A5101742337- Chronic Myeloid Leukemia Treatments
- Nuclear Physics and Applications
- Chronic Lymphocytic Leukemia Research
- Nuclear reactor physics and engineering
- Radiation Detection and Scintillator Technologies
- High-pressure geophysics and materials
- Eosinophilic Disorders and Syndromes
- Advanced X-ray Imaging Techniques
- Fungal Biology and Applications
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Click Chemistry and Applications
- Toxic Organic Pollutants Impact
- Agricultural Practices and Plant Genetics
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Effects and risks of endocrine disrupting chemicals
- Mycorrhizal Fungi and Plant Interactions
- Fibroblast Growth Factor Research
- Multiple Myeloma Research and Treatments
- Food composition and properties
- Enzyme Production and Characterization
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
Bristol-Myers Squibb (United States)
2022-2024
Vivekananda Parvatiya Krishi Anusandhan Sansthan
2016-2023
Dr. Shakuntala Misra National Rehabilitation University
2022-2023
Mewar University
2022
University of Lucknow
2022
Novartis (United States)
2015-2020
Govind Ballabh Pant University of Agriculture and Technology
2008-2020
Tris Pharma (United States)
2015
Novartis (Switzerland)
2013-2014
Nobel Academy
2014
Despite advancements, prognosis for patients with relapsed/refractory multiple myeloma (MM) is poor, and novel therapies are needed. Panobinostat a potent deacetylase inhibitor that elicits synergistic effects on MM cells in combination bortezomib. This phase Ib study sought to determine the maximum-tolerated dose (MTD) of panobinostat plus bortezomib relapsed or refractory MM.In dose-escalation (n = 47), was administered orally thrice weekly every week (21-day cycles). After MTD...
Objectives: In oncology drug development, the overall response rate (ORR) is commonly used as an early endpoint to assess clinical benefit of a new intervention. ORR benefits, however, may not always translate well into long-term such survival (OS) [1-2]. recent decades, exploring different metrics capturing tumor growth dynamics (TGD) has been interest developers and regulatory agencies alternative make trial decisions [3-5]. However, there systematic evaluation TGD endpoints, resulting in...
2502 Background: Induction of PD-L1 expression due to constitutive oncogenic signaling has been reported in NSCLC models harboring EML4–ALK rearrangements. Here we explore whether the combination ALKi (ceritinib) and PD1-inhibitor (NIVO) will provide sustained clinical benefit pts with ALK+ NSCLC. Methods: This phase 1 dose escalation study enrolled previously treated (ALK inhibitor [ALKi] or chemotherapy) tx-naive stage IIIB/IV NSCLC; who received NIVO 3 mg/kg IV Q2W + ceritinib low-fat...
Tyrosine kinase inhibitor therapy revolutionized chronic myeloid leukemia treatment and showed how targeted molecular monitoring could be used to substantially improve survival outcomes. We as a model understand critical question: why do some patients have an excellent response therapy, while others poor response? studied gene expression in whole blood samples from 112 large phase III randomized trial (clinicaltrials gov. Identifier: NCT00471497), dichotomizing cases into good responders...
A thermal neutron imaging facility has been set up at the North Carolina State University PULSTAR reactor. The is an open pool light water moderated 1 MWth research reactor with six beam tubes. present on tube # 5 of intended to have radiographic and tomographic capabilities. design collimator was performed using MCNP5. includes a 4-in bismuth filter followed by 6-in single-crystal sapphire filter. Thermal scattering cross-section libraries for were generated used in MCNP simulation system....
Background: Asciminib is a potent and specific inhibitor of BCR‐ABL1. Unlike BCR‐ABL1 TKIs that target the ATP binding site, asciminib binds to myristoyl pocket ABL1. The combination with ATP‐competitive showed cooperativity in preclinical studies may provide more inhibition prevent emergence resistance mutations. In an ongoing phase 1 study (NCT02081378), monotherapy demonstrated clinical activity good safety/tolerability CML pts, including those T315I mutation; for chronic (CP) pts without...
Multi drug resistance microorganism is considered to be one of the major health problems. The aim this study was determine antibiotic susceptibility pattern bacterial pathogens surgical site infection. A total 250 samples were included, out which 62.4% showed significant growth. Gram negative bacteria 85.25% and gram positive 14.75%; among them 65.38% isolates multi (MDR). age group between 31 - 40 found highest number 22.4%. Among bacilli, production MDR in Acinetobacter spp. followed by...
Background: Asciminib is a potent and specific inhibitor of BCR-ABL1. Unlike BCR-ABL1 TKIs that target the ATP binding site, asciminib binds to myristoyl pocket ABL1. The combination with ATP-competitive showed cooperativity in preclinical studies may provide more inhibition prevent emergence resistance mutations. In an ongoing phase 1 study (NCT02081378), monotherapy demonstrated clinical activity good safety/tolerability CML pts, including those T315I mutation; for chronic (CP) pts without...
The Greenhouse whitefly (GWF), Trialeurodes vaporariorum (Westwood) (Hemiptera: Aleyrodidae), is a destructive pest that affects protected cultivation worldwide. Indian Himalayan region particularly vulnerable to GWF introduction, invasion, and spread due the expansion of climate change. In this study, we collected 32 naturally occurring populations, mainly from Uttarakhand state in region, investigate distribution pattern genetic diversity T. vaporariorum. Our sampling was representative...
Two year old guava trees cv.Pant Prabhat were sprayed with zinc sulphate (0, 0.2, 0.4 and 0.6 %) First spray was applied in June second September only on fifty per cent of the trees.The number foliar sprays various concentrations did not affect tree height, canopy, trunk diameter volume.However, maximum increase shoot length observed sulphate.The minimum flower fruit drop fruits tree, weight yield ha double (0.6 %).The leaf N (1.091 Zn (139.29 ppm) contents found while, K (0.434 phosphorus...
Background: The control of the Covid-19 epidemic depends on designing a novel, effec-tive vaccine against it. Currently, available vaccines cannot provide complete protection various mutants Covid-19. Objective: present investigation aimed to design new multi-epitope by using in silico tools. Methods: In study, spike-glycoprotein was targeted, desirably stimulating both B and T-cell lymphocytes, providing effective safe responses host immune system. de-sired has been found possess 448 amino...
One of the factors now beginning to seriously limit clock rates in large synchronous designs is manufacturing variations device parameters. Moreover, such random process are increasing significantly with scaling as technology approaches end silicon roadmap. In a design containing several millions transistors, virtually every manufactured part will have few hundreds transistors that significant performance outliers. Any one critical path can greatly highest rate be achieved by chip. this...
A neutron imaging facility is located on beam-tube #5 of the 1-MWth PULSTAR reactor at North Carolina State University. An investigation has been initiated to explore application coded techniques facility. Coded uses a mosaic pinholes encode an aperture, thus generating encoded image object detector. To reconstruct recorded by detector, corresponding decoding patterns are used. The optimized design masks critical for performance this technique and will depend characteristics beam. In work,...