A5017439293- Metabolism and Genetic Disorders
- Amino Acid Enzymes and Metabolism
- Biochemical and Molecular Research
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Analytical Methods in Pharmaceuticals
- Autophagy in Disease and Therapy
- Analytical Chemistry and Chromatography
- Diabetes Treatment and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neonatal Health and Biochemistry
- Neonatal Respiratory Health Research
- Genomics and Rare Diseases
- Polymer Surface Interaction Studies
- Antimicrobial agents and applications
- LGBTQ Health, Identity, and Policy
- Peroxisome Proliferator-Activated Receptors
- Bone and Joint Diseases
- ATP Synthase and ATPases Research
- Renal function and acid-base balance
- E-Learning and Knowledge Management
- Pancreatic function and diabetes
- COVID-19 epidemiological studies
- Advanced Mathematical Identities
Sardarkrushinagar Dantiwada Agricultural University
2019-2025
Gujarat Technological University
2021-2025
University Hospitals of Cleveland
2024
Case Western Reserve University
2024
Index Medical College, Hospital & Research Centre
2023-2024
Institute of Medical Sciences
2024
Charotar University of Science and Technology
2020-2023
MUSC Hollings Cancer Center
2023
Medical University of South Carolina
2021-2023
Sankalchand Patel University
2023
Pancreatic cancer is characterized by abundant desmoplasia, a dense stroma composed of extra-cellular and cellular components, with associated fibroblasts (CAFs) being the major component. However, tissue(s) origin for CAFs remains controversial. Here we determine tissue pancreatic through comprehensive lineage tracing studies in mice. We find that splanchnic mesenchyme, fetal cell layer surrounding endoderm from which epithelium originates, gives rise to majority resident normal pancreas....
For transgender individuals taking hormone therapy (HT), data on laboratory values are limited, and the effects cannot be easily predicted. We evaluated impact common analytes in before after initiation of HT.We conducted a retrospective chart review patients identified at transgender-specific clinics an urban county hospital community clinic. Laboratory were collected concentrations, hematologic parameters, electrolytes, lipids, liver renal markers 183 women (TW) 119 men (TM) for whom...
Short bowel syndrome is an acquired condition in which the length of small intestine insufficient to perform its normal absorptive function. Current therapies are limited as developmental mechanisms that normally regulate elongation poorly understood. Here, we identify Fgf9 important epithelial-to-mesenchymal signal required for proper intestinal morphogenesis. Mouse embryos lack either or mesenchymal receptors contained a disproportionately shortened intestine, decreased proliferation,...
The present finding provides insight into the different chemistry, morphologies and properties of designed polydopamine films with controlled antibacterial/antifouling properties.
ABSTRACT CASP4/caspase-11-dependent inflammasome activation is important for the clearance of various Gram-negative bacteria entering host cytosol. Additionally, CASP4 modulates actin cytoskeleton to promote maturation phagosomes harboring intracellular pathogens such as Legionella pneumophila but not those enclosing nonpathogenic bacteria. Nevertheless, this non-inflammatory role regarding trafficking vacuolar remains poorly understood. Macroautophagy/autophagy, a catabolic process within...
Result: The developed method was optimized with the help of response surface methodology such as BBD design in expert software. This proposed validated per ICH Q2 recommendation. With a correlation coefficient 0.9935, technique demonstrated linearity having 25-150 µg/mL concentration. Less than 2% RSD reported for precision, while 99.81 - 99.95 % found accuracy. Conclusion: It is possible to effectively use HPLC routine analysis Evogliptin tartrate tablet form since it straightforward,...
A field experiment was conducted during two consecutive years of 2022 and 2023 at Agronomy Instructional Farm, Department Agronomy, Chimanbhai Patel College Agriculture, Sardarkrushinagar Dantiwada Agricultural University, to study the effect PROM, sulphur iron on nutrient content uptake by groundnut. There were twenty-seven treatment combinations comprising each three levels PROM (i.e., 125, 250 375 kg PROM/ha), 12.5, 25.0 37.5 sulphur/ha) 2.0, 4.0 6.0 iron/ha) tested in a randomized block...
