A5047553183- Viral Infections and Outbreaks Research
- Malaria Research and Control
- Disaster Response and Management
- Influenza Virus Research Studies
- Travel-related health issues
- Respiratory viral infections research
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Viral Infections and Vectors
- Bacillus and Francisella bacterial research
- Emergency and Acute Care Studies
- Mosquito-borne diseases and control
- Tuberculosis Research and Epidemiology
- Education Systems and Policy
- Hepatitis Viruses Studies and Epidemiology
- Herpesvirus Infections and Treatments
- Bacterial Infections and Vaccines
- Food Allergy and Anaphylaxis Research
- Infection Control and Ventilation
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hematological disorders and diagnostics
- Zoonotic diseases and public health
- Infection Control in Healthcare
- Nematode management and characterization studies
Los Angeles Medical Center
2024
Institut de Recherche pour le Développement
2018
Méditerranée Infection Foundation
2018
Aix-Marseille Université
2018
The Royal Free Hospital
2000-2015
University College London
2000-2015
Royal Free London NHS Foundation Trust
2004-2014
Center for Prevention and Treatment of Infections
2012
Goethe University Frankfurt
2012
National Health Service
2011
<h3>Background</h3> Although generally mild, the 2009–2010 influenza A/H1N1 pandemic caused two major surges in hospital admissions UK. The characteristics of patients admitted during successive waves are described. <h3>Methods</h3> Data were systematically obtained on 1520 to 75 UK hospitals between May 2009 and January 2010. Multivariable analyses identified factors predictive severe outcome. <h3>Results</h3> Patients aged 5–54 years over-represented compared with winter seasonal for acute...
Abstract To determine clinical characteristics of patients hospitalized in the United Kingdom with pandemic (H1N1) 2009, we studied 1,520 75 National Health Service hospitals. We characterized who acquired influenza nosocomially during 2009 outbreak. Of 30 patients, 12 (80%) 15 adults and 14 (93%) children had serious underlying illnesses. Only (57%) 21 received antiviral therapy did so within 48 hours after symptom onset, but 53% needed escalated care or mechanical ventilation; 8 (27%)...
Background Statins are drugs that used to lower plasma cholesterol levels. Recently, contradictory claims have been made about possible additional effects of statins on progression a variety inflammatory disorders, including infections. We therefore examined the clinical course patients admitted hospital with 2009 pandemic influenza A(H1N1), who were or weren't taking at time admission. Methods A retrospective case-control study was performed using United Kingdom Influenza Clinical...
Asthmatics hospitalised because of influenza A infection are less likely to require intensive care or die compared with nonasthmatics. The reasons for this unknown. We performed a retrospective analysis data on 1520 patients admitted 75 UK hospitals confirmed A/H1N1 2009 infection. multivariable model was used investigate the association between asthma and severe outcomes (intensive unit support death). were than nonasthmatics have outcome (11.2% versus 19.8%, unadjusted OR 0.51, 95% CI...
<h3>Background</h3> Early identification of patients with H1N1 influenza-related pneumonia is desirable for the early instigation antiviral agents. A study was undertaken to investigate whether adults admitted hospital could be distinguished clinically from non-H1N1 community-acquired (CAP). <h3>Methods</h3> Between May 2009 and January 2010, clinical epidemiological data confirmed influenza infection 75 hospitals in UK were collected by Influenza Clinical Information Network (FLU-CIN)....
Because tuberculosis (TB) is primarily a pulmonary disease, we examined the cytokine responses of CD4(+) T lymphocytes in bronchoalveolar lavage (BAL) fluid after incubation with purified protein derivative (PPD) human immunodeficiency virus-negative patients TB and control subjects nontuberculous respiratory disease. Parallel blood BAL samples from each subject were incubated or without PPD, proportions producing interferon (IFN)-gamma tumor necrosis factor (TNF)-alpha measured by flow...
Five days after arriving in London from Jos a young Nigerian women developed severe and prolonged illness that proved to be Lassa fever. Virus was not detected urine during the first three weeks but then appeared reached peak sixth week, with continuing excretion for 67 onset of illness. Laboratory investigations showed evidence extensive tissue damage disturbance clotting, there no serious bleeding she eventually made complete recovery despite high sustained viraemia liver damage....
In Emergency and Medical Admission Departments (EDs MADs), prompt recognition appropriate infection control management of patients with Highly Infectious Diseases (HIDs, e.g. Viral Hemorrhagic Fevers SARS) are fundamental for avoiding nosocomial outbreaks.
The aetiology of acute viral hepatitis in 172 patients admitted to an infectious diseases hospital North London was: A 88 (51%), B 58 (34%), Epstein-Barr (EB) virus four (2%) and non-A, non-B 22 (13%). NANB was a milder disease than that associated with the other viruses. It predominantly occurred young men (77%). In half cases there evidence parenteral transmission. not transmitted by sexual contact.
Background Highly Infectious Diseases (HIDs) are (i) easily transmissible form person to person; (ii) cause a life-threatening illness with no or few treatment options; and (iii) pose threat for both personnel the public. Hence, even suspected HID cases should be managed in specialised facilities minimizing infection risks but allowing state-of-the-art critical care. Consensus statements on operational management of isolation have been published recently. The study presented was set up...
Isolation of patients with highly infectious diseases (HIDs) in hospital rooms adequate technical facilities is essential to reduce the risk spreading disease. The European Network for Infectious Diseases (EUNID), a project co-funded by Commission and involving 16 Union member states, performed an inventory high level isolation (HIRs, negative pressure anteroom). In participating countries, HIRs are available at least 211 hospitals, 1789 beds. adequacy this number not known will depend on...
BackgroundThe management of patients with highly infectious diseases (HIDs) is a challenge for healthcare provision requiring high level care without compromising the safety other and workers.AimTo study infection control practice in isolation facilities participating European Network Highly Infectious Diseases (EuroNHID) project.MethodsA survey was conducted during 2009 48 caring HIDs 16 countries. Checklists standard evaluation forms were used to collect interpret data on hand hygiene,...
Objective. To collect data about personal protective equipment (PPE) management and to provide indications for improving PPE policies in Europe. Design. Descriptive, cross-sectional survey. Setting Participants. Data were collected 48 isolation facilities 16 European countries nominated by National Health Authorities the of highly infectious diseases (HIDs). Methods. through standardized checklists at on-site visits during February-November 2009. Indications adequate developed on basis a...
Introduction The Influenza Clinical Information Network (FLU-CIN) was established to gather detailed clinical and epidemiological information about patients with laboratory confirmed A(H1N1)pdm09 infection in UK hospitals. This report focuses on the course outcomes of pregnancy. Methods A standardised data extraction form used obtain from hospital case notes electronic records, for PCR-confirmed admitted 13 sentinel hospitals five 'hubs' a further 62 non-sentinel hospitals, between 11th May...