A5079943588- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Ultrasound Imaging and Elastography
- AI in cancer detection
- Photoacoustic and Ultrasonic Imaging
- Neonatal and Maternal Infections
- Cancer Risks and Factors
- Digital Radiography and Breast Imaging
- Cancer Diagnosis and Treatment
- Cellular Mechanics and Interactions
- Cancer Genomics and Diagnostics
- Force Microscopy Techniques and Applications
- thermodynamics and calorimetric analyses
- Neonatal Health and Biochemistry
- Maternal and fetal healthcare
- Streptococcal Infections and Treatments
- Genetic factors in colorectal cancer
- Maternal and Perinatal Health Interventions
- Pregnancy and preeclampsia studies
- Ectopic Pregnancy Diagnosis and Management
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Treatment and Research
- Global Cancer Incidence and Screening
- Molecular Biology Techniques and Applications
- Reproductive System and Pregnancy
St. Claraspital
2017-2024
University Hospital of Basel
2006-2023
Universitäts Frauenklinik
2005-2016
University of Basel
2007-2012
Hospital Base
2008
Weatherford College
2007
Women's Hospital
2005
Abstract Background Insulin-like growth factor-1 (IGF-I) signalling is important for cancer initiation and progression. Given the emerging evidence role of stroma in these processes, we aimed to characterize effects IGF-I on cells stromal separately. Methods We used an ex vivo culture model measured gene expression changes after stimulation with cDNA microarrays. In vitro data were correlated findings by comparing results published datasets human biopsies. Results Upon IGF-I, breast...
Previous research evaluating the use of adjuvant endocrine therapy among postmenopausal breast cancer patients showed with 15-50% wide ranges non-adherence rates. We evaluated this issue by analysing an unselected study group comprising 325 women, diagnosed from 1997 to 2003 hormonal receptor-positive invasive cancer. The different clinical situations that led discontinuation were clearly defined and differentiated: was not simply act stopping medication, but rather manifestation intentional...
We analyzed circulating cell-free DNA in the serum of patients with benign and malignant breast disease healthy individuals to determine its diagnostic value.Serum samples were obtained from 50 individuals, 33 32 disease. Circulatory was extracted samples. Cell-free quantified by real-time quantitative PCR for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene. Tissue lesions histopathologically examined.The mean levels 41,149 genome equivalents (GE)/mL disease, 30,826 GE/mL 13,267...
Real-time elastography (RTE) is a noninvasive imaging modality where tumor-associated changes in tissue architecture are recognized as increased stiffness of the lesion compared to surrounding normal tissue. In contrast this macroscopic appraisal, quantifying properties at subcellular level by atomic force microscopy (AFM) reveals aggressive cancer cells be soft. We RTE and AFM profiling same breast explore diagnostic potential elasticity different length scales. Patients were recruited from...
Abstract Introduction Gene expression profiling has been successfully used to classify breast cancer into clinically distinct subtypes, and predict the risk of recurrence treatment response. The aim this study was investigate whether gene profile (GEP) detected in a core biopsy (CB) is representative for entire tumor, since CB an important tool diagnosis. Moreover, we investigated performing CBs prior surgical excision could influence GEP respective tumor. Methods We quantified RNA 60...
// Marcus Vetter 1,* , Spyridon Fokas 2,* Ewelina Biskup 3,7 Thomas Schmid 4 Fabienne Schwab 2 Andreas Schoetzau Uwe Güth 5 Christoph Rochlitz 1 and Rosanna Zanetti-Dällenbach 6 Department of Medical Oncology, University Hospital Basel, Switzerland Women’s Hospital,University 3 Internal Medicine, The Royal Marsden Hospital, London, United Kingdom Brust-Zentrum Zurich, Sankt Claraspital, 7 Shanghai Medicine Health Sciences, Basic College, Shanghai, PR China * These authors...
Ultrasound (US) is a well-established diagnostic procedure for breast examination. We investigated the malignancy rate in solid lesions according to their BI-RADS classification with particular focus on false-negative 3 lesions. examined whether patient history and clinical findings could provide additional information that would help determine further steps lesions.We conducted retrospective study by exploring US 1469 of 1201 patients who underwent minimally invasive biopsy (MIBB) from...
The study aimed to improve breast cancer diagnosis with new ultrasound (US) modalities. We examined whether real-time elastography (RTE) complements the diagnostic performance of US.The Ethical Committee approved study. Patients provided written informed consent and received a whole workup. Breast lesions were evaluated by US RTE. Lesions assessed BI-RADS, Tsukuba score (TS) strain ratio (SR).The included 164 which 101 benign 63 malignant. Women predominantly premenopausal sonographic dense...
A 34-year-old woman with a history of appendectomy presented to the ED acute abdominal pain. An intrauterine pregnancy had been diagnosed by her gynecologist. Transvaginal ultrasonography revealed 4-cm right adnexal mass and free fluid in peritoneal cavity.
Objective: To compare the efficacy of vaginal misoprostol versus dinoprostone for induction labor (IOL) in patients with preeclampsia according to WHO criteria.
Abstract Purpose To prospectively compare the diagnostic accuracy of radial breast ultrasound (r-US) to that conventional meander-like (m-US), patients a consecutive, unselected, mixed collective were examined by both scanning methods. Methods Out 1948 dual examinations, 150 revealed suspicious lesions resulting in 168 biopsies taken from 148 patients. Histology confirmed cancers 36 cases. Sensitivity, specificity, accuracy, PPV, and NPV calculated for r-US m-US. The examination times...
This study investigated the effect of an intervention designed to reduce patients' emotional distress associated with breast biopsy.125 biopsy patients receiving standard care (control group, CG) were compared 125 (intervention IG) who received a brochure information prior and biopsied by physicians trained in empathic communication. Anxiety was assessed State-Anxiety Inventory (STAI-S) at four time points (pre- post-procedural, pre- post-histology). All participants completed...