A5103211507- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Pesticide Residue Analysis and Safety
- Advanced Drug Delivery Systems
- Analytical Chemistry and Sensors
- Computational Drug Discovery Methods
- Drug Solubulity and Delivery Systems
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Medicinal Plants
- Pharmacological Effects and Assays
- Advancements in Transdermal Drug Delivery
- Synthesis and biological activity
- Antibiotics Pharmacokinetics and Efficacy
- Biosimilars and Bioanalytical Methods
- Inflammatory mediators and NSAID effects
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Medicinal Plants and Neuroprotection
- Pharmaceutical Economics and Policy
- Pharmaceutical Practices and Patient Outcomes
- Pharmacological Effects of Medicinal Plants
- Ginseng Biological Effects and Applications
- HIV/AIDS drug development and treatment
- Piperaceae Chemical and Biological Studies
- Chromatography in Natural Products
Charotar University of Science and Technology
2022-2025
United States Food and Drug Administration
2021
Kadi Sarva Vishwavidyalaya
2012-2019
Shreemati Nathibai Damodar Thackersey Women's University
2011
Active vaccination of elderly Alzheimer's disease (AD) patients with fibrillar amyloid-β peptide (Aβ 42 ), even in the presence a potent Th1 adjuvant, induced generally low titers antibodies small fraction (∼20% responders) those that received AN-1792 vaccine. To improve immunogenicity and reduce likelihood inducing adverse autoreactive T-cells specific for Aβ , we previously tested wild-type mice an alternative approach active immunization: epitope vaccine selectively initiate B cell...
Objective: A unique liquid chromatography-tendon mass spectrometric tech-nique for the determination of metformin and vildagliptin in K3EDTA human plasma was developed verified as per USFDA guidelines bioanalysis. Methods: The chromatographic separation achieved using a Cosmosil CN (150 x 4.6mm, 5μm) column with an isocratic elution pattern 10 mM ammonium formate (pH 5.0) methanol ratio 30:70 v/v mobile phase. spectrometer coupled electrospray ionization (ESI) source operating positive ion...
An accurate, simple, reproducible, and sensitive HPLC method was developed validated for the simultaneous determination of atorvastatin calcium, ezetimibe, fenofibrate in a tablet formulation. The analyses were performed on an RP C18 column, 150 x 4.60 mm id, 5 pm particle size. mobile phase methanol-acetonitrile-water (76 + 13 11, v/v/v), pumped at constant flow rate 1 mL/min. UV detection 253 nm. Retention times found to be 2.25, 3.68, 6.41 min, respectively. terms linearity, precision,...
The solid-self nanoemulsifying drug delivery system (S-SNEDDS) of Amiodarone hydrochloride (AH) was prepared and evaluated. AH exhibits poor aqueous solubility (0.3-0.5 mg/ml) therefore variable oral bioavailability. Capmul MCM, Cremophor RH-40 Propylene glycol were identified as oil, surfactant co-surfactant for preparing L-SNEDDS. D-optimal design used to optimize the amount components in liquid self (L-SNEDDS). Optimized AH-L-SNEDDS having 15.8 nm globule size 99.5 %transmittance then...
Fluocinolone acetonide is a steroidal drug and Miconazole nitrate an antifungal azole. The combination of these drugs has highly beneficial effect on dermatological inflamatory disorders associated with fungal infections. A simple, specific, accurate, precise, robust stability indicating HPTLC method been developed validated for the simultaneous estimation in bulk ointment dosage form. Chromatography was performed using pre-coated silica gel aluminium plate 60F254, (10 ×10 cm) as stationary...
A simple, sensitive HPTLC method has been developed and validated for the simultaneous estimation of atorvastatin calcium, ezetimibe, fenofibrate in tablet dosage form. Chromatographic separation was performed on aluminum plates precoated with silica gel 60 F254 toluene:chloroform:methanol:glacial acetic acid (4.6:3:1.4:0.1, v/v/v/v) as mobile phase. The drugs were well resolved RF values 0.20 ± 0.01, 0.33 0.80 0.02 fenofibrate, respectively. Densitometric evaluation separated zones at 253...
Background: Vitex negundo (Nagod) is a very useful medicinal plant growing throughout India. The leaves of Nagod are aromatic, tonic and vermifuge. They in the treatment many ailments. Introduction: Both seasonal geographical variations have been observed active constituents negundo. A comprehensive reproducible HPLC method based on fingerprint analysis was developed for assessing quality Methods: Sixteen samples collected from different locations seasons India were analysed by chromatograms...
Doxepin hydrochloride (DOX) is a tricyclic antidepressant drug. Three sensitive spectrofluorimetric methods, namely resonance Rayleigh scattering (RRS), frequency doubling (FDS) and second-order (SOS), were developed validated for their estimation of doxepin in spiked human plasma formulation using liquid-liquid extraction method through the formation an ion pair complex with eosin Y at pH 4.5. Various factors affecting fluorescence intensity optimized, reaction kinetics was determined...
Introduction: The stereochemical characteristics of spirofused and their derivatives have recently attracted a great deal interest in synthetic organic chemistry. Methods: A series ecologically acceptable heterocycle compounds S(K1–K8) were made using one- pot microwave irradiation characterized by FTIR, 1HNMR, Mass Spectroscopy. Iodine-catalyzed Biginelli-type condensation process has been used to synthesize novel anti-microbial anthelmintic potential spiroketals (spirofused) fast, safe...
Abstract Background: Ayurvedic medicines help in healing disease with fewer undesirable effects comparison an allopathic system of medicine to treat central nervous (CNS) disorders, as the latter is more expensive. Centella asiatica L. often used formulations for treatment CNS disorders. Objective: A stability test using HPTLC method estimation important marker asiaticoside (ASI) from C. powder and marketed formulation was developed. Methods: The compound ASI plant powders were resolved...
Abstract Background Jatyadi taila (JT) is a well-known Ayurvedic wound-healing product, comprising 16 different medicinally important plants, including Curcuma longa, Terminalia chebula, and Jasminum officinale. Objective The proposed work discusses the development validation of green economical stability-indicating HPTLC method for quantification key marker phytoconstituents, curcumin (CUR), gallic acid (GA), ursolic (UA), from JT. Method Quality standard parameters JT were determined...