Alkesh Patel

ORCID: 0000-0001-7036-5011
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Research Areas
  • Computational Drug Discovery Methods
  • Topic Modeling
  • Speech and dialogue systems
  • Monoclonal and Polyclonal Antibodies Research
  • HER2/EGFR in Cancer Research
  • Natural Language Processing Techniques
  • Gas Sensing Nanomaterials and Sensors
  • Advanced Drug Delivery Systems
  • Wound Healing and Treatments
  • Phytochemicals and Medicinal Plants
  • Cancer Cells and Metastasis
  • Cancer Research and Treatments
  • Multimodal Machine Learning Applications
  • AI in Service Interactions
  • Immunotherapy and Immune Responses
  • Vitamin C and Antioxidants Research
  • Nanoparticle-Based Drug Delivery
  • Colorectal Cancer Treatments and Studies
  • RNA Interference and Gene Delivery
  • Diabetic Foot Ulcer Assessment and Management
  • Pressure Ulcer Prevention and Management
  • Molecular Communication and Nanonetworks
  • Pigment Synthesis and Properties
  • Medicinal Plants and Bioactive Compounds
  • ZnO doping and properties

Charotar University of Science and Technology
2018-2025

Apple (Germany)
2023

Royal Marsden Hospital
2023

Post Graduate Institute of Medical Education and Research
2020

Sandip Foundation
2020

World Intellectual Property Organization
2020

The World Academy of Sciences
2020

Mansoura University
2020

Pharmac
2020

Parul University
2017

The prevalence of Parkinson's Disease (PD) is high, and treatment not optimal to date. Curcumin possesses neuroprotective effects. Nevertheless, oral use incommodious due its poor bioavailability. Numerous attempts have been made increase systemic Among these, an effective way the bioavailability curcumin by combining it with probiotics target glucuronidation reaction. present study focuses on bio-enhancement using in animal models PD alleviating oxidative stress ameliorating dopamine...

10.62347/tkqk8110 article EN American Journal of Translational Research 2025-01-01

The present research focuses on formulating and evaluating hydrogels modified with crosslinking agents using methylcellulose to treat diabetic foot ulcers (DFU). Methylcellulose are prepared characterized for their capacity through FTIR degradation studies. optimized hydrogel is further assessed viscosity, gel strength, contact angle, in-vitro biodegradation, water-vapor transmission rate, anti-bacterial activity, in-vivo efficacy. results demonstrate that the developed exhibits promising...

10.1080/09205063.2024.2333068 article EN Journal of Biomaterials Science Polymer Edition 2024-03-27

10.1016/0022-0248(73)90201-7 article EN Journal of Crystal Growth 1973-02-01

Objectives: Chronic renal failure (CRF) is a public health concern in both developed and developing countries. Therefore, there still need to look for secure successful agents that can either minimise or prevent CRF from advancing end-stage disorder. This study aimed assess the effect of lycopene on adenine-induced rat. Materials Methods: Animals were divided into five groups ( n = 6). Normal control group received normal vehicle, disease orally adenine (50 mg/kg/day), L 100 (100 mg/kg/day)...

10.25259/ijpp_188_2020 article EN cc-by-nc-sa Indian Journal of Physiology and Pharmacology 2021-08-09

Abstract: Berberine (BRB) is a natural alkaloid of the isoquinoline class, mostly isolated from Berberis genus, which exhibits antibiotic, immunostimulant, antitumor, cardiovascular protection, endocrine regulator, antidepressant, neuroprotective, antioxidant, anti-inflammatory, and other pharmacological properties. The poor aqueous solubility BRB one roadblock in scaling up activities for clinical drug. However, this can be overcome by its chemical modification into salt form. Extraction...

10.2174/1573412919666230505095457 article EN Current Pharmaceutical Analysis 2023-05-08

Shruti Bhargava, Anand Dhoot, Ing-marie Jonsson, Hoang Long Nguyen, Alkesh Patel, Hong Yu, Vincent Renkens. Proceedings of the 61st Annual Meeting Association for Computational Linguistics (Volume 5: Industry Track). 2023.

10.18653/v1/2023.acl-industry.72 article EN cc-by 2023-01-01

Objective: Investigation of methanolic extract for detecting the presence Betanin by phytochemical analysis, to induce experimental hypertension and carry out measurement BP invasive (direct) method (IBP) vascular reactivity various catecholamines after completion treatment schedule.Methods: The animals were divided into six main groups. Each group contains 5 animals. Group I received vehicle , II dexamethasone injection (20 µg/kg/day, s.c.) 14 days III Beta vulgaris (100 mg/kg/day, p.o.) IV...

10.26510/2394-0859.pbe.2017.06 article EN Pharmaceutical and Biological Evaluations 2017-02-07

The SARS-CoV-2 virus emerged as a major cause of the COVID-19 pandemic in December 2019. Many attempts have been made to block viral infection by targeting various processes like its entry, uncoating, replication, activating T cells response, and rising antibody titer. Also, many drugs are repurposed remdesivir, dexamethasone, tocilizumab, hydroxychloroquine based on their established therapeutic efficacy against other viruses past. Natural products (NP) consist promising candidate needed...

10.25135/acg.oc.97.2012.1895 article EN Organic Communications 2021-03-26

Colorectal cancer (CRC) is the deadliest malignancy in world. The first-line chemotherapy used for CRC 5-fluorouracil (5-FU). 5-FU completely eradicates rapidly proliferating and terminally differentiated tumor cells but fails to target stem (CSCs). As a result, may shrink temporarily, remnant CSC multiplies forms again more aggressively. recurrence resistance lead metastasis.

10.4103/jcrt.jcrt_1299_22 article EN Journal of Cancer Research and Therapeutics 2023-01-01

Background: Colorectal Cancer may occur due to environmental pollutants like polycyclic aromatic hydrocarbons and hydrazines. These are indirect carcinogens initiate carcinogenesis after their metabolic transformation within the body. This causes more than 0.94 million deaths every year. Methods: We investigated prophylactic intervention of hydroalcoholic extract Tinospora cordifoilia stems aqueous Solanum nigrum leaves in 1, 2 dimethyl hydrazine induced colorectal cancer Sprague Dawley...

10.52711/0974-360x.2024.00340 article EN Research Journal of Pharmacy and Technology 2024-05-15

Colorectal cancer (CRC) is the most frequent in developing and developed countries. Chemotherapy acts on a few biomarkers, but CRC develops progresses because of multiple genetic epigenetic dysregulation. The animal study was conducted according to Committee for Purpose Control Supervision Experiments Animals Animal Research: Reporting In Vivo guidelines. induced by 1,2-dimethylhydrazine at 35 mg/kg all Sprague-Dawley male rats 10 weeks except normal control. Later, treatment given 5 with...

10.7324/japs.2024.161574 article EN Journal of Applied Pharmaceutical Science 2024-01-01
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