A5019572077- Chronic Myeloid Leukemia Treatments
- Eosinophilic Disorders and Syndromes
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Ubiquitin and proteasome pathways
- DNA Repair Mechanisms
- PI3K/AKT/mTOR signaling in cancer
- CRISPR and Genetic Engineering
- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- Reconstructive Surgery and Microvascular Techniques
- Breast Implant and Reconstruction
- Cancer Treatment and Pharmacology
- PARP inhibition in cancer therapy
- Molecular Junctions and Nanostructures
- Genomics, phytochemicals, and oxidative stress
- Advanced Breast Cancer Therapies
- Lymphoma Diagnosis and Treatment
- Platelet Disorders and Treatments
- Multiple Myeloma Research and Treatments
- Organic Chemistry Cycloaddition Reactions
- Peptidase Inhibition and Analysis
- Glycosylation and Glycoproteins Research
- HER2/EGFR in Cancer Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Otto-von-Guericke University Magdeburg
2009-2024
University of Würzburg
1995-2023
Universitätsklinikum Würzburg
2019-2022
Lindenhofspital
2021
Klinik und Poliklinik für Strahlentherapie und Radioonkologie
2021
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2017
University of Freiburg
2010
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2004-2008
Goethe University Frankfurt
2008
Johannes Gutenberg University Mainz
2004-2007
Clonal cytogenetic abnormalities (CCA) were detected in Philadelphia chromosome (Ph)-negative cells some patients with chronic myeloid leukemia (CML) who attained a response to imatinib mesylate. In patients, CCA/Ph-negative status was associated myelodysplasia or acute leukemia. The objective of the current study determine prognostic impact cells.The authors compared pretherapeutic risk factors (Kruskall-Wallis test), exposure cytotoxic drugs (chi-square and overall progression-free...
The overexpression of somatostatin receptor 2 (sst2) in neuroendocrine tumors is the molecular basis for diagnostic and therapeutic application stable analog octreotide. Recent evidence has shown that immunocytochemical evaluation sst2A status value predicting response to octreotide therapy disease prognosis. However, due lack monoclonal limited availability specific polyclonal anti-sst2A antibodies, only very few patients can currently benefit from vitro sst2 evaluation.In present study, we...
Breast reconstruction by latissimus dorsi myocutaneous flap in combination with a prosthesis is widely used, well-established procedure. Short- and medium-term evaluation after this procedure well described the literature, but there have been no evaluations of late course (over 10 years) published until now.In retrospective study, 68 patients operated on means technique at authors' institution from 1981 to 1993 resulting minimal follow-up years were included. Patients invited an...
Summary There are few treatment options for patients with Hodgkin Lymphoma (HL) who relapse after conventional therapies. Panobinostat is an orally available pan deacetylase inhibitor evidence of activity in myeloid malignancies and cutaneous T cell lymphoma. Thirteen HL were treated escalating doses this novel agent a phase IA/II multicentre study. A computed tomography partial response was achieved 5/13(38%), metabolic by 18 F‐fluoro‐2‐deoxy‐ d ‐ glucose positron emission scanning 7/12...
Background The CXCR4 chemokine receptor regulates migration and homing of cancer cells to specific metastatic sites. Determination the status will provide predictive information for disease prognosis possible therapeutic intervention. However, previous attempts localize using poorly characterized mouse monoclonal or rabbit polyclonal antibodies have produced predominant nuclear occasional cytoplasmic staining but did not result in identification bona fide cell surface receptors....
Lung cancer is the most common worldwide and leading cause of cancer-related deaths in both men women. Despite development novel therapeutic interventions, 5-year survival rate for non-small cell lung (NSCLC) patients remains low, demonstrating necessity treatments. One strategy to improve translational research surrogate models reflecting somatic mutations identified as these impact treatment responses. With advent CRISPR-mediated genome editing, gene deletion well site-directed integration...
The emphasis on aesthetic outcomes and quality of life (QoL) has motivated surgeons to develop skin-sparing or nipple-sparing mastectomy (SSM/ NSM) for breast cancer treatment prevention. During the same operation, a so-called immediate reconstruction is performed. can be reconstructed by positioning implant above (prepectoral) below (subpectoral) pectoralis major muscle using patients' own tissue (autologous reconstruction). optimal prepectoral subpectoral currently not clear. Subpectoral...
Abstract Squamous cell carcinomas (SCC) frequently have an exceptionally high mutational burden. As consequence, they rapidly develop resistance to platinum-based chemotherapy and overall survival is limited. Novel therapeutic strategies are therefore urgently required. SCC express ∆Np63, which regulates the Fanconi Anemia (FA) DNA-damage response in cancer cells, thereby contributing chemotherapy-resistance. Here we report that deubiquitylase USP28 recruited sites of DNA damage...
Despite advances in treatment of patients with non-small cell lung cancer, carriers certain genetic alterations are prone to failure. One such factor frequently mutated, is the tumor suppressor PTEN. These tumors supposed be more resistant radiation, chemo- and immunotherapy.We demonstrate that loss PTEN led altered expression transcriptional programs which directly regulate therapy resistance, resulting establishment radiation resistance. While PTEN-deficient cells were not dependent on...
Abstract Background Neutrophils play a crucial role in inflammation and the increased thrombotic risk myeloproliferative neoplasms (MPNs). We have investigated how neutrophil-specific expression of JAK2-V617F or CALRdel re-programs functions neutrophils. Methods Ly6G-Cre mice were generated. MPN parameters as blood counts, splenomegaly bone marrow histology compared to wild-type mice. Megakaryocyte differentiation was using lineage-negative cells upon vitro incubation with TPO/IL-1β....
BRAWO, a real-world study, assessed the efficacy, quality of life (QoL) and safety EVE + EXE in postmenopausal women with HR+/HER2- advanced breast cancer (ABC) routine clinical practice. Postmenopausal HR+/HER2-ABC recurrence or progression after NSAI were included. Primary Observation parameters included evaluation effectiveness EXE. A multivariate-analysis using Cox proportional hazard model was built to identify predictors progression. Overall, 2100 patients enrolled (August...
For decades, BNCT was seen as an attractive concept and intellectual challenge with no prospect of widespread clinical application. This situation has changed fundamentally in just a few years the progress accelerator technology. Low-energy, high-intensity neutron sources can now be integrated into hospitals are therefore directly available for patient treatment. A pioneer this field is development Japan, where patients already being treated three hospitals, using in-house accelerator-based...