A5046791261- Multiple Myeloma Research and Treatments
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Peptidase Inhibition and Analysis
- Bone health and treatments
- Protein Degradation and Inhibitors
- Renal Transplantation Outcomes and Treatments
- Cancer Genomics and Diagnostics
Heinrich Heine University Düsseldorf
2020-2025
Düsseldorf University Hospital
2022-2025
Abstract The hallmark of multiple myeloma (MM) is a clonal plasma cell infiltration in the bone marrow accompanied by myelosuppression and osteolysis. Premalignant stages such as monoclonal gammopathy undetermined significance (MGUS) asymptomatic smoldering (SMM) can progress to MM. Mesenchymal stromal cells (MSCs) are an integral component microenvironment play important role osteoblast differentiation hematopoietic support. Although alterations have been reported MM contributing...
Abstract Bispecific T‐cell engagers (BTCEs) represent a paradigm shift in the treatment of relapsed/refractory multiple myeloma (RRMM). Talquetamab, GPRC5DxCD3 BTCE, has shown promising results MonumenTAL‐1 trial and was recently approved by Food Drug Administration European Medicines Agency. However, under real‐world conditions may not patient characteristics clinical trials with restricted enrollment criteria. We performed retrospective analysis including 138 RRMM patients treated...
To evaluate the feasibility of in-vivo quantitative susceptibility mapping (QSM) human kidney.An axial single-breath-hold 3D multi-echo sequence (acquisition time 33 s) was completed on a 3 T-MRI-scanner (Magnetom Prisma, Siemens Healthineers, Erlangen, Germany) in 19 healthy volunteers. Graph-cut-based unwrapping combined with T2*-IDEAL approach performed to remove chemical shift fat and quantify QSM upper abdomen. Mean values entire, renal cortex medulla both kidneys liver were determined...
Randomized controlled trials (RCT) are the driver of therapeutic innovations. However, it has been frequently shown that less than 5% adult cancer patients enroll in clinical trials, although 70% considered as being willing to participate. Barriers trial participation have extensively studied. Although there is evidence correlates with improved survival and reduced mortality, rate not changed substantially. We provide retrospective data from a single-center analysis 411 multiple myeloma (MM)...
Abstract Purpose While 18 F-FDG PET/CT yields valuable prognostic information for patients in first-line therapy of multiple myeloma (MM), its relevance relapse is not established. Available studies relapsed MM describe thresholds frequently used parameters that are significantly higher than those identified the setting. The purpose this study was to evaluate role MM, based on Methods Our retrospective included 36 with who had received autologous or allogeneic stem cell transplantation,...
In DWI, multi-exponential signal analysis can be used to determine underlying diffusion components. However, the approach is very complex due inherent low SNR, limited number of decay data points, and absence appropriate acquisition parameters standardized methods. Within scope this work, different methods for in kidney were compared. To assess impact fitting parameters, a simulation was conducted comparing free non-negative (NNLS) rigid non-linear least square (NLLS) The demonstrated...