Objective: A unique liquid chromatography-tendon mass spectrometric tech-nique for the determination of metformin and vildagliptin in K3EDTA human plasma was developed verified as per USFDA guidelines bioanalysis. Methods: The chromatographic separation achieved using a Cosmosil CN (150 x 4.6mm, 5μm) column with an isocratic elution pattern 10 mM ammonium formate (pH 5.0) methanol ratio 30:70 v/v mobile phase. spectrometer coupled electrospray ionization (ESI) source operating positive ion...
Objectives: The QbD approach validates the formulation during development, ensuring therapeutic benefits through careful selection of herbal extracts. Methods: Oral dosage forms, especially fast dissolving tablets with different extracts (curcumin, saffron, and gingerol) were developed to get their desired actions immediately. Quality by Design (QbD) emphasizes a science-based product development. Experiments (DOE) ANOVA are used analyze high-risk Critical Attributes (CQAs). Expert software...
Abstract Introduction The Preschool Life Impact Burn Recovery Evaluation (PS- LIBRE1-5) is a well-established psychometrically sound Computer Adaptive Test (CAT). Short forms (SF) were developed for dissemination in environments where platforms administering CATs are not available. aim of the present study to assess reliability PS-LIBRE1-5 SFs within target population preschool children, 1 5 years, living with burn injuries. Methods There eight domains; Physical Functioning, Communication...
Abstract Introduction Adolescents undergo major development and social changes. However, coupling adolescence with burn injuries can complicate interactions relationships. The Teen-Aged Life Impact Burn Recovery Evaluation (TA-LIBRE12-19) is being developed as a burn- age-specific outcome metric. Using the World Health Organization’s International Classification for Functioning, Disability, Children Youth, alongside comprehensive literature review, conceptual framework was developed. Two...
Abstract Background A quality by design approach can potentially lead to a more robust/rugged method development due emphasis on the risk assessment and management. By carefully understanding step-by-step procedure for analytical QbD-based optimization parameters, such as target profile critical attributes (CQAs), was assessed. The present study describes simple, rapid, sensitive cost-effective RP-HPLC validation estimation of evogliptin tartrate in pharmaceutical dosage form. Results factor...
A novel mechanism was developed to study the interaction of mussel inspired polydopamine surfaces with bovine serum albumin using electrochemical impedance spectroscopy.
Abstract Amino acid analysis is central to newborn screening and the investigation of inborn errors metabolism. Ion‐exchange chromatography with ninhydrin derivatization remains reference method for quantitative amino but offers slow susceptible interference from other co‐eluting compounds. Liquid‐chromatography tandem mass spectrometry (LC‐MS/MS) provides a rapid highly specific alternative, sample preparation frequently laborious sometimes cost prohibitive. To address these limitations, we...
Quinoxaline is a versatile heterocyclic moiety that possesses wide range of biological activities. Therefore, many researchers have been performing the synthesis quinoxaline derivatives on daily basis. In addition, high demands for their often result in an increased generation different waste chemicals. However, to minimize utilization and toxic organic substances, present review focuses various green synthetic approaches its derivatives. Moreover, due quick manufacturing novel medications...
A new simple stability indicating reverse phase liquid chromatography method was developed by employing Quality Design (QbD) approach for the simultaneous determination of Linagliptin and Metformin HCl. Within QbD paradigm, present study aimed to establish optimization RP-HPLC (Reverse high performance chromatography) means design experiments response surface mythology like, Centre composite (CCD) in order achieve a good separation resolution. The is effective separate HCl with...
Abstract:: The benzimidazole and its derivatives are privileged heterocyclic motif important building block for the development of biologically active compound. However, several research reports produced in a short period time due to rapid production new drugs having nucleus. In order understand current status nucleus medicinal chemistry science, it is therefore combine latest knowledge with earlier information. Hence, synthetic organic chemists concentrated on inventing an effective green...