A5047130710- Clostridium difficile and Clostridium perfringens research
- Microscopic Colitis
- Viral gastroenteritis research and epidemiology
- Nosocomial Infections in ICU
- Helicobacter pylori-related gastroenterology studies
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Gut microbiota and health
- Bacterial Identification and Susceptibility Testing
- Hereditary Neurological Disorders
- Pharmaceutical and Antibiotic Environmental Impacts
- Gastrointestinal motility and disorders
- Neurological diseases and metabolism
- Enterobacteriaceae and Cronobacter Research
- Herbal Medicine Research Studies
- Antibiotic Use and Resistance
- Bacterial biofilms and quorum sensing
- Veterinary medicine and infectious diseases
- Vestibular and auditory disorders
- Streptococcal Infections and Treatments
- Caveolin-1 and cellular processes
- Genetics and Neurodevelopmental Disorders
- Genetic Neurodegenerative Diseases
- Hearing, Cochlea, Tinnitus, Genetics
- Chemical Reactions and Isotopes
Charles University
2016-2025
European Society of Clinical Microbiology and Infectious Diseases
2017-2024
University Hospital in Motol
2014-2024
University of Macerata
2023
Brunel University of London
2023
Lagos State Health Service Commission
2023
Ekiti State University
2023
Ospedale di Macerata
2023
Network Group (Czechia)
2023
In 2009, the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) published first treatment guidance document for Clostridioides difficile infection (CDI). This was updated in 2014. The growing literature on CDI antimicrobial novel approaches, such as faecal microbiota transplantation (FMT) toxin-binding monoclonal antibodies, prompted ESCMID study group C. (ESGCD) to update 2014 adults.Key questions were formulated by guideline committee included: What is best initial,...
Introduction Hospitals and wastewater are recognized hot spots for the selection dissemination of antibiotic-resistant bacteria to environment, but total participation hospitals in spread nosocomial pathogens municipal treatment plants (WWTPs) adjacent rivers had not previously been revealed. Methods We used a combination culturing whole-genome sequencing explore transmission routes Escherichia coli from hospitalized patients suffering urinary tract infections (UTI) via environment. Samples...
Inherited peripheral neuropathies (IPN) are the most common inherited neurological condition. It represents a highly heterogeneous group, both clinically and genetically. Targeted disease specific gene panel massively parallel sequencing (MPS) seems to be useful tool in diagnosis of disorders with high genetic heterogeneity. In our study, we have designed, validated updated own custom all known genes associated IPN. One hundred ninety-eight patients been tested so far. Only whom mutations...
We aimed to describe the clinical presentation, treatment, outcome and report on factors associated with mortality over a 90-day period in Clostridioides difficile infection (CDI). Descriptive, univariate, multivariate regression analyses were performed data collected retrospective case-control study conducted nine hospitals from seven European countries. A total of 624 patients included, which 415 deceased (cases) 209 still alive 90 days after CDI diagnosis (controls). The most common...
Public transport represents a potential site for the transmission of resistant pathogens due to rapid movement large numbers people. This study aimed investigate bacterial contamination frequently touched surfaces in public system operating proximity biggest Czech hospital during coronavirus pandemic despite extensive cleaning and disinfection efforts. In June September 2020, samples from metro trains, ground stationary objects were collected, enriched cultured. The antimicrobial...
We aimed to evaluate the efficacy of different antibiotic regimens for treatment Clostridioides difficile infection (CDI) with regard CDI episode number and disease severity.An observation cohort study included 271 patients hospitalised between 2013-2016. Univariate logistic regression was used association patients' clinical outcome (sustained cure or recurrence) in a 60-day follow-up regimen (oral metronidazole, oral vancomycin, combination vancomycin fidaxomicin). Subgroup analyses, based...
Pontocerebellar hypoplasia type 1 (PCH1) is characterized by cerebellar and anterior horn motor neuron degeneration loss, signs of spinal muscular atrophy plus. Patients manifest severe perinatal weakness, hypotonia, respiratory insufficiency, causing death frequently before the age year. Recently, causative mutations in EXOSC3 were reported a majority PCH1 patients, but detailed clinical phenotype caused mutations, genotype-phenotype correlations, prevalent specific ethnic groups not yet...
Clostridioides difficile infection (CDI) remains a major healthcare problem worldwide, however, little is known about CDI epidemiology in Iran. Between December 2004 and November 2018, 3649 stool samples were collected from patients 69 hospitals medical centres Tehran cultured for the presence of C. difficile; isolates characterized by PCR ribotyping toxin genes detection. A total 582 obtained overall prevalence was 15.9%; 290 (49.8%) cases healthcare-associated (HA) 292 (50.2%)...
Clostridioides difficile is one of the most important human pathogens. The identification its possible sources for understanding C. infection (CDI) epidemiology. A total 16 water samples from wastewater and surface in South Moravia Czech Republic 82 fish gulls were collected between May July 2019. isolates cultured by direct plating after enrichment on chromogenic media. Susceptibility testing to eight antimicrobials was performed Etest. characterized ribotyping, multilocus sequence typing,...
In 2014, 18 hospitals in the Czech Republic participated a survey of incidence Clostridium difficile infections (CDI) country. The mean CDI was 6.1 (standard deviation (SD):7.2) cases per 10,000 patient bed-days and 37.8 (SD: 41.4) admissions. testing frequency 39.5 tests 25.4) 255.8 164.0) A total 774 C. isolates were investigated, which 225 (29%) belonged to PCR ribotype 176, 184 (24%) 001. Multilocus variable-number tandem repeat analysis (MLVA) revealed 27 clonal complexes formed by 84%...