales from different cratons can provide important constraints on Precambrian paleogeographic reconstructions a better understanding the environmental effects large-scale volcanic events. A comparison intraplate mafic events mostly interpreted as LIPs or portions (LIP fragments/remnants due to continental breakup erosion) North China Craton (NCC) Australian (NAC) shows good correlation in age range 1800 Ma 1300 Ma, four robust matches...
Micro-bubbles and bubbly flows are widely observed applied in chemical engineering, medicine, involves deformation, rupture, collision of bubbles, phase mixture, etc. We study bubble dynamics by setting up two numerical simulation cases: flow with a single multiple both confined the microchannel, parameters corresponding to their medical backgrounds. Both cases have background applications. Multiphase requires high computation accuracy due possible component losses that may be caused sparse...
Efficient prediction and evaluation of noise performance are crucial to the design optimization landing gear noise. A systematic method is developed predict evaluate in present study, termed as spectrum deep learning model (NSDL). In this algorithm, encoder decoder designed extract features reconstruct data. Specifically, a loss function that takes identification both broadband tone into account utilized guide training direction model, aiming improve efficiency results model. Afterward,...
A low-dimensional Galerkin method, initiated by Noack and Eckelmann [Physica D 56, 151 (1992)], for the prediction of flow field around a stationary two-dimensional circular cylinder in uniform stream at low Reynolds number is generalized to case rotating translating cylinder. The Hopf bifurcation describing transition from steady time-periodic solution investigated. curve indicating transitional boundary given parameter plane Re α. Our results show that rotation may delay onset vortex...
The collapse of the bubble induced by shock wave leads to nano-jet, which is able perforate cellular membranes. This phenomenon investigated Martini coarse-grained molecular dynamic (CG-MD) simulations in present study. It found that occurrence cavitation nucleation at nanoscale can be observed during perforation process. locates near puncture cell membrane and its ultimate evolutionary form presents a ring-like structure. volume calculated for different initial sizes, it maximum area has...