A5002266644- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Infection Control and Ventilation
- Health and Medical Studies
- Disaster Response and Management
- COVID-19 epidemiological studies
- Iron Metabolism and Disorders
- Influenza Virus Research Studies
- Infection Control in Healthcare
- Zoonotic diseases and public health
- Bacillus and Francisella bacterial research
- SARS-CoV-2 detection and testing
- Vaccine Coverage and Hesitancy
- Travel-related health issues
- Medical and Health Sciences Research
- Viral Infections and Vectors
- Hemoglobinopathies and Related Disorders
- Tuberculosis Research and Epidemiology
- COVID-19 and Mental Health
- Viral gastroenteritis research and epidemiology
- Immunodeficiency and Autoimmune Disorders
- Trace Elements in Health
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Clinical Research Studies
Goethe University Frankfurt
2008-2022
Gesundheitsamt
2007-2022
University Hospital Frankfurt
2017-2022
Robert Koch Institute
2019
Institut de Recherche pour le Développement
2018
Méditerranée Infection Foundation
2018
Aix-Marseille Université
2018
DAK-Gesundheit (Germany)
2011-2012
Center for Prevention and Treatment of Infections
2012
Gesundheitsnetz Rhein-Neckar
2011
Coronavirus in Travelers Returning from China A group of 126 German nationals was evacuated Wuhan to Frankfurt after screening for symptoms Covid-19 and undergo a 14-day quarantine a...
Summary In recent studies, sputum smear cell counts were found to be reproducible and usefully applied research in asthma other airway conditions. However, definition on the smears is poor, procedure tedious has limited utility. The objective of this study improve methods examination. subjects used people with bronchitis or from whom could obtained. By inverted microscopy, portions fresh selected exclude salivary contamination. These exposed different volumes dithiothreitol for varied lime...
The capacity of convalescent and vaccine-elicited sera monoclonal antibodies (mAb) to neutralize SARS-CoV-2 variants is currently high relevance assess the protection against infections. We performed a cell culture-based neutralization assay focusing on authentic B.1.617.1 (Kappa), B.1.617.2 (Delta), B.1.427/B.1.429 (Epsilon), all harboring spike substitution L452R. found that L452R had reduced susceptibility mAbs. Compared B.1, Kappa Delta showed by factor 8.00 5.33, respectively, which...
Abstract Whether monoclonal antibodies are able to neutralize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern has been investigated using pseudoviruses. In this study we show that bamlanivimab, casirivimab, and imdevimab efficiently authentic SARS-CoV-2, including variant B.1.1.7 (alpha), but B.1.351 (beta) P.2 (zeta) were resistant against bamlanivimab partially casirivimab. variantshas We SARS-CoV-2 carrying E484K less susceptible convalescent vaccine-elicited sera.
Summary A standard magnetic resonance imaging (MRI) system allowing spin echo times of 10 ms was used to quantitate liver iron concentration in nine healthy normal subjects and 13 patients with various grades overload. Body status estimated by measuring the serum ferritin concentration. In 11 (two controls, eight HLA‐related hereditary haemochromatosis one patient thalassaemia major) non‐haem hepatic determined chemically biopsy specimens (dry weight), parallel MRI‐T2 relaxation times....
Objective: To evaluate the interferon-γ-releasing assays QuantiFERON-tuberculosis (TB) Gold and T-SPOT.TB in addition to tuberculin skin test (TST) for diagnosis of latent tuberculosis infection HIV patients. Design, setting participants: Prospective cross-sectional study asymptomatic HIV-infected outpatients from a large University hospital. Intervention: Simultaneous performance QuantiFERON-TB Gold, TST. Main outcome measures: Incidence risk factors positive reaction concordance (κ)...
Abstract The IgG1 monoclonal antibody (mAb) bamlanivimab (LY-CoV555) prevents viral attachment and entry into human cells by blocking to the ACE2 receptor. However, whether is equally effective against SARS-CoV-2 emerging variants of concern (VOC) not fully known. Hence, aim this study was determine VOC. ability neutralize five including B.1.1.7 (mutations include N501Y del69/70), B.1.351 E484K N501Y) P.2 in absence a mutation) analyzed infectious cell culture using CaCo2 cells....
Background —Black tea is known to be a potent inhibitor of intestinal absorption non-haem iron at least in healthy subjects. Aims —To investigate this effect patients with genetic haemochromatosis, and, more importantly, the regular drinking on accumulation storage these over one year. Patients —Investigations were carried out 18 clinically proven haemochromatosis. For study accumulation, they separated into group instructed drink particularly tannin rich regularly meals and control group....
Hepatic and portal vein flow pattern in correlation with intrahepatic fat deposition liver histology patients chronic hepatitis C.C F Dietrich, J H Lee, R Gottschalk, G Herrmann, C Sarrazin, W Caspary S ZeuzemAudio Available | Share
Objectives: Our paper measures the prevalence of hepatitis B virus (HBV), C (HCV) and human immunodeficiency (HIV) in patients at University Hospital Frankfurt/Main, correlates with risk factors for exposure to infection healthcare workers (HCWs). Individual assessments were calculated exposed HCWs.
In a patient transferred from Togo to Cologne, Germany, Lassa fever was diagnosed 12 days post mortem. Sixty-two contacts in Cologne were categorised according the level of exposure, and gradual infection control measures applied. No clinical signs virus or specific antibodies observed 62 contacts. Thirty-three individuals had direct contact blood, other body fluids tissue patients. Notably, with standard precautions, no transmission occurred between index healthcare workers. However, one...
In Emergency and Medical Admission Departments (EDs MADs), prompt recognition appropriate infection control management of patients with Highly Infectious Diseases (HIDs, e.g. Viral Hemorrhagic Fevers SARS) are fundamental for avoiding nosocomial outbreaks.
Abstract The capacity of convalescent and vaccine-elicited sera monoclonal antibodies (mAb) to neutralize SARS-CoV-2 variants is currently high relevance assess the protection against infections. We performed a cell culture-based neutralization assay focusing on authentic B.1.617.1 (Kappa), B.1.617.2 (Delta), B.1.427/B.1.429 (Epsilon), all harboring spike substitution L452R. found that L452R had reduced susceptibility mAbs. Compared B.1, Kappa Delta showed by factor 8.00 5.33, respectively,...
Abstract: Genetic hemochromatosis (GH) is closely associated with genes of the major histocompatibility complex (MHC) on chromosome 6. Recently, a candidate gene for GH, structural similarities to MHC class I genes, designated HLA‐H and presently named HFE, has been cloned. The HFE localized telomeric several reports have indicated that mutated in GH patients. In present study we analyzed relationship variants disease manifestation patients family members. Fifty‐seven 73 members 153 healthy...
The emergence of the influenza A(H1N1)2009 virus provided a major challenge to health services around world. However, vaccination rates for public and healthcare workers (HCWs) have remained low. We performed study review reasons put forward by HCWs refuse immunisation with pandemic vaccine in 2009/10 characterise attitudes season 2010/11 due A(H1N1)2009. A survey among medical students clinical phase their studies was conducted, using an anonymous questionnaire, at German university...
Background Highly Infectious Diseases (HIDs) are (i) easily transmissible form person to person; (ii) cause a life-threatening illness with no or few treatment options; and (iii) pose threat for both personnel the public. Hence, even suspected HID cases should be managed in specialised facilities minimizing infection risks but allowing state-of-the-art critical care. Consensus statements on operational management of isolation have been published recently. The study presented was set up...