Abstract: Addressing infectious conditions presents a formidable challenge, primarily due to the escalating issue of bacterial resistance. This, coupled with limited financial resources and stagnant antibiotic research, compounds crisis. Innovative strategies, including novel development alternative solutions, are crucial combat microbial Nanotherapeutics offers promising approach enhance drug delivery systems. Integration into lipid-based nanoscale systems, particularly through therapeutic...

The purpose of this study was to formulate, characterize and conduct in vitro cytotoxicity 5-fluorouracil loaded polymeric electrospun nanofibers for the treatment skin cancer. patents on (US9393216B2), (US14146252), (WO2015003155A1) etc. helped selection polymers method preparation nanofibers.In present study, fabrication done using a blend chitosan with polyvinyl alcohol processed electrospinning technique. known chemotherapeutic potential cancer used as drug carrier. 24-1 fractional...

Over the past decades, comprehensive attempts have been made to improve physiological absorption by designing delivery systems, using suitable carriers, and altering route of administration. Here, vaginal was targeted capsular-shaped biodegradable in situ porous drug-eluting inserts (DEI) clotrimazole as a model drug PCL PEO WSR 303 rate-controlling polymers. Morphology, thermal properties, degradation kinetics were assessed comparison non-porous DEI. The optimized DEI showed site-specific...

The distinct anatomy and physiology of the eye represent it as a specialized organ. noumenal physiological barriers, whose prominent role is to prevent entrance extracellular substances, reduce bioavailability medicines taken locally. Nanocarriers offer many advantages, such site-specific drug delivery, reduced dose-related side effects, more loading capacity, etc. Nanoparticles, nano micelles, Nanostructured Lipid Carriers (NLCs), Solid Nanoparticles (SLNs), liposomes, polymeric...

The present research focuses on formulating and evaluating hydrogels modified with crosslinking agents using methylcellulose to treat diabetic foot ulcers (DFU). Methylcellulose are prepared characterized for their capacity through FTIR degradation studies. optimized hydrogel is further assessed viscosity, gel strength, contact angle, in-vitro biodegradation, water-vapor transmission rate, anti-bacterial activity, in-vivo efficacy. results demonstrate that the developed exhibits promising...

Systemic chemotherapy has been shown to produce side effects. A small fraction of the drug reaches tumor site; other healthy organs or normal tissues get affected damaged due nonspecific action these cytotoxic agents. Furthermore, their short period activity, repeat injections are often required, which can lead exacerbation effects and inconvenience. To overcome obstacles, in this study, we developed controlled targeted intratumoral injection. Hydrogel was prepared by physical cross-linking...

The most common vaginal disorders are within the uterus. According to latest statistics, occur in 50% 60% of females. Although curative treatments rely on surgical therapy, still first-line treatment is a non invasive drug. Conventional therapies available oral and parenteral route, leading nonspecific targeting, which can cause dose-related side effects. Vaginal localized uterine intrauterine delivery via site deemed preferable route mitigate clinical drug limitations.This study emphasizes...

The dressing materials that provide surface protection, bacteriostatic activities, and tissue regeneration are important for the treatment management of complex wounds. This study aimed to evaluate wound-healing properties electrospun nanofibers containing a blend methylcellulose (MC) polyvinyl alcohol (PVA). were tested in single-layered (S-NFs) multilayered (M-NFs) forms (PCL/MC-PVA/PCL). In vitro scratch assay using L929 cells vivo experiments on Wistar rats conducted. results showed both...

Background: The purpose of this study was to formulate, characterize and in-vitro cytotoxicity 5-Fluorouracil loaded controlled release nanoparticles for the treatment skin cancer. patents on (US8414926B1), (US61654404A), (WO2007150075A3) etc. helped in selection polymers method preparation nanoparticles. Methods: In present were prepared by simple ionic gelation using various concentrations chitosan sodium tripolyphosphate (TPP). Several process formulation parameters screened optimized...

Chitosan Nanoparticles (CSNPs), as drug carrier, can be utilized for enhancing permeability of poorly absorbed drugs. The aim this work was to enhance the Ganciclovir (GCV) by loading into CSNPs. An ionic gelation method undertaken develop GCV loaded Several process and formulation parameters were screened optimized through 25-2 fractional factorial design Box-Behnken respectively. CSNPs evaluated characterized their particle size shape, surface charge, entrapment efficiency, crosslinking...

The aim of the present research work was to develop safe, effective, and stable in situ hydrogel for ophthalmic drug delivery using combination ion-responsive polymer gellan gum pH-sensitive carbopol 934P treat glaucoma. Background: Timolol maleate is a BCS class I used as first line treatment open-angle rapid precorneal elimination conventional formulation containing drugs exhibits poor therapeutic effect bioavailability. So, gelling system formulated characterized. Methods: Box-Behnken...

Most drugs used to treat vaginal disorders are administered orally or parenterally.Mifepristone (MFP) is a Biopharmaceutical Classification System class IV drug that currently abort pregnancies under 70 days long.To improve bioavailability, modified liquisolid compact (MLSC) formulation has been proposed for administration off-label treatment of uterine fibroids.The MLSC was prepared using ultrasonication with pre-screened excipients minimize the bulk final and enhance properties commercial...