A5036263492- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Cancer Treatment and Pharmacology
- CAR-T cell therapy research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Monoclonal and Polyclonal Antibodies Research
- Clostridium difficile and Clostridium perfringens research
- Chronic Myeloid Leukemia Treatments
- Helicobacter pylori-related gastroenterology studies
- Parathyroid Disorders and Treatments
- Gut microbiota and health
- Systemic Lupus Erythematosus Research
- Inflammatory mediators and NSAID effects
- Acute Myocardial Infarction Research
- Ubiquitin and proteasome pathways
- Cancer therapeutics and mechanisms
- Cutaneous lymphoproliferative disorders research
- Acute Ischemic Stroke Management
- Microscopic Colitis
- Dermatological and Skeletal Disorders
- Lymphoma Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- T-cell and Retrovirus Studies
University Hospital Leipzig
2023-2024
Mayo Clinic
2021-2023
Leipzig University
2023
WinnMed
2022
Mayo Clinic in Arizona
2022
Jagiellonian University
2018-2021
Szpital Uniwersytecki w Krakowie
2019
John Paul II Hospital
2019
We aimed to describe the clinical presentation, treatment, outcome and report on factors associated with mortality over a 90-day period in Clostridioides difficile infection (CDI). Descriptive, univariate, multivariate regression analyses were performed data collected retrospective case-control study conducted nine hospitals from seven European countries. A total of 624 patients included, which 415 deceased (cases) 209 still alive 90 days after CDI diagnosis (controls). The most common...
The t(14;16) translocation, found in 3%-5% of newly diagnosed (ND) multiple myeloma (MM), has been associated with adverse outcomes. However, the studies establishing characteristics included solely small cohorts. goal current international, multicenter (n = 25 centers), retrospective study was to describe and outcomes patients a large, real-world cohort 223). A substantial fraction had renal impairment (24%) hemoglobin <10 g/dL (56%) on initial presentation. Combined therapy both...
Almost all patients with multiple myeloma (MM) eventually relapse, either asymptomatically or end-organ damage. However, it remains unclear whether initiating therapy at the time of biochemical progression (BP) improves outcomes compared clinical (CP) stage. Here, we retrospectively assessed 1347 relapsed MM. Most progressions were BP (60.4%); 39.6% had CP. The most prevalent symptoms relapse new evolving bone disease (80.9%), anemia (38.0%), and renal failure (12.7%). Patients longer median...
It is unclear whether thrombus location in pulmonary arteries associated with particular clot characteristics. We assessed 156 patients following either central or peripheral embolism (PE). Plasma lysis time, the rate of D-dimer release from plasma clots (D-Drate) maximum concentration achieved (D-Dmax), as well fibrin formation on turbidimetry, permeation, thrombin generation, and fibrinolytic parameters were measured 3-6 months after PE. Patients PE (n = 108, 69.3%) more likely smokers...
Multiple myeloma (MM) is an incurable haematological malignancy affecting approximately 7:100,000 people. Monoclonal gammopathy of undetermined significance (MGUS) and 'smouldering' MM precede symptomatic MM. Cytogenetics in the most powerful prognostication tool incorporated into different classifications, including Revised International Staging System (R-ISS) Mayo Clinic Risk Stratification for Myeloma (mSMART). Methods commonly used to test cytogenetic aberrations include conventional...
The treatment landscape for relapsed multiple myeloma (MM) has increased. In this study, we aimed to characterize 2nd (n = 1439) and 3rd 1104) line regimens compare the results between subgroups based on year of initiation (2nd line: 2003-2008, 2009-2015, 2016-2021; 2004-2009, 2010-2015, 2016-2021). both second- third- lines, observed increasing use novel agents (from 78 95% from 77 95%, respectively) triplet 15 69% 21 71%, respectively). most frequently used in last studied periods included...
Subcutaneous panniculitis-like T-cell lymphoma (SPTL) is a rare, cutaneous involving subcutaneous adipose tissue. SPTL associated in less than 20% with hemophagocytic syndrome (HPS). A 5-year overall survival rate inferior patients and HPS (46%) as compared 91% without HPS. No standardized therapy for SPTCL has yet been established. This case of 35-year-old Caucasian man one-month history B symptoms the suspicion Still's disease, at admission leucopenia, high LDH, ferritin, sIl-R2,...
The MAF translocations, t(14;16) and t(14;20), are considered as adverse prognostic factors based on few studies with small sample sizes. We report their impact in a large group of 254 patients – 223 (87.8%) 31 (12.2%) t(14;20). There were no intergroup differences survival estimates. Median progression-free was 16.6 months for 24.9 t(14;20) (p = 0.28). overall (OS) 54.0 49.0 months, respectively 0.62). OS who underwent double autologous stem cell transplantation (ASCT) 107.0 versus 60.0...
Amyloidosis is a heterogeneous group of protein misfolding diseases caused by extracellular deposition abnormal beta-fibrils resistant to proteolysis. The most common type light-chain amyloidosis (AL amyloidosis) which can be systemic or localized. Localized mostly affects the respiratory airways, genitourinary tract, gastrointestinal system skin. We present diagnostic and therapeutic approach in 25-year-old female patient diagnosed with urinary bladder amyloidosis. main complaint was...
Abstract The treatment landscape for relapsed multiple myeloma (MM) has increased. In this study we aimed to characterize 2nd (n = 1439) and 3rd 1104) line regimens compare the results between subgroups based on year of initiation (2nd line: 2003–2008, 2009–2015, 2016–2021; 2004–2009, 2010–2015, 2016–2021). both observed increasing use novel agents (from 78–95% from 77–95%, respectively) triplet 15–69% 21–71%, respectively). Most frequently used in last studied periods included...