A5070277032- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Radiology practices and education
- Radiation Dose and Imaging
- Photoacoustic and Ultrasonic Imaging
- Neuroblastoma Research and Treatments
- Nanoplatforms for cancer theranostics
- Melanoma and MAPK Pathways
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- HER2/EGFR in Cancer Research
- MRI in cancer diagnosis
- Neuroendocrine Tumor Research Advances
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Optical Coherence Tomography Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pelvic and Acetabular Injuries
- Radioactivity and Radon Measurements
- Simulation-Based Education in Healthcare
- Urinary Bladder and Prostate Research
- Artificial Intelligence in Healthcare and Education
- Reconstructive Surgery and Microvascular Techniques
LMU Klinikum
2018-2025
Ludwig-Maximilians-Universität München
2018-2025
Rensselaer Polytechnic Institute
2025
University of California, San Francisco
2023-2024
University Hospital of Basel
2019-2020
Charité - Universitätsmedizin Berlin
2020
Abstract Background Pseudoprogression (PsPD) is a rare response pattern to immune checkpoint inhibitor (ICI) therapy in oncology. This study aims reveal imaging features of PsPD, and their association other relevant findings. Methods Patients with PsPD who had at least three consecutive cross-sectional studies our comprehensive cancer center were retrospectively analyzed. Treatment was assessed according Response Evaluation Criteria Solid Tumors (iRECIST). defined as the occurrence...
<title>Abstract</title> Background Immune checkpoint inhibitors (ICIs) have emerged as a highly effective treatment option for patients with metastatic melanoma. As not all respond to ICI immunotherapy imaging biomarkers must be used accurately monitor early response therapy. Therefore, the aim of this study was evaluate contrast-enhanced ultrasound (CEUS) VEGFR2-targeted microbubbles monitoring effects combined anti-PD-L1/anti-CTLA-4 in murine melanoma model. Methods Murine allografts...
Background Noniodinated intravenous contrast agents have shown significant potential to improve computed tomography (CT) imaging; however, in vivo evidence for impact on lesion detection remains scarce. Purpose The aim of the study was compare a novel carboxybetaine zwitterionic–coated tantalum oxide (TaCZ) nanoparticle agent clinical iodinated liver tumors rabbit tumor model at CT. Methods Following hepatic implantation VX2 tumors, n = 10 rabbits were repeatedly scanned CT system before and...
Despite well-documented limitations, current guidelines recommend the use of size-based RECIST 1.1 for response assessment gastroenteropancreatic neuroendocrine tumors (GEP-NETs) under radiopharmaceutical therapy (RPT). We hypothesize that functional criteria are superior to and progression-free survival (PFS) prediction, molecular scores can be used in prognosticating PFS. <b>Methods:</b> This single-center, retrospective study included 178 patients with GEP-NETs (G1 G2) who were treated at...
Purpose The aim of this study was to evaluate the impact implementing an artificial intelligence (AI) solution for emergency radiology into clinical routine on physicians' perception and knowledge. Materials Methods A prospective interventional survey performed pre-implementation 3 months post-implementation AI algorithm fracture detection radiographs in late 2022. Radiologists traumatologists were asked about their knowledge a 7-point Likert scale (−3, “strongly disagree”; +3, agree”)....
The recently proposed standardized reporting and data system for somatostatin receptor (SSTR)-targeted PET/CT SSTR-RADS 1.0 showed promising first results in the assessment of diagnosis treatment planning with peptide radionuclide therapy (PRRT) neuroendocrine tumors (NET). This study aimed to determine intra- interreader agreement 1.0.SSTR-PET/CT scans 100 patients were independently evaluated by 4 readers different levels expertise according criteria at 2 time points within 6 weeks. For...
Abstract Background Full‐procedure virtual reality (VR) simulator training in robotic‐assisted radical prostatectomy (RARP) is a new tool surgical education. Methods Description of the development VR RARP simulation model, (RobotiX‐Mentor®) including non‐guided bladder neck (ngBND) and neurovascular bundle dissection (ngNVBD) modules, assessment face, content, construct validation ngBND ngNVBD modules by robotic surgeons with different experience levels. Results Simulator ngBND/ngNVBD were...
The purpose of the study was to investigate a novel BRAF and CDK 4/6 inhibitor combination therapy in murine model BRAF-V600-mutant human melanoma monitored by 18F–FDG-PET/CT diffusion-weighted MRI (DW-MRI). Human (A375) xenograft-bearing balb/c nude mice (n = 21) were imaged DW-MRI before (day 0) after 7) 1-week 12; dabrafenib, 20 mg/kg/d; ribociclib, 100 mg/kg/d) or placebo 9). Animals scanned on small animal PET intravenous administration MBq 18F–FDG. Tumor glucose uptake calculated as...
Abstract Objectives In this multi-center study, we proposed a structured reporting (SR) framework for non-small cell lung cancer (NSCLC) and developed software-assisted tool to automatically translate image-based findings annotations into TNM classifications. The aim of study was validate the SR NSCLC, assess its potential clinical impact in proof-of-concept evaluate current standards participating institutions. Methods A staging NSCLC collaboration. descriptions were used generate...
Zusammenfassung Hintergrund Der Stellenwert künstlicher Intelligenz (KI) hat in der medizinischen Bildgebung den letzten Jahren deutlich zugenommen. Aufgrund enormen Datenmengen und strukturierbaren Aufgaben im diagnostischen Workflow die KI onkologischen Hybridbildgebung besonders vielversprechende Anwendungsgebiete für Läsionsdetektion, Läsionscharakterisierung Therapiebeurteilung. Vor dem rasanter Entwicklungen Bereich des Machine Learning (ML) Deep (DL) ist von einer zunehmenden...
(1) Background: To assess the treatment response of benign prostatic syndrome (BPS) following artery embolization (PAE) using a semi-automatic software analysis magnetic resonance imaging (MRI) features and clinical indexes. (2) Methods: Prospective, monocenter study MRI data n = 27 patients with symptomatic BPS before (1, 6, 12 months) after PAE. was performed dedicated for segmentation central total gland (CG, TG), respectively; signal intensities (SIs) T1-weighted (T1w), T2-weighted...
Zusammenfassung Die Leber kann von verschiedenen Malignomen betroffen sein. Bei gewissen Risikofaktoren steigt die Wahrscheinlichkeit der Entwicklung lebereigenen Tumoren (primären Lebertumoren) an. häufigsten Tumormanifestationen sind allerdings sekundär durch Metastasen bedingt. Zwischen den zur Verfügung stehenden radiologischen Modalitäten bestehen in Detektion und Charakterisierung Leberläsionen relevante Unterschiede. Dabei werden konventioneller kontrastmittelverstärkter Ultraschall...
Purpose To investigate αvβ3-integrin-targeted optoacoustic imaging and MRI for monitoring a BRAF/MEK inhibitor combination therapy in murine model of human melanoma. Materials methods Human BRAF V600E-positive melanoma xenograft (A375)-bearing Balb/c nude mice (n = 10) were imaged before (day 0) after 7) (encorafenib, 1.3 mg/kg/d; binimetinib, 0.6 mg/kg/d, n 5) or placebo 5), respectively. Optoacoustic was performed on preclinical system unenhanced 5 h i. v. injection an fluorescent probe....